Jeffrey S. Brown

OverviewAI-generated summary

Jeffrey S. Brown's research focuses on the development and application of real-world evidence (RWE) methodologies, particularly using electronic health records (EHRs) for public health surveillance and informing regulatory and coverage decisions. He has contributed to the expansion of the US Food and Drug Administration's Sentinel System, a national resource designed to create a learning health system by integrating diverse data sources for causal analysis frameworks. His work has explored methods for transforming raw data into analytical datasets suitable for RWE studies.

Brown has investigated the reproducibility of RWE studies and the challenges associated with aggregating EHR data, emphasizing the need for careful consideration of data quality and analytical approaches. His publications also touch on the characteristics of patient populations in specific therapeutic areas, such as new adult users of mepolizumab for asthma in the USA, and the adaptation of public health surveillance systems for emerging health threats like COVID-19. His research enterprise, the FDA Sentinel Real World Evidence Data Enterprise (RWE-DE), aims to enhance the capability to generate RWE from large-scale healthcare data.

With an h-index of 55, over 323 publications, and more than 11,000 citations, Brown's scholarly contributions are extensive. His recent work, including publications in 2024 and 2022, indicates continued activity in the field of real-world evidence generation and its application in healthcare and regulatory science.

Metrics

• h-index: 55
• Publications: 323
• Citations: 11,469