Stewart L. MacLeod

High Impact

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UAMS

Also affiliated: Merck & Co., Inc., Rahway, NJ, USA (United States) (1991); Arkansas Children's Hospital (2010–2014); Medical University of South Carolina (1991); Central Arkansas Veterans Healthcare System (2008); Centers for Disease Control and Prevention (2010); Eunice Kennedy Shriver National Institute of Child Health and Human Development (2010); Arkansas Biosciences Institute (2010); John L. McClellan Memorial Veterans Hospital (1990); Arkansas Children's Research Institute (2010–2021); The University of Texas at San Antonio (1991)

21 h-index 45 pubs 1,635 cited

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OverviewAI-generated summary

Stewart L. MacLeod's research focuses on the genetic and molecular underpinnings of congenital heart disease (CHD). His work investigates the interplay between genetic variations, epigenetic modifications, and environmental factors, such as folic acid intake, in the development of these conditions. MacLeod has published research exploring methylation quantitative trait loci (mQTLs) in cardiac tissues, identifying potential risk loci and biological pathways relevant to CHD. This research also nominated specific genes and pathways involved in cardiac development and disease.

His investigations have included case-control studies utilizing data from the National Birth Defects Prevention Study. These studies examine gene-folic acid interactions and their association with the risk of specific CHD subtypes, such as conotruncal heart defects. MacLeod leads a research group at the University of Arkansas for Medical Sciences and collaborates with other researchers, including Christopher E. Randolph, on shared publications. His scholarship metrics include an h-index of 20, with 43 total publications and 1,595 total citations, designating him as a highly cited researcher.

Metrics

h-index: 21
Publications: 45
Citations: 1,635

Selected Publications

Gene–Folic Acid Interactions and Risk of Conotruncal Heart Defects: Results from the National Birth Defects Prevention Study (2023)

Genes 7 citations DOI OpenAlex
A parent‐of‐origin analysis of paternal genetic variants and increased risk of conotruncal heart defects (2018)

American Journal of Medical Genetics Part A 9 citations DOI OpenAlex
Testing Allele Transmission of an SNP Set Using a Family‐Based Generalized Genetic Random Field Method (2016)

Genetic Epidemiology 3 citations DOI OpenAlex
A Three-Way Interaction among Maternal and Fetal Variants Contributing to Congenital Heart Defects (2015)

Annals of Human Genetics 11 citations DOI OpenAlex
Developments in our understanding of the genetic basis of birth defects (2015)

Birth Defects Research Part A Clinical and Molecular Teratology 46 citations DOI OpenAlex
Krüppel-like factor 9 (KLF9) prevents colorectal cancer through inhibition of interferon-related signaling (2015)

Carcinogenesis 60 citations DOI OpenAlex
Obstructive heart defects associated with candidate genes, maternal obesity, and folic acid supplementation (2015)

American Journal of Medical Genetics Part A 40 citations DOI OpenAlex
Genetic variation affects congenital heart defect susceptibility in offspring exposed to maternal tobacco use (2015)

Birth Defects Research Part A Clinical and Molecular Teratology 17 citations DOI OpenAlex
Genetic Epidemiology and Nonsyndromic Structural Birth Defects (2014)

Archives of Pediatrics and Adolescent Medicine 54 citations DOI OpenAlex
A genetic association study detects haplotypes associated with obstructive heart defects (2014)

Human Genetics 11 citations DOI OpenAlex
Maternal Obesity and Tobacco Use Modify the Impact of Genetic Variants on the Occurrence of Conotruncal Heart Defects (2014)

PLoS ONE 12 citations DOI OpenAlex
Detecting Maternal-Fetal Genotype Interactions Associated With Conotruncal Heart Defects: A Haplotype-Based Analysis With Penalized Logistic Regression (2014)

Genetic Epidemiology 16 citations DOI OpenAlex
Conotruncal heart defects and common variants in maternal and fetal genes in folate, homocysteine, and transsulfuration pathways (2014)

Birth Defects Research Part A Clinical and Molecular Teratology 28 citations DOI OpenAlex
Gene expression profiling in pediatric heart transplant rejection (2013)

International Journal of Cardiology 3 citations DOI OpenAlex
Cheek swabs, SNP chips, and CNVs: Assessing the quality of copy number variant calls generated with subject-collected mail-in buccal brush DNA samples on a high-density genotyping microarray (2012)

BMC Medical Genetics 4 citations DOI OpenAlex