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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-08
A
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Alex Lagasse investigates molecular mechanisms regulating pituitary gland function, with a focus on the impact of diet and hormonal signaling on gene expression and cellular metabolism. Research has explored the effects of high-fat diets on anterior pituitary transcriptomics, particularly concerning oxidative stress and cell metabolism in female mice. Studies have also examined the role of RNA-binding proteins, such as Musashi, in controlling mRNA translation in gonadotropes during the mouse estrous cycle. Further work has investigated the influence of leptin receptor signaling on somatotrope transcriptome maturation and the effects of maternal undernutrition on offspring transcript changes, potentially influencing diet-induced weight gain resistance. Collaborations include extensive work with Angus M. MacNicol, Angela K. Odle, Gwen V. Childs, and Melanie C MacNicol at the University of Arkansas for Medical Sciences.
Metrics
- h-index: 5
- Publications: 21
- Citations: 82
Selected Publications
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ELAVL1 and ELAVL4 Are Required for Musashi-Dependent Translational Activation (2026)
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ELAVL1 and ELAVL4 are required for Musashi-dependent translational activation (2026)
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Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations (2026)
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Secretogranin II–derived peptide secretoneurin differentially stimulates luteinizing hormone secretion by age and sex in ex vivo murine pituitaries (2026)
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OR13-08 Secretoneurin Modulates Gonadotrope Function Cyclically to Regulate LH Secretion (2025)
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SAT-001 Impact of VCD-induced Menopause on Gonadotrope Transcriptomics Reveals Estrogen-dependent Genes in the GnRH Signaling Pathway (2025)
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High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes (2025)
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Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice (2025)
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8572 A 30% Maternal Caloric Restriction Alters Expression of Musashi Targets in the Neonatal and Adult Pituitary Proteomes of FVB Mice (2024)
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8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells (2024)
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The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs (2024)
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Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain (2024)
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Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism (2023)
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FRI289 It Takes A Village: Musashi And Its Associated Proteins In The Adenohypophysis (2023)
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FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes (2023)
Collaboration Network
Top Collaborators
Melanie C MacNicol
University of Arkansas for Medical Sciences
13 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
Showing 5 of 13 shared publications
Gwen V. Childs
University of Arkansas for Medical Sciences
13 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
Showing 5 of 13 shared publications
Angus M. MacNicol
University of Arkansas for Medical Sciences
13 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
Showing 5 of 13 shared publications
Angela K. Odle
University of Arkansas for Medical Sciences
13 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
Showing 5 of 13 shared publications
Anessa Haney
University of Arkansas for Medical Sciences
11 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
Showing 5 of 11 shared publications
Tiffany K. Miles
Arkansas Children's Hospital
11 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- THU043 Single-cell Transcriptomics Show Sex-specific Responses To A High Fat Diet, Under Thermoneutral Conditions, Pointing To Reduced Pituitary Plasticity
Showing 5 of 11 shared publications
Ashley Herdman
University of Arkansas for Medical Sciences
8 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
- 8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
Showing 5 of 8 shared publications
Stephanie D. Byrum
St. Jude Children's Research Hospital
6 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
- 8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells
Showing 5 of 6 shared publications
Victoria G Ortega
University of Arkansas for Medical Sciences
5 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- 8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells
- 8572 A 30% Maternal Caloric Restriction Alters Expression of Musashi Targets in the Neonatal and Adult Pituitary Proteomes of FVB Mice
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
Ulrich Boehm
Saarland University (DE)
4 shared publications
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- OR13-08 Secretoneurin Modulates Gonadotrope Function Cyclically to Regulate LH Secretion
- Secretogranin II–derived peptide secretoneurin differentially stimulates luteinizing hormone secretion by age and sex in ex vivo murine pituitaries
Stephanie D. Byrum
University of Arkansas for Medical Sciences
4 shared publications
In database
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- 8572 A 30% Maternal Caloric Restriction Alters Expression of Musashi Targets in the Neonatal and Adult Pituitary Proteomes of FVB Mice
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
- SAT-001 Impact of VCD-induced Menopause on Gonadotrope Transcriptomics Reveals Estrogen-dependent Genes in the GnRH Signaling Pathway
Ana Rita Silva Moreira
University of Arkansas for Medical Sciences (US)
3 shared publications
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
Jewel Banik
University of Arkansas for Medical Sciences
3 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
Allen Gies
University of Arkansas for Medical Sciences
3 shared publications
In database
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- 8572 A 30% Maternal Caloric Restriction Alters Expression of Musashi Targets in the Neonatal and Adult Pituitary Proteomes of FVB Mice
Juchan Lim
University of Arkansas for Medical Sciences
2 shared publications
In database
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
Similar Researchers
Based on overlapping research topics
Victoria G Ortega
University of Arkansas for Medical Sciences
Receptor Mechanisms and Signaling
Diet and metabolism studies
Animal, Disease Models
Anessa Haney
University of Arkansas for Medical Sciences
Receptor Mechanisms and Signaling
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Animal, Disease Models
Tiffany K. Miles
University of Arkansas for Medical Sciences
Receptor Mechanisms and Signaling
Diet and metabolism studies
Animal, Disease Models
Milla M Reddick
University of Arkansas for Medical Sciences
Diet and metabolism studies
RNA and protein synthesis mechanisms
Animal, Disease Models
Margaret A. Carroll
University of Arkansas for Medical Sciences
Receptor Mechanisms and Signaling
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Sakura Rieck
University of Arkansas at Fayetteville
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