Zachary J. McKenna Data-verified
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Biography and Research Information
OverviewAI-generated summary
Zachary J. McKenna's research investigates the physiological responses to environmental stressors, particularly heat and altitude, and their interplay with exercise. His work examines how factors such as age and hydration status influence thermoregulation, intestinal barrier integrity, and the risk of acute kidney injury during physical exertion in hot conditions. McKenna also studies the effects of exercise on inflammatory markers, including Toll-like receptor-4, in leukocytes and skeletal muscle, and explores the potential role of exercise-induced muscle damage in exertional heat stroke. He has published 94 works, with an h-index of 14 and 556 total citations. He collaborates with Brendon P. McDermott at the University of Arkansas at Fayetteville.
Metrics
- h-index: 14
- Publications: 96
- Citations: 576
Selected Publications
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Biomarkers of organ stress and injury following the Boston Marathon (2025)
Collaboration Network
Top Collaborators
- Age alters the thermoregulatory responses to extreme heat exposure with accompanying activities of daily living
- Aging Increases Enterocyte Damage during a 3-Hour Exposure to Very Hot and Dry Heat: A Preliminary Study
- Human heat resilience in a warming climate: Biophysical and physiological underpinnings of heat vulnerability and personal cooling strategies
- Gastrointestinal permeability and kidney injury risk during hyperthermia in young and older adults
- Kidney Function Biomarkers During Extreme Heat Exposure in Young and Older Adults
Showing 5 of 25 shared publications
- Age alters the thermoregulatory responses to extreme heat exposure with accompanying activities of daily living
- Aging Increases Enterocyte Damage during a 3-Hour Exposure to Very Hot and Dry Heat: A Preliminary Study
- Human heat resilience in a warming climate: Biophysical and physiological underpinnings of heat vulnerability and personal cooling strategies
- Gastrointestinal permeability and kidney injury risk during hyperthermia in young and older adults
- Kidney Function Biomarkers During Extreme Heat Exposure in Young and Older Adults
Showing 5 of 23 shared publications
- Age alters the thermoregulatory responses to extreme heat exposure with accompanying activities of daily living
- Aging Increases Enterocyte Damage during a 3-Hour Exposure to Very Hot and Dry Heat: A Preliminary Study
- Gastrointestinal permeability and kidney injury risk during hyperthermia in young and older adults
- Kidney Function Biomarkers During Extreme Heat Exposure in Young and Older Adults
- Identifying the Optimal Heat Exposure Metric for Predicting the Physiological Response to Dry or Humid Heat Stress in Young and Older Adults: A Randomized Controlled Study
Showing 5 of 23 shared publications
- High-altitude exposures and intestinal barrier dysfunction
- Repeated sprint exercise in hypoxia stimulates HIF-1-dependent gene expression in skeletal muscle
- The effect of prolonged interval and continuous exercise in the heat on circulatory markers of intestinal barrier integrity
- The Potential Role of Exercise-Induced Muscle Damage in Exertional Heat Stroke
- Strategies to mitigate acute kidney injury risk during physical work in the heat
Showing 5 of 18 shared publications
- High-altitude exposures and intestinal barrier dysfunction
- Repeated sprint exercise in hypoxia stimulates HIF-1-dependent gene expression in skeletal muscle
- The effect of prolonged interval and continuous exercise in the heat on circulatory markers of intestinal barrier integrity
- The Potential Role of Exercise-Induced Muscle Damage in Exertional Heat Stroke
- Change in Exercise Performance and Markers of Acute Kidney Injury Following Heat Acclimation with Permissive Dehydration
Showing 5 of 17 shared publications
- Repeated sprint exercise in hypoxia stimulates HIF-1-dependent gene expression in skeletal muscle
- The effect of prolonged interval and continuous exercise in the heat on circulatory markers of intestinal barrier integrity
- Change in Exercise Performance and Markers of Acute Kidney Injury Following Heat Acclimation with Permissive Dehydration
- The combined effects of exercise-induced muscle damage and heat stress on acute kidney stress and heat strain during subsequent endurance exercise
- Stimulated myotube contractions regulate membrane-bound and soluble TLR4 to prevent LPS-induced signaling and myotube atrophy in skeletal muscle cells
Showing 5 of 14 shared publications
- Repeated sprint exercise in hypoxia stimulates HIF-1-dependent gene expression in skeletal muscle
- Exercise mitigates the Toll of muscle atrophy: a narrative review of the effects of exercise on Toll-like receptor-4 in leukocytes and skeletal muscle
- The effect of prolonged interval and continuous exercise in the heat on circulatory markers of intestinal barrier integrity
