Arny A. Ferrando
Professor
Also affiliated: U.S. Army Research Institute of Environmental Medicine (2016); National Institutes of Health (1998); Universities Space Research Association (2006); Florida Institute for Human and Machine Cognition (2024–2026); The University of Texas MD Anderson Cancer Center (2024); University of Connecticut (2006–2009); Baylor College of Medicine (2006); Inha University (2006); University of Arkansas Medical Center (2010–2025); University of Arkansas System (2010); Shriners Hospitals for Children - Galveston (1995–2009); Hospital General Universitario Gregorio Marañón (2002); Central Arkansas Veterans Healthcare System (2008); Shriners Hospitals for Children - Boston (2008); National Aeronautics and Space Administration (1995–1996); Institute on Aging (2025); Shriners Hospitals for Children (2001–2004); Ajinomoto (Japan) (2006); Hospital Universitari Sant Joan de Reus (2022); Johnson Space Center (1993–2006); Inha University Hospital (2006); National Cattlemen's Beef Association (2009); University of New Mexico Health Sciences Center (2005); The University of Texas Medical Branch at Galveston (1995–2009); Universitat Rovira i Virgili (2022); Auburn University (2021); University of Genoa (2023)
Geriatrics, College of Medicine
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Arny A. Ferrando's research focuses on human skeletal muscle physiology, particularly in the context of aging, bed rest, and nutritional interventions. He has investigated the impact of prolonged bed rest on skeletal muscle and whole-body protein synthesis, as well as the functional consequences of such inactivity in healthy older adults. His work also explores the role of testosterone administration in improving muscle strength and protein synthesis in elderly men, examining the underlying molecular and physiological mechanisms.
Ferrando's research group has also examined the effects of essential amino acid supplementation on postexercise net protein synthesis in human muscle. His publications include work on the persistence of muscle catabolism following severe burns and the relationship between protein and exercise, as reflected in his contributions to the International Society of Sports Nutrition Position Stand. He is a highly cited researcher with an h-index of 60 and over 15,000 citations across more than 465 publications. Key collaborators include David N. Church, Robert R. Wolfe, and Scott Schutzler, all from the University of Arkansas for Medical Sciences.
Metrics
- h-index: 60
- Publications: 466
- Citations: 15,377
Positions
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Professor 2006–presentUniversity of Arkansas for Medical Sciences Geriatrics, College of Medicine Institutional directory
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Director 2016–2024University of Arkansas for Medical Sciences Geriatrics, Center for Translational Research in Aging and Longevity (CTRAL) ORCID
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Professor 2002–2006The University of Texas Medical Branch at Galveston Surgery ORCID
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Lieutenant Colonel; retired 1985–2003United States Army Reserve ORCID
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Associate Professor 1997–2002The University of Texas Medical Branch at Galveston Surgery ORCID
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Assistant Professor 1994–1997The University of Texas Medical Branch at Galveston Surgery ORCID
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NRC Resident Research Associate 1992–1994Johnson Space Center NASA ORCID
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Graduate Teaching Assistant 1989–1991University of the State of Florida ORCID
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Aviation; Pilot 1980–1984United States Army Active Duty ORCID
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Armor Officer 1978–1980United States Army Active Duty ORCID
Selected Publications
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Whole-Body Protein Balance during Arctic Military Training Is Unaffected by Dietary Essential Amino Acid or Energy Density (2026)
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Elevated miR-194-5p Expression during Short-Term Energy Deficit Attenuates Postexercise Muscle Protein Synthesis by Inhibiting Anabolic Signaling (2026)
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Effects of acute essential amino acid intake on post-prandial raw bioimpedance and fluid shifts between healthy young and older adults: An exploratory pilot study (2025)
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The Effects of Essential Amino Acid Supplementation on Hippocampal Neurotrophin, Dopaminergic and Serotonergic Changes in an Overtraining Mouse Model (2025)
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Understanding Dietary Protein Quality: Digestible Indispensable Amino Acid Scores and Beyond (2025)
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Exercise Heart Rate Variability Suggests Parasympathetic Hyperactivity during Simulated Military Operations Irrespective of Testosterone Administration (2025)
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Carbohydrate supplementation maintains physical performance during short-term energy deficit despite reductions in exogenous glucose oxidation (2025)
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Effect of 3 Different Daily Protein Intakes in a 2-Meal Eating Pattern on Protein Turnover in Middle Age and Older Adults: A Randomized Controlled Trial (2024)
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Consideration of the role of protein quality in determining dietary protein recommendations (2024)
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The anabolic response to a ground beef patty and soy-based meat alternative: a randomized controlled trial (2024)
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Consuming Whey Protein with Added Essential Amino Acids, Not Carbohydrate, Maintains Postexercise Anabolism While Underfed (2024)
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Healthy Older Adults Consuming the Protein RDA Show Similar Whole-Body Protein Kinetics While Consuming Vegan and Lacto-Vegetarian Diets (2024)
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Common questions and misconceptions about protein supplementation: what does the scientific evidence really show? (2024)
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440 Muscle Protein Synthesis and Whole-Body Protein Balance Following Ingestion of Beef or a Soy Protein Based Meat Alternative (2024)
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Stimulation of muscle protein synthesis with low-dose amino acid composition in older individuals (2024)
Grants & Funding
As listed on this researcher's institutional profile.
