Erin Skeens Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Researcher

John Brown University

faculty

11 h-index 29 pubs 459 cited

Research Areas

CRISPR and Genetic Engineering Macrophage Migration Inhibitory Factor Advanced biosensing and bioanalysis techniques RNA and protein synthesis mechanisms Nuclear Receptors and Signaling

Links

ORCID

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OverviewAI-generated summary

Dr. Erin Skeens' research encompasses CRISPR-Cas9 systems, macrophage migration inhibitory factor (MIF), advanced biosensing techniques, and RNA/protein synthesis. Her work aims to elucidate the underlying mechanisms of genetic engineering and cellular signaling. Skeens' investigations into CRISPR-Cas9 have explored target DNA cleavage, the role of magnesium ions in catalysis, and the atomic-level communication within the Cas9 enzyme. She also employs topological data analysis to discover biophysical signatures in protein dynamics. Her studies on MIF have revealed redox-dependent structural dynamics and allosteric sites. Skeens' recent work focuses on understanding the conformational changes in Cas9 that facilitate DNA recognition, cleavage, and release.

Metrics

  • h-index: 11
  • Publications: 29
  • Citations: 459

Selected Publications

  • A Cryptic Binding Pocket Regulates the Metal-Dependent Activity of Cas9 (2025) DOI
  • Redox-dependent plasticity of oxMIF facilitates its interaction with CD74 and therapeutic antibodies (2024) DOI
  • Redox-Dependent Structure and Dynamics of Macrophage Migration Inhibitory Factor Reveal Sites of Latent Allostery (2021) DOI

Collaborators

Researchers in the database who share publications

George P. Lisi John Brown University 19 shared publications Brenda M. Rubenstein John Brown University 2 shared publications Alexandra M D'Ordine John Brown University 2 shared publications G. Jogl John Brown University 2 shared publications

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