Paul E. Gottschall
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Also affiliated: Semmelweis University (1990); Tulane University (1986–2008); University of Hawaiʻi at Mānoa (2001); National Institutes of Health (2012); Beth Israel Deaconess Medical Center (2001); University of Hawaii System (2001); Harvard University (2001); Heidelberg University (2012); University of South Florida (1993–2010); University of California San Diego (1984); National Institute of Environmental Health Sciences (2012); Queen's Medical Center (2001); Shriners Hospitals for Children - Tampa (2005); Nagoya University (1991); University of South Alabama (1990); Michigan State University (1982–2008); Universidad Nacional Autónoma de México (2001); Saarland University (2012)
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Biography and Research Information
OverviewAI-generated summary
Paul E. Gottschall's research has focused on the neuroendocrine and inflammatory responses involved in physiological and pathological processes. His work has investigated the roles of cytokines, such as Interleukin-1, in stimulating the release of adrenocorticotropic hormone (ACTH), exploring the indirect mechanisms and potential involvement of prostaglandins in these pathways. Further research has examined the distribution and function of binding sites for pituitary adenylate cyclase-activating polypeptide (PACAP) in various tissues, including the brain.
Gottschall has also studied the regulation of matrix metalloproteinases (MMPs) in glial cells, specifically astrocytes and microglia, and their interaction with neurons. This includes investigating how cytokines influence the activity of gelatinases like MMP-2 and MMP-9 in cultured rat astrocytes. His earlier work explored the potential of Aβ peptide vaccination as a strategy to prevent memory loss in animal models of Alzheimer's disease.
With an h-index of 50, 107 total publications, and over 8,500 citations, Gottschall is recognized as a highly cited researcher. He leads a research group and has been recently active, with his most recent publication in 2017.
Metrics
- h-index: 50
- Publications: 107
- Citations: 8,513
Selected Publications
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Neuronal cells derived from human induced pluripotent stem cells as a functional tool of melanocortin system (2017)
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Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice (2015)
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ADAMTS expression and function in central nervous system injury and disorders (2015)
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Altered Synaptic Marker Abundance in the Hippocampal Stratum Oriens of Ts65Dn Mice is Associated with Exuberant Expression of Versican (2012)
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Selective Decline of Synaptic Protein Levels in the Frontal Cortex of Female Mice Deficient in the Extracellular Metalloproteinase ADAMTS1 (2012)
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Lectican proteoglycans, their cleaving metalloproteinases, and plasticity in the central nervous system extracellular microenvironment (2012)
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Canonical Transient Receptor Channel 5 (TRPC5) and TRPC1/4 Contribute to Seizure and Excitotoxicity by Distinct Cellular Mechanisms (2012)
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Important role for endothelial calveolin‐1 in focal cerebral ischemia‐induced blood–brain barrier injury (2011)
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Trafficking CD11b-Positive Blood Cells Deliver Therapeutic Genes to the Brain of Amyloid-Depositing Transgenic Mice (2010)
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Panel of synaptic protein ELISAs for evaluating neurological phenotype (2010)
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Abnormal post‐translational and extracellular processing of brevican in plaque‐bearing mice over‐expressing APPsw (2010)
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Inhibition of gelatinase activity reduces neural injury in an ex vivo model of hypoxia–ischemia (2009)
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Discordant localization of WFA reactivity and brevican/ADAMTS-derived fragment in rodent brain (2008)
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Delayed administration of a matrix metalloproteinase inhibitor limits progressive brain injury after hypoxia-ischemia in the neonatal rat (2008)
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Adeno-associated Viral (AAV) Serotype 5 Vector Mediated Gene Delivery of Endothelin-converting Enzyme Reduces Aβ Deposits in APP + PS1 Transgenic Mice (2008)
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