Match tier Listed
Presence Current · Arkansas
Last published 2025
Sources OpenAlex · ORCID
Refreshed 2026-08-20

J.A. Jamsen

Federal Grant PI

Assistant Professor

UAMS

Also affiliated: National Institutes of Health (2017–2022); City Of Hope National Medical Center (2012); University of Turku (2007–2012); National Institute of Environmental Health Sciences (2017–2022); City of Hope (2012); Beckman Research Institute (2012)

Faculty Researcher

10 h-index 32 pubs 346 cited

Research Areas

Biomedical Subjects

  • DNA Repair
  • DNA Breaks, Double-Stranded
  • Humans
  • Kinetics
  • Models, Molecular
  • Nucleotides
  • Protein Structure, Tertiary
  • DNA
  • DNA-Directed DNA Polymerase
  • Catalytic Domain
  • Animals
  • Adenosine Monophosphate
  • Bacterial Proteins
  • Protein Binding
  • Inorganic Pyrophosphatase

Links

ORCID Research Group

OverviewAI-generated summary

J.A. Jamsen's research focuses on the molecular mechanisms of DNA double-strand break repair, particularly the role of polymerases in this process. Jamsen investigates how these enzymes insert nucleotides and the fidelity checkpoints that govern their activity, with a specific interest in the insertion of oxidized nucleotides, which can be mutagenic. This work aims to understand the structural and kinetic aspects of polymerase function during DNA repair.

Funded by the National Institute of Environmental Health Sciences for $249,000, Jamsen is the Principal Investigator on a project examining the molecular architecture of oxidative stress-induced double-strand break repair. Jamsen leads a research group at the University of Arkansas for Medical Sciences and has a publication record including studies on Polλ's role in microhomology-mediated end-joining and the structural basis for nucleotide insertion during double-strand break repair. Jamsen's scholarship metrics include an h-index of 10, 32 total publications, and 343 total citations.

Metrics

  • h-index: 10
  • Publications: 32
  • Citations: 346

Selected Publications

  • Observing DNA Polymerase Double Strand Break Synthesis (2025)
    Structural Dynamics DOI OpenAlex
  • Author Correction: Polλ promotes microhomology-mediated end-joining (2023)
    Nature Structural & Molecular Biology DOI OpenAlex
  • Polλ promotes microhomology-mediated end-joining (2022)
    Nature Structural & Molecular Biology 29 citations DOI OpenAlex

View all publications on OpenAlex →

Federal Grants 2 $669,750 total

NIH Contact PI Aug 2026 - Mar 2031

Revealing DNA Polymerase Molecular Strategies in End-Joining Double Strand Break Repair

National Institute of General Medical Sciences $420,750 R35
NIH Contact PI Mar 2023 - Feb 2027

Molecular Architecture of Oxidative Stress Induced Double Strand Break Repair

National Institute of Environmental Health Sciences $249,000 R00

Collaboration Network

12 Collaborators 7 Institutions 2 Countries

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