A. Chalamalla
Researcher
Also affiliated: Arkansas Children's Hospital (2024–2026); Cystic Fibrosis Foundation (2024); University of Alabama at Birmingham (2024–2026)
Faculty Researcher
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
A. Chalamalla's research focuses on the pharmacokinetics of cystic fibrosis transmembrane conductance regulator (CFTR) modulators, particularly in adults with cystic fibrosis. Recent work investigates the variability in drug concentrations resulting from standard versus alternative treatment regimens, as well as the impact of concurrent medications like tacrolimus on modulator pharmacokinetics. Studies also explore the relationship between dietary composition and CFTR modulator concentrations, employing pilot and feasibility designs. A significant area of investigation involves using machine learning approaches for sparse sampling to predict average drug concentrations, evaluating the efficacy of single and multiple time points for this prediction. Collaborations include extensive work with Jennifer S. Guimbellot and Saly Abouelenein at the University of Arkansas for Medical Sciences.
Metrics
- h-index: 3
- Publications: 18
- Citations: 20
Selected Publications
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Assessing Dietary Patterns and Composition Among Adults With Cystic Fibrosis Taking Highly Effective Modulator Therapy (2026)
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One- and Two-timepoint Sparse Sampling is Highly Predictive of Average Plasma Concentration of CFTR Modulators (2025)
Collaboration Network
Top Collaborators
- One- and Two-timepoint Sparse Sampling is Highly Predictive of Average Plasma Concentration of CFTR Modulators
- One- and Two-timepoint Sparse Sampling is Highly Predictive of Average Plasma Concentration of CFTR Modulators
- One- and Two-timepoint Sparse Sampling is Highly Predictive of Average Plasma Concentration of CFTR Modulators
- One- and Two-timepoint Sparse Sampling is Highly Predictive of Average Plasma Concentration of CFTR Modulators
- Assessing Dietary Patterns and Composition Among Adults With Cystic Fibrosis Taking Highly Effective Modulator Therapy
- Assessing Dietary Patterns and Composition Among Adults With Cystic Fibrosis Taking Highly Effective Modulator Therapy
- Assessing Dietary Patterns and Composition Among Adults With Cystic Fibrosis Taking Highly Effective Modulator Therapy
- Assessing Dietary Patterns and Composition Among Adults With Cystic Fibrosis Taking Highly Effective Modulator Therapy
- Assessing Dietary Patterns and Composition Among Adults With Cystic Fibrosis Taking Highly Effective Modulator Therapy
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