Match tier
Listed
Presence
Current · Arkansas
Last published
2022
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
D
Donald M. Mock
High Impact
Emeritus
Emeritus Professor
Also affiliated: University of Iowa (1985–2012); Brooke Army Medical Center (1985); San Francisco General Hospital (1987); Arkansas Children's Hospital (1993–2004); Maine Medical Center (1998); The University of Texas at San Antonio Health Science Center (1983–1997); University of California, San Francisco (1980–1987); Hormel (United States) (1985); University of Arkansas Medical Center (2004–2015); University of Iowa Hospitals and Clinics (1986–2011); University of California San Diego (1985); University of Texas Health Science Center at Dallas (1975); Maine Medical Center (1998); Iowa City VA Medical Center (2004–2011); University of Iowa Health Care (1988); John L. McClellan Memorial Veterans Hospital (2006); Arkansas Department of Health (2010); Rutgers New Jersey Medical School (1985); Arkansas Children's Research Institute (1996–2001); The University of Texas Southwestern Medical Center (1975)
41 h-index
331 pubs
5,566 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Donald M. Mock's research has focused on the study of biotin and its role in biological systems, particularly concerning red blood cells. His work has investigated how antibodies against biotin-labeled red blood cells can impact their survival after transfusion. Mock has a significant publication record, with over 331 publications and a citation count exceeding 5,500, contributing to his h-index of 41. He is recognized as a highly cited researcher. His collaborations include work with Svetlana V. Kyosseva at the University of Arkansas for Medical Sciences, with whom he has co-authored shared publications. Mock's recent activity indicates ongoing engagement in research, with publications in 2022.
Metrics
- h-index: 41
- Publications: 331
- Citations: 5,566
Positions
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Emeritus Professor publications 1993–2022University of Arkansas for Medical Sciences Institution web page
Selected Publications
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Antibodies against biotin‐labeled red blood cells can shorten posttransfusion survival (2022)
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Biotin (2022)
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Target-mediated disposition population pharmacokinetics model of erythropoietin in premature neonates following multiple intravenous and subcutaneous dosing regimens (2019)
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Overlooked Issues on Pharmacokinetics Data Interpretation of Protein Drugs—a Case Example of Erythropoietin (2018)
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Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced‐based analysis and recommendations (2018)
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In premature infants there is no decrease in 24‐hour posttransfusion allogeneic red blood cell recovery after 42 days of storage (2017)
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Biotin: From Nutrition to Therapeutics (2017)
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Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on red blood cell‐biotin dose (2017)
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Population Pharmacokinetics of Darbepoetin in Infants Following Single Intravenous and Subcutaneous Dosing (2017)
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Estimation of adult and neonatal RBC lifespans in anemic neonates using RBCs labeled at several discrete biotin densities (2017)
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A Novel Physiology-Based Mathematical Model to Estimate Red Blood Cell Lifespan in Different Human Age Groups (2016)
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Clearance of stored red blood cells is not increased compared with fresh red blood cells in a human endotoxemia model (2016)
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Models for the red blood cell lifespan (2016)
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Pharmacokinetics and pharmacodynamics of MD1003 (high-dose biotin) in the treatment of progressive multiple sclerosis (2015)
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Autologous Infant and Allogeneic Adult Red Cells Demonstrate Similar Concurrent Post-Transfusion Survival in Very Low Birth Weight Neonates (2015)
Collaboration Network
Top Collaborators
John A. Widness
University of Iowa (US)
32 shared publications
- Randomized Trial of Liberal Versus Restrictive Guidelines for Red Blood Cell Transfusion in Preterm Infants
- Red blood cell (RBC) survival determined in humans using RBCs labeled at multiple biotin densities
- Measurement of Posttransfusion Red Cell Survival With the Biotin Label
- Models for the red blood cell lifespan
