Alex Lagasse

Researcher

University of Arkansas for Medical Sciences

faculty

12 h-index 88 pubs 548 cited

Research Areas

Receptor Mechanisms and Signaling Diet and metabolism studies RNA and protein synthesis mechanisms Genomics and Phylogenetic Studies Metabolism and Genetic Disorders Birth, Development, and Health Neuroscience and Neuropharmacology Research Maternal and Perinatal Health Interventions

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OverviewAI-generated summary

Alex Lagasse's research investigates the molecular mechanisms underlying pituitary gland function, with a particular focus on how diet and hormonal signaling influence gene expression and cell metabolism. Studies have explored the impact of high-fat diets and oxidative stress on anterior pituitary transcriptomics, examining alterations in cell metabolism. Lagasse's work also delves into the role of RNA-binding proteins, such as Musashi, in controlling the translation of key pituitary messenger RNAs that regulate reproductive cycles and luteinizing hormone secretion. Further investigations examine the effects of leptin receptor signaling ablation and VCD-induced menopause on gonadotrope and somatotrope transcriptomes, revealing estrogen-dependent genes within the GnRH signaling pathway. Collaborations with Gwen V. Childs, Angela K. Odle, Melanie Clair Macnicol, and Angus M. MacNicol have resulted in numerous shared publications. Lagasse's scholarly output includes 18 publications with 60 citations and an h-index of 5.

Metrics

  • h-index: 12
  • Publications: 88
  • Citations: 548

Selected Publications

  • OR13-08 Secretoneurin Modulates Gonadotrope Function Cyclically to Regulate LH Secretion (2025) DOI
  • SAT-001 Impact of VCD-induced Menopause on Gonadotrope Transcriptomics Reveals Estrogen-dependent Genes in the GnRH Signaling Pathway (2025) DOI
  • High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes (2025) DOI
  • Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice (2025) DOI
  • 8572 A 30% Maternal Caloric Restriction Alters Expression of Musashi Targets in the Neonatal and Adult Pituitary Proteomes of FVB Mice (2024) DOI
  • 8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells (2024) DOI
  • The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs (2024) DOI
  • Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain (2024) DOI
  • Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism (2023) DOI
  • FRI289 It Takes A Village: Musashi And Its Associated Proteins In The Adenohypophysis (2023) DOI
  • FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes (2023) DOI
  • OR20-03 Leptin-mediated Regulation Of Gene Regulatory Networks In Gonadotropes (2023) DOI
  • THU043 Single-cell Transcriptomics Show Sex-specific Responses To A High Fat Diet, Under Thermoneutral Conditions, Pointing To Reduced Pituitary Plasticity (2023) DOI
  • Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle (2023) DOI
  • 410 Mild Maternal Undernutrition Results in a Premature Neonatal Leptin Surge and Resistance in Male Offspring to a High Fat Diet (2022) DOI

Collaborators

Researchers in the database who share publications

Gwen V. Childs University of Arkansas for Medical Sciences 13 shared publications Angela K. Odle University of Arkansas for Medical Sciences 13 shared publications Melanie Clair Macnicol University of Arkansas for Medical Sciences 13 shared publications Angus M. MacNicol University of Arkansas for Medical Sciences 13 shared publications Anessa Haney University of Arkansas for Medical Sciences 11 shared publications Tiffany K. Miles University of Arkansas for Medical Sciences 10 shared publications Ashley Herdman University of Arkansas for Medical Sciences 8 shared publications Allen Gies University of Arkansas for Medical Sciences 3 shared publications

Similar Researchers

Based on overlapping research topics

Anessa Haney University of Arkansas for Medical Sciences
Receptor Mechanisms and Signaling Diet and metabolism studies RNA and protein synthesis mechanisms
Strong match 7 shared topics
Angus Macnicol University of Arkansas for Medical Sciences
Diet and metabolism studies RNA and protein synthesis mechanisms Metabolism and Genetic Disorders
Good match 5 shared topics
Ashley Herdman University of Arkansas for Medical Sciences
Receptor Mechanisms and Signaling Diet and metabolism studies Genomics and Phylogenetic Studies
Good match 5 shared topics
Tiffany K. Miles University of Arkansas for Medical Sciences
Receptor Mechanisms and Signaling Diet and metabolism studies Genomics and Phylogenetic Studies
Good match 5 shared topics
Milla M Reddick University of Arkansas for Medical Sciences
Diet and metabolism studies RNA and protein synthesis mechanisms Genomics and Phylogenetic Studies
Good match 4 shared topics
Melanie Clair Macnicol University of Arkansas for Medical Sciences
Diet and metabolism studies RNA and protein synthesis mechanisms Metabolism and Genetic Disorders
Good match 4 shared topics