Ann Varghese

Researcher

National Center for Toxicological Research

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2 h-index 4 pubs 15 cited

Research Areas

SARS-CoV-2 and COVID-19 Research Protein Structure and Dynamics Neuroscience and Neuropharmacology Research Advanced Neural Network Applications Computational Drug Discovery Methods Microbial infections and disease research Pharmacological Effects and Toxicity Studies

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OverviewAI-generated summary

Ann Varghese's research investigates the structural and molecular mechanisms underlying biological processes, with a recent focus on viral proteases and opioid receptors. Her work integrates computational methods such as molecular dynamics, molecular docking, and machine learning to predict enzyme binders, as demonstrated in her publications on SARS-CoV-2 papain-like protease. Varghese also studies the structural features of the kappa opioid receptor (KOR) and their implications for developing novel opioid analgesics. She has contributed to research on biomarkers for neurological conditions, including myotonic dystrophy type 1. Varghese collaborates with researchers at the National Center for Toxicological Research, including Tucker A. Patterson and Fan Dong. Her scholarly output includes 4 publications and has garnered 15 citations, with an h-index of 2.

Metrics

h-index: 2
Publications: 4
Citations: 15

Selected Publications

Integrating Molecular Dynamics, Molecular Docking, and Machine Learning for Predicting SARS-CoV-2 Papain-like Protease Binders (2025) DOI
Analysis of Structures of SARS-CoV-2 Papain-like Protease Bound with Ligands Unveils Structural Features for Inhibiting the Enzyme (2025) DOI
Decoding the κ Opioid Receptor (KOR): Advancements in Structural Understanding and Implications for Opioid Analgesic Development (2024) DOI