- Posttransfusion 24‐hour recovery and subsequent survival of allogeneic red blood cells in the bloodstream of newborn infants
Showing 5 of 32 shared publications
Ronald G. Strauss
University of Iowa (US)
22 shared publications
- Randomized Trial of Liberal Versus Restrictive Guidelines for Red Blood Cell Transfusion in Preterm Infants
- A randomized clinical trial comparing immediate versus delayed clamping of the umbilical cord in preterm infants: short‐term clinical and laboratory endpoints
- Red blood cell (RBC) survival determined in humans using RBCs labeled at multiple biotin densities
- Measurement of Posttransfusion Red Cell Survival With the Biotin Label
- Posttransfusion 24‐hour recovery and subsequent survival of allogeneic red blood cells in the bloodstream of newborn infants
Showing 5 of 22 shared publications
Nell I. Mock
University of Arkansas for Medical Sciences (US)
20 shared publications
- Marginal biotin deficiency during normal pregnancy
- Marginal Biotin Deficiency Is Teratogenic in ICR Mice
- Indicators of marginal biotin deficiency and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a leucine challenge,,
- Biotin Deficiency Reduces Expression of SLC19A3, a Potential Biotin Transporter, in Leukocytes from Human Blood,
- Disturbances in Biotin Metabolism in Children Undergoing Long-Term Anticonvulsant Therapy
Showing 5 of 20 shared publications
Robert L. Schmidt
University of Iowa (US)
19 shared publications
- Red blood cell (RBC) survival determined in humans using RBCs labeled at multiple biotin densities
- Posttransfusion 24‐hour recovery and subsequent survival of allogeneic red blood cells in the bloodstream of newborn infants
- Estimation of adult and neonatal RBC lifespans in anemic neonates using RBCs labeled at several discrete biotin densities
- Red blood cell (RBC) volume can be independently determined in vivo in humans using RBCs labeled at different densities of biotin
- Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced‐based analysis and recommendations
Showing 5 of 19 shared publications
Anna Bogusiewicz
University of Arkansas for Medical Sciences (US)
18 shared publications
- Urinary Excretion of 3-Hydroxyisovaleric Acid and 3-Hydroxyisovaleryl Carnitine Increases in Response to a Leucine Challenge in Marginally Biotin-Deficient Humans
- Plasma concentration of 3-hydroxyisovaleryl carnitine is an early and sensitive indicator of marginal biotin deficiency in humans
- Quantitative Measurement of Plasma 3-Hydroxyisovaleryl Carnitine by LC-MS/MS as a Novel Biomarker of Biotin Status in Humans
- Lymphocyte propionyl-CoA carboxylase and its activation by biotin are sensitive indicators of marginal biotin deficiency in humans
- Lymphocyte propionyl-CoA carboxylase and its activation by biotin are sensitive indicators of marginal biotin deficiency in humans 1–3
Showing 5 of 18 shared publications
Nell I. Matthews
University of Arkansas for Medical Sciences (US)
17 shared publications
- Red blood cell (RBC) survival determined in humans using RBCs labeled at multiple biotin densities
- Urinary Excretion of 3-Hydroxyisovaleric Acid and 3-Hydroxyisovaleryl Carnitine Increases in Response to a Leucine Challenge in Marginally Biotin-Deficient Humans
- Plasma concentration of 3-hydroxyisovaleryl carnitine is an early and sensitive indicator of marginal biotin deficiency in humans
- Red blood cell (RBC) volume can be independently determined in vivo in humans using RBCs labeled at different densities of biotin
- Measurement of 3-hydroxyisovaleric acid in urine from marginally biotin-deficient humans by UPLC-MS/MS
Showing 5 of 17 shared publications
Janos Zempleni
Arkansas Children's Hospital (US)
17 shared publications
- Marginal Biotin Deficiency Is Teratogenic
- Uptake and metabolism of biotin by human peripheral blood mononuclear cells
- Bioavailability of biotin given orally to humans in pharmacologic doses
- Biotin dependency due to a defect in biotin transport
- In Vivo Biotin Supplementation at a Pharmacologic Dose Decreases Proliferation Rates of Human Peripheral Blood Mononuclear Cells and Cytokine Release
Showing 5 of 17 shared publications
Shawna L. Stratton
University of Arkansas for Medical Sciences (US)
16 shared publications
- Biotin Deficiency Reduces Expression of SLC19A3, a Potential Biotin Transporter, in Leukocytes from Human Blood,
- Smoking accelerates biotin catabolism in women
- Marginal Maternal Biotin Deficiency in CD-1 Mice Reduces Fetal Mass of Biotin-dependent Carboxylases
- Urinary Excretion of 3-Hydroxyisovaleric Acid and 3-Hydroxyisovaleryl Carnitine Increases in Response to a Leucine Challenge in Marginally Biotin-Deficient Humans
- Plasma concentration of 3-hydroxyisovaleryl carnitine is an early and sensitive indicator of marginal biotin deficiency in humans
Showing 5 of 16 shared publications
Demet Nalbant
University of Iowa (US)
14 shared publications
- Red blood cell (RBC) survival determined in humans using RBCs labeled at multiple biotin densities
