Tuhin Virmani
Associate Professor
Also affiliated: Washington University in St. Louis (2011); Columbia University Irving Medical Center (2013); University of Arkansas Medical Center (2019–2022); Neurology, Inc (2021); Columbia University (2012–2016); The University of Texas Southwestern Medical Center (2003–2007)
Neurology, College of Medicine
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Tuhin Virmani's research focuses on the neurological mechanisms underlying movement disorders, particularly Parkinson disease. His work has explored the physiological processes of neuronal communication, including the role of neurotransmitters at the synapse. Dr. Virmani investigated the clinicopathological characteristics of freezing of gait in Parkinson disease through autopsy-confirmed studies. He has also examined the interaction between dietary protein and levodopa in motor fluctuations experienced by Parkinson disease patients.
His early research contributed to understanding synaptic vesicle recycling and the cell-autonomous roles of specific proteins in synapse establishment. More recently, Dr. Virmani has investigated the application of machine learning methods for the identification of Parkinson disease through voice sample analysis. He maintains an active laboratory and has a significant publication record, with an h-index of 21 and over 1,655 citations. Dr. Virmani collaborates with several researchers at the University of Arkansas for Medical Sciences, including Lakshmi Pillai, Aliyah Glover, Linda Larson-Prior, and Aaron S. Kemp.
Research Overview
Dr. Virmani completed his medical training at UT Southwestern Medical School in Dallas where he was in the Medical Scientist Training Program (MSTP) receiving a combined M.D/Ph.D degree. His research in basic neuroscience explored the physiologic mechanisms by which neurons in the brain communicate with one other using chemical neurotransmitters at the synapse. He then went on to pursue a residency in Neurology at Washington University in St. Louis where he developed an interest in Movement Disorders. This lead to a two year combined clinical-research fellowship in Movement Disorders under the guidance of Dr. Stanley Fahn and other members of the Center for Parkinson Disease and other Movement Disorders at Columbia University Medical Center in New York. While at Columbia University, Dr. Virmani became interested in the principles underlying the phenomenon of freezing of gait in Parkinson disease and he undertook a clinicopathologic study under the mentorship of Dr. Fahn and Dr. Jean-Paul Vonsattel (Department of Pathology). He also worked with Dr. Fahn to start a clinical trial using a novel motor-neuronotrophic factor for potential neuroprotection in Parkinson disease. This trial is currently underway. In addition to his clinical duties as the Director of the Movement Disorders program at UAMS, Dr. Virmani plans to continue to develop his research interests with the establishment of a gait lab and eventual participation in national clinical research trials.
Metrics
- h-index: 21
- Publications: 87
- Citations: 1,660
Positions
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Associate Professor, Director Movement Disorders Neurology Program 2019–presentUniversity of Arkansas for Medical Sciences Neurology ORCID
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Associate Professor publications 2014–2026University of Arkansas for Medical Sciences Neurology, College of Medicine Institutional directory
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Assistant Professor, Director Movement Disorders Program 2013–2019University of Arkansas for Medical Sciences Neurology ORCID
Selected Publications
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Author Correction: A machine learning method to process voice samples for identification of Parkinson’s disease (2026)
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Multimodal mapping of balance dysfunction in Parkinson's disease: a consensus roadmap for research and intervention (2026)
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Use of a Binary Logistic Regression Model to Categorize People with Parkinson’s Disease as Freezers or Non-freezers (P9-17.006) (2026)
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Time to Freeze: Development of OFF ‐ and OFFON ‐State Freezing of Gait in Parkinson's Disease (2026)
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Voice and Speech in Atypical Parkinsonian Disorders (2026)
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An updated definition of freezing of gait (2026)
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Pearls & Oy-sters: Hereditary Spastic Paraplegia Type 15 Presenting as Juvenile Onset Levodopa-Responsive Parkinsonism (2026)
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A qualitative approach to extract diagnostic patterns of cognitive impairment in Parkinson’s disease (2026)
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Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease (2025)
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Exploring the relationship between orthostatic hypotension and gait in people with Parkinson’s disease (2025)
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Levodopa influence on turning dynamics in people with Parkinson’s disease (2025)
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Longitudinal Monitoring of Digitized Cursive Writing in People with Parkinson’s Disease Shows Increased Variability in Absolute Jerk and Decreased Writing Duration in Those with Freezing of Gait (P9-5.019) (2025)
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Pre-trained convolutional neural networks identify Parkinson’s disease from spectrogram images of voice samples (2025)
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Pre-trained Convolutional Neural Networks Identify Parkinson’s Disease from Spectrogram Images of Voice Samples (2024)
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Levodopa influence on turning dynamics in people with Parkinson’s disease (2024)
Grants & Funding
As listed on this researcher's institutional profile.