- Ferrando - Pikes Peak U.S. Army Research Institute of Environmental Medicine via Battelle Memorial Institute Principal Investigator
- Stable Isotope Analytical Core for Studies in Human Metabolism NIH Co-Investigator
- Overcoming TWEAK Signaling to Restore Muscle and Mobility Function after Joint Replacement - Continuation - Continuation NIH/National Institutes of Health via University of Alabama at Birmingham Principal Investigator
- Overcoming TWEAK Signaling to Restore Muscle and Mobility Function after Joint Replacement NIH/National Institutes of Health via University of Alabama at Birmingham Principal Investigator
- FE CTA 6-8-2015 NOVARTIS Pharmaceuticals Corporation Principal Investigator
- Effects of Pro-Stat Immuno-Protein Complex (PS-IPC)Supplementation on Muscle Mass and Function, Inflammatory Markers, and Immune Function in Older Adu Medical Nutrition USA, Inc. Principal Investigator
- Testosterone Effects on Muscle in Burn Injury NIH Principal Investigator
- Ferrando - Warfighter Recovery Nutrition: Optimizing Protein Quantity, Quality, and Combat Ration Delivery Systems U.S. Army Research Institute of Environmental Medicine Principal Investigator
- Ferrando - Optimizing Performance for Soldiers II (OPS II ) Pennington/USARIEM U.S. Army Research Institute of Environmental Medicine via Pennington Biomedical Research Center Principal Investigator
- Nutritional Countermeasures to Ameliorate Losses in Muscle Mass and Function National Space Biomedical Research Institute via Baylor College of Medicine Principal Investigator
- Ferrando: Effect of Dietary Protein Intake Pattern on Skeletal Muscle in Older Individuals National Dairy Council Principal Investigator
- Ferrando - Dairy Macronutrient Effects on the Metabolic System The Dairy Research Institute Principal Investigator
- Glucocorticoid antagonism in burned children / Project 2 NIH/Nat. Inst. of General Medical Sciences via University of Texas Medical Branch Principal Investigator
- Protein Kinetic Response to Calorie Deprivation: U.S. Army Research Institute of Environmental Medicine Principal Investigator
- Restoration of Muscle Following Hip Surgery NIH Principal Investigator
- Ferrando - AURIC Year 2 Auburn University Principal Investigator
- Arkansas Claude Pepper Older Americans Independence Center at UAMS NIH Co-Investigator
- Ferrando - D.E.B. Dairy - Effect of Dietary Protein Intake Distribution on Protein Metabolism and Skeletal Muscle National Dairy Council Principal Investigator
- Substrate Cycling in Energy Metabolism NIH Co-Investigator
- Ferrando - Altitude wUSARIEM - The mechanistic effects of acute hypobaric hypoxia on exogenous cargohydrate utilization during steady-state aerobic exercise US Department of the Army Principal Investigator
Collaboration Network
Top Collaborators
- Functional Impact of 10 Days of Bed Rest in Healthy Older Adults
- EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly
- Muscle protein synthesis in cancer patients can be stimulated with a specially formulated medical food
- Acute Energy Deprivation Affects Skeletal Muscle Protein Synthesis and Associated Intracellular Signaling Proteins in Physically Active Adults
- Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding
Showing 5 of 48 shared publications
- Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding
- Muscle Protein Synthesis and Whole-Body Protein Turnover Responses to Ingesting Essential Amino Acids, Intact Protein, and Protein-Containing Mixed Meals with Considerations for Energy Deficit
- International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance
- The contributory role of vascular health in age‐related anabolic resistance
- Anabolic response to essential amino acid plus whey protein composition is greater than whey protein alone in young healthy adults
Showing 5 of 32 shared publications
- Acute Energy Deprivation Affects Skeletal Muscle Protein Synthesis and Associated Intracellular Signaling Proteins in Physically Active Adults
- Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding
- Muscle Protein Synthesis and Whole-Body Protein Turnover Responses to Ingesting Essential Amino Acids, Intact Protein, and Protein-Containing Mixed Meals with Considerations for Energy Deficit
- International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance
- Supplementing an energy adequate, higher protein diet with protein does not enhance fat-free mass restoration after short-term severe negative energy balance
Showing 5 of 23 shared publications
- Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding
- The anabolic response to a meal containing different amounts of protein is not limited by the maximal stimulation of protein synthesis in healthy young adults
- Protein intake distribution pattern does not affect anabolic response, lean body mass, muscle strength or function over 8 weeks in older adults: A randomized-controlled trial
- Severe negative energy balance during 21 d at high altitude decreases fat‐free mass regardless of dietary protein intake: a randomized controlled trial
- Quality of meal protein determines anabolic response in older adults
Showing 5 of 18 shared publications
- Muscle protein synthesis in cancer patients can be stimulated with a specially formulated medical food
- The anabolic response to a meal containing different amounts of protein is not limited by the maximal stimulation of protein synthesis in healthy young adults
- Protein intake distribution pattern does not affect anabolic response, lean body mass, muscle strength or function over 8 weeks in older adults: A randomized-controlled trial
- Quality of meal protein determines anabolic response in older adults
- Anabolic response to essential amino acid plus whey protein composition is greater than whey protein alone in young healthy adults
Showing 5 of 17 shared publications
- Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding
- Home-Based Physical Activity and Diet Intervention to Improve Physical Function in Advanced Liver Disease: A Randomized Pilot Trial
- Anabolic response to essential amino acid plus whey protein composition is greater than whey protein alone in young healthy adults
- Metabolic Evaluation of the Dietary Guidelines’ Ounce Equivalents of Protein Food Sources in Young Adults: A Randomized Controlled Trial
- Quantifying the contribution of dietary protein to whole body protein kinetics: examination of the intrinsically labeled proteins method
Showing 5 of 15 shared publications
- The anabolic response to a meal containing different amounts of protein is not limited by the maximal stimulation of protein synthesis in healthy young adults
- Protein intake distribution pattern does not affect anabolic response, lean body mass, muscle strength or function over 8 weeks in older adults: A randomized-controlled trial
- Quality of meal protein determines anabolic response in older adults
- Anabolic response to essential amino acid plus whey protein composition is greater than whey protein alone in young healthy adults
- Metabolic Evaluation of the Dietary Guidelines’ Ounce Equivalents of Protein Food Sources in Young Adults: A Randomized Controlled Trial
Showing 5 of 14 shared publications
- Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding
- Pre- and Post-Surgical Nutrition for Preservation of Muscle Mass, Strength, and Functionality Following Orthopedic Surgery
- International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance
- High‐intensity interval training and essential amino acid supplementation: Effects on muscle characteristics and whole‐body protein turnover
- Comparison of basal whole‐body protein kinetics and muscle protein synthesis between young and older adults
Showing 5 of 12 shared publications
- Effects of high versus standard essential amino acid intakes on whole-body protein turnover and mixed muscle protein synthesis during energy deficit: A randomized, crossover study
- Essential amino acid-enriched whey enhances post-exercise whole-body protein balance during energy deficit more than iso-nitrogenous whey or a mixed-macronutrient meal: a randomized, crossover study
- Severe energy deficit at high altitude inhibits skeletal muscle mTORC1‐mediated anabolic signaling without increased ubiquitin proteasome activity
- Acute hypoxia reduces exogenous glucose oxidation, glucose turnover, and metabolic clearance rate during steady-state aerobic exercise
- Muscle Fn14 gene expression is associated with fat‐free mass retention during energy deficit at high altitude
Showing 5 of 10 shared publications
- Effects of high versus standard essential amino acid intakes on whole-body protein turnover and mixed muscle protein synthesis during energy deficit: A randomized, crossover study