- Estimation of adult and neonatal RBC lifespans in anemic neonates using RBCs labeled at several discrete biotin densities
- Red blood cell (RBC) volume can be independently determined in vivo in humans using RBCs labeled at different densities of biotin
- Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced‐based analysis and recommendations
- Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on red blood cell‐biotin dose
Showing 5 of 14 shared publications
Peter Veng‐Pedersen
University of Iowa (US)
13 shared publications
- Measurement of Posttransfusion Red Cell Survival With the Biotin Label
- Models for the red blood cell lifespan
- Estimation of adult and neonatal RBC lifespans in anemic neonates using RBCs labeled at several discrete biotin densities
- Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced‐based analysis and recommendations
- A Novel Physiology-Based Mathematical Model to Estimate Red Blood Cell Lifespan in Different Human Age Groups
Showing 5 of 13 shared publications
Gretchen A. Cress
University of Iowa (US)
11 shared publications
- Randomized Trial of Liberal Versus Restrictive Guidelines for Red Blood Cell Transfusion in Preterm Infants
- A randomized clinical trial comparing immediate versus delayed clamping of the umbilical cord in preterm infants: short‐term clinical and laboratory endpoints
- Red blood cell (RBC) survival determined in humans using RBCs labeled at multiple biotin densities
- Posttransfusion 24‐hour recovery and subsequent survival of allogeneic red blood cells in the bloodstream of newborn infants
- Red blood cell (RBC) volume can be independently determined in vivo in humans using RBCs labeled at different densities of biotin
Showing 5 of 11 shared publications
Leon Forrest Burmeister
University of Iowa (US)
9 shared publications
- A randomized clinical trial comparing immediate versus delayed clamping of the umbilical cord in preterm infants: short‐term clinical and laboratory endpoints
- Red blood cell (RBC) volume can be independently determined in vivo in humans using RBCs labeled at different densities of biotin
- RBCs labeled at two biotin densities permit simultaneous and repeated measurements of circulating RBC volume
- Circulating Red Cell Volume and Red Cell Survival Can Be Accurately Determined in Sheep Using the [14C]Cyanate Label
- Red blood cell volume can be independently determined in vitro using sheep and human red blood cells labeled at different densities of biotin
Showing 5 of 9 shared publications
Cindy L Henrich
Clinical Research Management (US)
7 shared publications
- Indicators of marginal biotin deficiency and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a leucine challenge,,
- Urinary Excretion of 3-Hydroxyisovaleric Acid and 3-Hydroxyisovaleryl Carnitine Increases in Response to a Leucine Challenge in Marginally Biotin-Deficient Humans
- Plasma concentration of 3-hydroxyisovaleryl carnitine is an early and sensitive indicator of marginal biotin deficiency in humans
- Lymphocyte propionyl-CoA carboxylase and accumulation of odd-chain fatty acid in plasma and erythrocytes are useful indicators of marginal biotin deficiency☆
- Urinary Excretion of 3-Hydroxyisovaleryl Carnitine Is an Early and Sensitive Indicator of Marginal Biotin Deficiency in Humans,
Showing 5 of 7 shared publications
Thomas D. Horvath
University of Arkansas for Medical Sciences (US)
7 shared publications
- Urinary Excretion of 3-Hydroxyisovaleric Acid and 3-Hydroxyisovaleryl Carnitine Increases in Response to a Leucine Challenge in Marginally Biotin-Deficient Humans
- Plasma concentration of 3-hydroxyisovaleryl carnitine is an early and sensitive indicator of marginal biotin deficiency in humans
- Quantitative Measurement of Plasma 3-Hydroxyisovaleryl Carnitine by LC-MS/MS as a Novel Biomarker of Biotin Status in Humans
- Measurement of 3-hydroxyisovaleric acid in urine from marginally biotin-deficient humans by UPLC-MS/MS
- Urinary Excretion of 3-Hydroxyisovaleryl Carnitine Is an Early and Sensitive Indicator of Marginal Biotin Deficiency in Humans,
Showing 5 of 7 shared publications
M. Bridget Zimmerman
University of Iowa (US)
6 shared publications
- Randomized Trial of Liberal Versus Restrictive Guidelines for Red Blood Cell Transfusion in Preterm Infants
- Red blood cell (RBC) volume can be independently determined in vivo in humans using RBCs labeled at different densities of biotin
- Red blood cell (RBC) volume can be independently determined in vivo in the sheep using ovine RBCs labeled at different densities of biotin
- Comparison of multiple red cell volume methods performed concurrently in premature infants following allogeneic transfusion
- In premature infants there is no decrease in 24‐hour posttransfusion allogeneic red blood cell recovery after 42 days of storage
Showing 5 of 6 shared publications
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