Mitochondrial Function And Pathology

239 researchers across 10 institutions

239 Researchers
10 Institutions
23 Grant PIs
62 High Impact

Research in mitochondrial function and pathology investigates the central role of mitochondria in cellular energy production, metabolism, and cell death. Studies explore how mitochondrial dysfunction contributes to a range of diseases, including neurodegenerative disorders, metabolic syndromes, cardiovascular conditions, and cancer. Investigations employ techniques such as genetic analysis, biochemical assays, advanced microscopy, and cellular models to understand mitochondrial dynamics, biogenesis, and the impact of genetic mutations or environmental factors on mitochondrial health. This area also examines therapeutic strategies aimed at restoring or enhancing mitochondrial function.

The health and metabolic status of Arkansans are directly impacted by research in mitochondrial function. Understanding how diet, environmental exposures, and inherited predispositions affect mitochondrial health is crucial for addressing prevalent public health challenges within the state, such as diabetes and obesity. Furthermore, insights from this research can inform the development of agricultural practices and the assessment of environmental toxins, potentially impacting natural resource management and economic sectors reliant on public health.

This research area draws on expertise from molecular biology, genetics, pharmacology, and biochemistry. Connections extend to studies of metabolism and genetic disorders, disease mechanisms, cancer research, and immune responses. Engagement spans multiple institutions across Arkansas, fostering collaborative efforts to advance scientific understanding and address health-related issues.

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Top Researchers

Name Institution h-index Citations Career Stage Badges
Zhong Chen University of Arkansas 104 46,092
Stavros C. Manolagas UAMS 85 28,940 High Impact
Syed F. Ali NCTR 75 20,814 High Impact
W. Sue T. Griffin UAMS 65 17,454 Grant PI High Impact
Jeanne Y. Wei UAMS 56 14,200 High Impact
Maria Almeida UAMS 54 11,482 Grant PI High Impact
Gerald A. Dienel UAMS 47 10,533 High Impact
Dan A. Dixon UAMS 46 8,486 High Impact
Mitchell R. McGill UAMS 45 9,594 Grant PI High Impact
Robert J. Shmookler Reis UAMS 44 5,694 Grant PI High Impact
Jorge Guerrero UAMS 44 7,281 High Impact
Francis Millett University of Arkansas 42 4,772 High Impact
Nancy J. Rusch UAMS 42 4,961 High Impact
Michael L. Jennings UAMS 40 4,870 High Impact
Judit Megyesi UAMS 40 4,940 High Impact
Philip Palade UAMS 39 5,103 High Impact
Si Chen NCTR 39 4,729 High Impact
Nadine Hempel UAMS 39 4,929
Jeffrey D. Silberman University of Arkansas 38 4,130 High Impact
Mark Roberts UAMS 38 5,813 High Impact
Metabolism And Genetic Disorders 90 Disease Mechanisms Research 82 Pharmacological Effects And Toxicity Studies 53 Cancer-Related Molecular Mechanisms Research 50 Molecular Biology Techniques And Applications 43 Diet And Metabolism Studies 42 Immune Response And Inflammation 41 Protein Structure And Dynamics 30 Genomics And Phylogenetic Studies 30 Neuroscience And Neuropharmacology Research 28 Muscle Physiology And Disorders 26 Cellular Transport And Secretion 25 Animal Behavior And Welfare Studies 24 Cardiovascular Function And Risk Factors 23 Neurological Disorders And Treatments 22

Connected Research Areas

Topics that share active collaborators with Mitochondrial Function And Pathology in Arkansas. Pairs are ranked by collaboration density relative to expected co-authorship under a random null. This describes existing connections, not investment recommendations.

Strategic Outlook

Global signals from OpenAlex for this research area: where the field is growing, how concentrated leadership is, and where Arkansas sits relative to the world's top-100 institutions. Descriptive only — surfaced as input to the conversation about where to place bets, not a recommendation. Signal confidence: LOW

Global trajectory
12,623 works in 2025
+2.3% CAGR 2018–2025
Leadership concentration
5.6% held by global top 5 institutions
Fragmented HHI 19
Arkansas position
Arkansas not in global top 100
No AR institution among the top-100 contributors to this topic over the 2018–2025 window.

Top US institutions in this area

  1. 1 Harvard University 3,757
  2. 2 Johns Hopkins University 3,027
  3. 3 National Institutes of Health 2,668
  4. 4 University of Pennsylvania 2,525
  5. 5 Johns Hopkins Medicine 1,955

Cross-Institution Connections

Researchers at different institutions with overlapping expertise in Mitochondrial Function And Pathology.

J.C. Hsu UAMS
67%
William B. Mattes NCTR
Colten Nichols UA Div. of Agriculture
65%
K.C. Grishma UAMS
Tu, Shi-Ming UAMS
58%
Logan Waddle University of Arkansas
Yali Huang UAMS
58%
Wenwen Ding University of Arkansas
Antino Allen University of Arkansas
56%
Haven Griffin UAMS
Bachkhoa Nguyen UAMS
56%
Shilpa Iyer University of Arkansas
Lee Ann MacMillan‐Crow UAMS
54%
Hannah Stovall Hendrix College
Antino Allen University of Arkansas
54%
Grishma KC UAMS
Srinivas Ayyadevara UAMS
54%
Michelle Gray University of Arkansas
Bachkhoa Nguyen UAMS
54%
Joseph Chihade University of Arkansas

Researchers with Federal Grants

Mark Manzano UAMS 4 grants Maria Almeida UAMS 3 grants Adam C. Paré University of Arkansas 2 grants Abdelrahman Y. Fouda UAMS 2 grants Antiño R. Allen UAMS 2 grants Seongkyun Lim University of Arkansas 2 grants Ha‐Neui Kim UAMS 2 grants Nicholas P. Greene University of Arkansas 1 grant Robert J. Shmookler Reis UAMS 1 grant Jinhu Xiong UAMS 1 grant W. Sue T. Griffin UAMS 1 grant Tyrone A. Washington University of Arkansas 1 grant Mitchell R. McGill UAMS 1 grant Nirmala Parajuli UAMS 1 grant Andrew D. Sweet Arkansas State University 1 grant Srinivas Ayyadevara UAMS 1 grant Sue Griffin UAMS 1 grant Rupak Pathak UAMS 1 grant Kari Naylor University of Central Arkansas 1 grant Shilpa Iyer University of Arkansas 1 grant
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