- Essential amino acid-enriched whey enhances post-exercise whole-body protein balance during energy deficit more than iso-nitrogenous whey or a mixed-macronutrient meal: a randomized, crossover study
- Severe energy deficit at high altitude inhibits skeletal muscle mTORC1‐mediated anabolic signaling without increased ubiquitin proteasome activity
- Acute hypoxia reduces exogenous glucose oxidation, glucose turnover, and metabolic clearance rate during steady-state aerobic exercise
- Muscle Fn14 gene expression is associated with fat‐free mass retention during energy deficit at high altitude
Showing 5 of 10 shared publications
- Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding
- Muscle Protein Synthesis and Whole-Body Protein Turnover Responses to Ingesting Essential Amino Acids, Intact Protein, and Protein-Containing Mixed Meals with Considerations for Energy Deficit
- Mitigation of Muscle Loss in Stressed Physiology: Military Relevance
- Effects of high versus standard essential amino acid intakes on whole-body protein turnover and mixed muscle protein synthesis during energy deficit: A randomized, crossover study
- Essential amino acid-enriched whey enhances post-exercise whole-body protein balance during energy deficit more than iso-nitrogenous whey or a mixed-macronutrient meal: a randomized, crossover study
Showing 5 of 10 shared publications
- Effects of high versus standard essential amino acid intakes on whole-body protein turnover and mixed muscle protein synthesis during energy deficit: A randomized, crossover study
- Metabolomic profiles are reflective of hypoxia-induced insulin resistance during exercise in healthy young adult males
- Muscle Fn14 gene expression is associated with fat‐free mass retention during energy deficit at high altitude
- Testosterone undecanoate administration prevents declines in fat-free mass but not physical performance during simulated multi-stressor military operations
- Effects of testosterone undecanoate on performance during multi-stressor military operations: A trial protocol for the Optimizing Performance for Soldiers II study
Showing 5 of 8 shared publications
- Essential amino acid-enriched whey enhances post-exercise whole-body protein balance during energy deficit more than iso-nitrogenous whey or a mixed-macronutrient meal: a randomized, crossover study
- Consuming Whey Protein with Added Essential Amino Acids, Not Carbohydrate, Maintains Postexercise Anabolism While Underfed
- Testosterone undecanoate administration prevents declines in fat-free mass but not physical performance during simulated multi-stressor military operations
- Effects of testosterone undecanoate on performance during multi-stressor military operations: A trial protocol for the Optimizing Performance for Soldiers II study
- Bioelectrical impedance phase angle is associated with physical performance before but not after simulated multi‐stressor military operations
Showing 5 of 8 shared publications
- Acute Energy Deprivation Affects Skeletal Muscle Protein Synthesis and Associated Intracellular Signaling Proteins in Physically Active Adults
- Severe negative energy balance during 21 d at high altitude decreases fat‐free mass regardless of dietary protein intake: a randomized controlled trial
- Effects of high versus standard essential amino acid intakes on whole-body protein turnover and mixed muscle protein synthesis during energy deficit: A randomized, crossover study
- Essential amino acid-enriched whey enhances post-exercise whole-body protein balance during energy deficit more than iso-nitrogenous whey or a mixed-macronutrient meal: a randomized, crossover study
- Severe energy deficit at high altitude inhibits skeletal muscle mTORC1‐mediated anabolic signaling without increased ubiquitin proteasome activity
Showing 5 of 7 shared publications
- Translational signaling responses preceding resistance training-mediated myofiber hypertrophy in young and old humans
- Muscle inflammation susceptibility: a prognostic index of recovery potential after hip arthroplasty?
- Perioperative assessment of muscle inflammation susceptibility in patients with end-stage osteoarthritis
- Osteoarthritis Progression: Mitigation and Rehabilitation Strategies
- Muscle Fn14 gene expression is associated with fat‐free mass retention during energy deficit at high altitude
Showing 5 of 7 shared publications
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