- Gut-microbiota-metabolite cross-talk in neuropsychiatric symptoms of Parkinson's Disease UAMS Principal Investigator
- TCIA Sustainment and Scalability - Platforms for Quantitative Imaging Informatics in Precision Medicine NIH Co-Investigator
- Gait Physiology as a non-invasive biomarker for Freezing of Gait in Parkinson’s Disease UAMS Principal Investigator
- Machine Learning Approaches for Remote Pathological Speech Assessment for Parkinson’s Disease NSF/EPSCoR Co-Investigator
- Comparison of different health care delivery methods in a rural underserved population of People with Parkinson’s Disease NIH/NCATS Principal Investigator
- Utilization of a Neuroinformatics Research Platform (ARIES) to Develop Quantitative Tools for Clinical Assessment and Treatment of Parkinson’s Disease Patients in Rural Arkansas NIH/NCATS UL1TR003107 Principal Investigator
- Gamified quantification of normal and pathological movement using 2D and Virtual Reality and Haptic sensing for therapeutic efficacy and disease progression in movement disorders NIH/NCATS Co-Investigator
- ABI C. OBrien NIH COBRE FY26 Y4 State of Arkansas Principal Investigator
- Modafinil as a novel treatment for freezing of gait in Parkinson’s disease NIGMS Principal Investigator
- Freezing of gait in Parkinson's disease: From development of predictive algorithms to testing novel therapeutics Parkinson's Foundation Principal Investigator
- Phone-Collected Speech Corpus for Remote Assessment of Parkinson's Disease UAMS Co-Investigator
Collaboration Network
Top Collaborators
- A machine learning method to process voice samples for identification of Parkinson’s disease
- Increased foot strike variability in Parkinson's disease patients with freezing of gait
- Impaired step‐length setting prior to turning in Parkinson's disease patients with freezing of gait
- Feasibility of telemedicine research visits in people with Parkinson’s disease residing in medically underserved areas
- Pre-trained convolutional neural networks identify Parkinson’s disease from spectrogram images of voice samples
Showing 5 of 37 shared publications
- A machine learning method to process voice samples for identification of Parkinson’s disease
- Impaired step‐length setting prior to turning in Parkinson's disease patients with freezing of gait
- Feasibility of telemedicine research visits in people with Parkinson’s disease residing in medically underserved areas
- Levodopa ONOFF-state freezing of gait: Defining the gait and non-motor phenotype
- Differential Gait Decline in Parkinson’s Disease Enhances Discrimination of Gait Freezers from Non-Freezers
Showing 5 of 27 shared publications
- A machine learning method to process voice samples for identification of Parkinson’s disease
- Increased foot strike variability in Parkinson's disease patients with freezing of gait
- Virtual Reality in the Neurosciences: Current Practice and Future Directions
- Objective measures of gait and balance in healthy non-falling adults as a function of age
- Impaired step‐length setting prior to turning in Parkinson's disease patients with freezing of gait
Showing 5 of 20 shared publications
- A machine learning method to process voice samples for identification of Parkinson’s disease
- Feasibility of telemedicine research visits in people with Parkinson’s disease residing in medically underserved areas
- Pre-trained convolutional neural networks identify Parkinson’s disease from spectrogram images of voice samples
- Semantic Integration of Multi-Modal Data and Derived Neuroimaging Results Using the Platform for Imaging in Precision Medicine (PRISM) in the Arkansas Imaging Enterprise System (ARIES)
- Amplitude setting and dopamine response of finger tapping and gait are related in Parkinson’s disease
Showing 5 of 13 shared publications
- A machine learning method to process voice samples for identification of Parkinson’s disease
- Feasibility of telemedicine research visits in people with Parkinson’s disease residing in medically underserved areas
- Pre-trained convolutional neural networks identify Parkinson’s disease from spectrogram images of voice samples
- Semantic Integration of Multi-Modal Data and Derived Neuroimaging Results Using the Platform for Imaging in Precision Medicine (PRISM) in the Arkansas Imaging Enterprise System (ARIES)
- Gait Declines Differentially in, and Improves Prediction of, People with Parkinson’s Disease Converting to a Freezing of Gait Phenotype
Showing 5 of 9 shared publications
- Levodopa ONOFF-state freezing of gait: Defining the gait and non-motor phenotype
- Gait Declines Differentially in, and Improves Prediction of, People with Parkinson’s Disease Converting to a Freezing of Gait Phenotype
