Ryan Porter
Sourced from institutional research profiles (UAMS TRI or ARA).
Assistant Professor
Internal Med, College of Medicine
Research Areas
Biography and Research Information
OverviewAI-generated summary
Ryan Porter's research program focuses on chondrocyte biology and cartilage regenerative medicine, with the goal of developing improved strategies to protect articular cartilage from degeneration. Articular cartilage is essential for synovial joint function, and its loss is a characteristic of osteoarthritis (OA). His current projects investigate why chondrocytes, the sole cell type within cartilage, are unable to maintain tissue integrity during the onset of OA. A second theme of his work aims to enhance therapeutic drug delivery to articular cartilage to prevent tissue loss and stimulate repair.
This research has received support from federal agencies including the National Institutes of Health and the Department of Veterans Affairs, as well as from the Arkansas Biosciences Institute and the UAMS College of Medicine’s Bone and Joint Initiative. Porter serves as Principal Investigator on an NIH-funded project studying NAD homeostasis, articular cartilage loss, and osteoarthritis. He leads a research group within the Department of Internal Medicine at the University of Arkansas for Medical Sciences.
Research Overview
My research program focuses on chondrocyte biology and cartilage regenerative medicine. Articular cartilage is vital to the function of synovial joints, and its loss is a central feature of osteoarthritis (OA). A long term goal of this research is to develop better strategies to protect articular cartilage from degeneration in response to joint injury or aging, two major risk factors for developing OA. Current projects can be divided into two themes. The first seeks to understand why chondrocytes, the lone cells within cartilage, fail to maintain this tissue during the onset of OA. The second theme aims to improve therapeutic drug delivery to articular cartilage, in order to prevent tissue loss and/or stimulate repair. This work has been supported by the National Institutes of Health, the Department of Veterans Affairs, the Arkansas Biosciences Institute, and the UAMS College of Medicine’s Bone and Joint Initiative.
Federal Grants 1
NAD homeostasis, articular cartilage loss, and osteoarthritis
Research Interests
Articular Cartilage; Osteoarthritis; Mesenchymal Stromal Cells, Multipotent; Aging; Drug Delivery Systems; Regenerative Medicine; Gene Therapy
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Role of subchondral bone osteocytes in post-traumatic osteoarthritis US Department of Defense Co-Investigator
- Center for Musculoskeletal Disease Research (CMDR) NIH/Nat. Inst. of General Medical Sciences Co-Investigator
- Intra-cartilage depot delivery of electrically-charged IL-1RA for targeting osteoarthritis-associated inflammation and catabolism in multiple joint tissues NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases via Northeastern University Co-Investigator
- A Transgenic Rat for Noninvasive Assessment of Chondrogenic Activity in vivo NIH Principal Investigator
- Drug Delivery System for Treating Post Traumatic Osteoarthritis in Human and Equine Populations MIT Deshpande Center for Technological Innovation via Massachusetts Institute of Technology Co-Investigator
- Harnessing Extracellular Vesicles to Direct the Repair of Osseous Defects NIH Principal Investigator
Frequent Collaborators
Similar Researchers
Based on overlapping research topics