- The combined effects of exercise-induced muscle damage and heat stress on acute kidney stress and heat strain during subsequent endurance exercise
- Stimulated myotube contractions regulate membrane-bound and soluble TLR4 to prevent LPS-induced signaling and myotube atrophy in skeletal muscle cells
Showing 5 of 14 shared publications
- High-altitude exposures and intestinal barrier dysfunction
- Exercise mitigates the Toll of muscle atrophy: a narrative review of the effects of exercise on Toll-like receptor-4 in leukocytes and skeletal muscle
- The effect of prolonged interval and continuous exercise in the heat on circulatory markers of intestinal barrier integrity
- Strategies to mitigate acute kidney injury risk during physical work in the heat
- Stimulated myotube contractions regulate membrane-bound and soluble TLR4 to prevent LPS-induced signaling and myotube atrophy in skeletal muscle cells
Showing 5 of 14 shared publications
- Age alters the thermoregulatory responses to extreme heat exposure with accompanying activities of daily living
- Aging Increases Enterocyte Damage during a 3-Hour Exposure to Very Hot and Dry Heat: A Preliminary Study
- Gastrointestinal permeability and kidney injury risk during hyperthermia in young and older adults
- Kidney Function Biomarkers During Extreme Heat Exposure in Young and Older Adults
- Identifying the Optimal Heat Exposure Metric for Predicting the Physiological Response to Dry or Humid Heat Stress in Young and Older Adults: A Randomized Controlled Study
Showing 5 of 12 shared publications
- Repeated sprint exercise in hypoxia stimulates HIF-1-dependent gene expression in skeletal muscle
- Change in Exercise Performance and Markers of Acute Kidney Injury Following Heat Acclimation with Permissive Dehydration
- The combined effects of exercise-induced muscle damage and heat stress on acute kidney stress and heat strain during subsequent endurance exercise
- Stimulated myotube contractions regulate membrane-bound and soluble TLR4 to prevent LPS-induced signaling and myotube atrophy in skeletal muscle cells
- Effect of heat stress on heat shock protein expression and hypertrophy-related signaling in the skeletal muscle of trained individuals
Showing 5 of 11 shared publications
- Age alters the thermoregulatory responses to extreme heat exposure with accompanying activities of daily living
- Kidney Function Biomarkers During Extreme Heat Exposure in Young and Older Adults
- Exercise and Heat Stress in Well-Healed Burn Survivors: Effects of Cooling Modalities on Thermal and Perceptual Responses
- Cardiac responses to environmental heat exposure in young and older adults
- Low-dose sufentanil does not affect tolerance to LBNP-induced central hypovolemia or blood pressure responses during a cold pressor test
Showing 5 of 11 shared publications
- Age alters the thermoregulatory responses to extreme heat exposure with accompanying activities of daily living
- Kidney Function Biomarkers During Extreme Heat Exposure in Young and Older Adults
- Exercise and Heat Stress in Well-Healed Burn Survivors: Effects of Cooling Modalities on Thermal and Perceptual Responses
- Cardiac responses to environmental heat exposure in young and older adults
- Sex Differences in Sympathetic Responses to Lower-Body Negative Pressure
Showing 5 of 8 shared publications
- The effect of prolonged interval and continuous exercise in the heat on circulatory markers of intestinal barrier integrity
- The Potential Role of Exercise-Induced Muscle Damage in Exertional Heat Stroke
- Strategies to mitigate acute kidney injury risk during physical work in the heat
- The combined effects of exercise-induced muscle damage and heat stress on acute kidney stress and heat strain during subsequent endurance exercise
- Autophagy in peripheral blood mononuclear cells is associated with body fat percentage
Showing 5 of 7 shared publications
- The effect of interval and continuous work on markers of acute kidney injury in a hot environment
- Effect of heat stress on heat shock protein expression and hypertrophy-related signaling in the skeletal muscle of trained individuals
- Circulating markers of intestinal barrier injury and inflammation following exertion in hypobaric hypoxia
- Ibuprofen Increases Markers of Intestinal Barrier Injury But Suppresses Inflammation at Rest and After Exercise in Hypoxia
- Impact of Maternal Exercise on Mice Offspring Development, Pulmonary Hypertension, and Vascular Remodeling in Chronic Hypoxia
Showing 5 of 7 shared publications
- Cardiac remodeling in well-healed burn survivors after 6 months of unsupervised progressive exercise training
- Sex Differences in Sympathetic Responses to Lower-Body Negative Pressure
- Attrition of Well-Healed Burn Survivors to a 6-Month Community-Based Exercise Program: A Retrospective Evaluation
- Sex differences in autonomic and cardiovascular responses during lower-body negative pressure
- Cardiac Remodeling In Well-healed Burn Survivors After Six Months Of Unsupervised Progressive Exercise Training
Showing 5 of 7 shared publications
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