- Levodopa responsive gait dynamics in OFF- and ONOFF-state freezing of gait in Parkinson’s disease
- Levodopa influence on turning dynamics in people with Parkinson’s disease
- Levodopa Responsive Gait Dynamics in OFF- And ONOFF-State Freezing of Gait in Parkinson's Disease
Showing 5 of 9 shared publications
- Feasibility of telemedicine research visits in people with Parkinson’s disease residing in medically underserved areas
- Amplitude setting and dopamine response of finger tapping and gait are related in Parkinson’s disease
- Utility of objective gait measures in levodopa‐unresponsive freezing in Parkinson's
- Feasibility of regional center telehealth visits utilizing a rural research network in people with Parkinson’s disease
- Objective Markers of Finger Tapping in Idiopathic Parkinson’s Disease with Freezing of Gait (4468)
Showing 5 of 8 shared publications
- Amplitude setting and dopamine response of finger tapping and gait are related in Parkinson’s disease
- Feasibility of regional center telehealth visits utilizing a rural research network in people with Parkinson’s disease
- Objective Markers of Finger Tapping in Idiopathic Parkinson’s Disease with Freezing of Gait (4468)
- Development and implementation of the frog-in-maze game to study upper limb movement in people with Parkinson’s disease
- Amplitude setting and dopamine response of finger tapping and gait are related in Parkinson’s disease
Showing 5 of 6 shared publications
- A machine learning method to process voice samples for identification of Parkinson’s disease
- Feasibility of telemedicine research visits in people with Parkinson’s disease residing in medically underserved areas
- Pre-trained convolutional neural networks identify Parkinson’s disease from spectrogram images of voice samples
- A Machine Learning Method to Process Voice Samples for Identification of Parkinson’s Disease
- Pre-trained Convolutional Neural Networks Identify Parkinson’s Disease from Spectrogram Images of Voice Samples
Showing 5 of 6 shared publications
- Increased foot strike variability in Parkinson's disease patients with freezing of gait
- Impaired step‐length setting prior to turning in Parkinson's disease patients with freezing of gait
- Levodopa ONOFF-state freezing of gait: Defining the gait and non-motor phenotype
- Differential Gait Decline in Parkinson’s Disease Enhances Discrimination of Gait Freezers from Non-Freezers
- Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
- Increased foot strike variability in Parkinson's disease patients with freezing of gait
- Impaired step‐length setting prior to turning in Parkinson's disease patients with freezing of gait
- Arousal and the control of perception and movement.
- The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics
- Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
- Olfactory Deficits in the Freezing of Gait Phenotype of Parkinson's Disease
- Utility of objective gait measures in levodopa‐unresponsive freezing in Parkinson's
- Voice and Speech in Atypical Parkinsonian Disorders
- A qualitative approach to extract diagnostic patterns of cognitive impairment in Parkinson’s disease
- Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
- Amplitude setting and dopamine response of finger tapping and gait are related in Parkinson’s disease
- Objective Markers of Finger Tapping in Idiopathic Parkinson’s Disease with Freezing of Gait (4468)
- Archimedes Spiral Drawing in Idiopathic Parkinson’s Disease Patients Showed More Variability in Jerkiness in Patients with Freezing of Gait (4882)
- Amplitude setting and dopamine response of finger tapping and gait are related in Parkinson’s disease
- Objective Markers of Foot Tapping in Idiopathic Parkinson’s Disease with Freezing of Gait (4609)
- A splice site mutation in ATP6AP2 causes X-linked intellectual disability, epilepsy, and parkinsonism
- Objective measures of gait and balance in healthy non-falling adults as a function of age
- Clinical Reasoning: A 73-year-old man with diplopia and ataxia
- Double Dose Contrast in CLIPPERS: Key to Biopsy? (P6.123)
- Toxic Myopathy due to Antidopaminergic Medication Without Neuroleptic Malignant Syndrome
- Glioblastoma, IDH ‐Wildtype, CNS WHO Grade 4, Associated with Deep Brain Stimulation in a Patient with Essential Tremor: Report of a Case with Molecular Characterization, and Review of the Literature
- Clinical Reasoning: A 73-year-old man with diplopia and ataxia
- Anti-dopaminergic medication related myopathy causing respiratory muscle weakness without neuroleptic malignant syndrome (P3.461)
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