Robert R. Wolfe
High Impact
Professor
University of Arkansas for Medical Sciences
faculty
Geriatrics, College of Medicine
132 h-index
1054 pubs
64,162 cited
Research Areas
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Biography and Research Information
OverviewAI-generated summary
Robert R. Wolfe is a Professor in Geriatrics at the University of Arkansas for Medical Sciences. His research focuses on the role of nutrition, metabolism, and exercise in preserving muscle mass, strength, and function, particularly in older adults and following orthopedic surgery. Wolfe has investigated the effects of essential amino acid supplementation and specially formulated dietary supplements on physical performance in older adults with low physical functioning. His work also explores metabolic pathways, including the Warburg, Cori-cycle, and Crabtree effects, and their implications in health and disease, such as in liver cancer.
Wolfe's scholarship is extensive, with a h-index of 132 and over 1054 publications, accumulating more than 64,000 citations. He is recognized as a highly cited researcher. He actively collaborates with colleagues at the University of Arkansas for Medical Sciences, including Arny A. Ferrando, David D. Church, Gohar M. Azhar, and Elisabet Børsheim, with whom he has co-authored numerous publications. He leads a research group and maintains an active lab website.
Metrics
- h-index: 132
- Publications: 1054
- Citations: 64,162
Selected Publications
- Understanding Dietary Protein Quality: Digestible Indispensable Amino Acid Scores and Beyond (2025) DOI
- Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure With Preserved Ejection Fraction (2025) DOI
- A new concept to establish protein requirements (2025) DOI
- Effect of 3 Different Daily Protein Intakes in a 2-Meal Eating Pattern on Protein Turnover in Middle Age and Older Adults: A Randomized Controlled Trial (2024) DOI
- Consideration of the role of protein quality in determining dietary protein recommendations (2024) DOI
- Toward a Dynamic Model of Indispensable Amino Acid Requirements of the Adult Human: A Factorial Estimate of Oxidative Amino Acid Losses (2024) DOI
- The anabolic response to a ground beef patty and soy-based meat alternative: a randomized controlled trial (2024) DOI
- Consuming Whey Protein with Added Essential Amino Acids, Not Carbohydrate, Maintains Postexercise Anabolism While Underfed (2024) DOI
- Free essential amino acid feeding improves endurance during resistance training via DRP1‐dependent mitochondrial remodelling (2024) DOI
- Inhibitory Regulation of FOXO1 in PPARδ Expression Drives Mitochondrial Dysfunction and Insulin Resistance (2024) DOI
- Stimulation of muscle protein synthesis with low-dose amino acid composition in older individuals (2024) DOI
- Metabolic effects of an essential amino acid supplement in adolescents with <scp>PCOS</scp> and obesity (2024) DOI
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome (2024) DOI
- The Importance of Dietary Protein Quality in Mid- to High-Income Countries (2024) DOI
- International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance (2023) DOI
Grants & Funding
- Nutritional Countermeasures to Ameliorate Losses in Muscle Mass and Function National Space Biomedical Research Institute - Pass Through: Baylor College of Medicine Principal Investigator
- Ferrando: Effect of Dietary Protein Intake Pattern on Skeletal Muscle in Older Individuals National Dairy Council Co-Investigator
- EXERCISE EFFECTS ON PROTEIN METABOLISM NIH Principal Investigator
- Wolfe SubK-Vanderbilt Tracer Course 2018 - Continuation NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases - Pass Through: Vanderbilt University Principal Investigator
- Wolfe-KIWI Sub w/Massey: Speeding Up a Slow Protein for Muscle Mass with Hayward Kiwi fruit Zespri Group Limited - Pass Through: Massey University Principal Investigator
- PROTOCOL #2: The Effect of Frequent EAA Ingestion on Resting Energy Expenditure and 24hr Muscle Protein Synthesis NOVARTIS Pharmaceuticals Corporation Principal Investigator
- RES-DZ-01-03 Study in Septic-shock ICU Patients in Which Arginine was Infused to Improve Their Condition-Nicolaas Deitz, Co-I NOVARTIS Pharmaceuticals Corporation Principal Investigator
- Protein Kinetic Response to Calorie Deprivation: U.S. Army Research Institute of Environmental Medicine Principal Investigator
Collaboration Network
Top Collaborators
Arny A. Ferrando
Institute on Aging
14 shared publications
In database
- Pre- and Post-Surgical Nutrition for Preservation of Muscle Mass, Strength, and Functionality Following Orthopedic Surgery
- International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- Essential amino acid-enriched whey enhances post-exercise whole-body protein balance during energy deficit more than iso-nitrogenous whey or a mixed-macronutrient meal: a randomized, crossover study
- Tracing metabolic flux to assess optimal dietary protein and amino acid consumption
Showing 5 of 14 shared publications
David D. Church
Institute on Aging (US)
12 shared publications
- International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance
- Essential amino acid-enriched whey enhances post-exercise whole-body protein balance during energy deficit more than iso-nitrogenous whey or a mixed-macronutrient meal: a randomized, crossover study
- Consideration of the role of protein quality in determining dietary protein recommendations
- Whole-body protein kinetic models to quantify the anabolic response to dietary protein consumption
- The anabolic response to a ground beef patty and soy-based meat alternative: a randomized controlled trial
Showing 5 of 12 shared publications
Sanghee Park
Gachon University (KR)
11 shared publications
- Mitoribosomal defects aggravate liver cancer via aberrant glycolytic flux and T cell exhaustion
- Myostatin Inhibition-Induced Increase in Muscle Mass and Strength Was Amplified by Resistance Exercise Training, and Dietary Essential Amino Acids Improved Muscle Quality in Mice
- Tracing metabolic flux in vivo: basic model structures of tracer methodology
- Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice
- Tracing metabolic flux to assess optimal dietary protein and amino acid consumption
Showing 5 of 11 shared publications
Il‐Young Kim
Gachon University (KR)
11 shared publications
- Mitoribosomal defects aggravate liver cancer via aberrant glycolytic flux and T cell exhaustion
- Myostatin Inhibition-Induced Increase in Muscle Mass and Strength Was Amplified by Resistance Exercise Training, and Dietary Essential Amino Acids Improved Muscle Quality in Mice
- Tracing metabolic flux in vivo: basic model structures of tracer methodology
- Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice
- Tracing metabolic flux to assess optimal dietary protein and amino acid consumption
Showing 5 of 11 shared publications
Yeongmin Kim
Gachon University (KR)
7 shared publications
- Mitoribosomal defects aggravate liver cancer via aberrant glycolytic flux and T cell exhaustion
- Myostatin Inhibition-Induced Increase in Muscle Mass and Strength Was Amplified by Resistance Exercise Training, and Dietary Essential Amino Acids Improved Muscle Quality in Mice
- Tracing metabolic flux in vivo: basic model structures of tracer methodology
- Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice
- Balanced Free Essential Amino Acids and Resistance Exercise Training Synergistically Improve Dexamethasone-Induced Impairments in Muscle Strength, Endurance, and Insulin Sensitivity in Mice
Showing 5 of 7 shared publications
Gohar Azhar
Institute on Aging
6 shared publications
In database
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- The anabolic response to a ground beef patty and soy-based meat alternative: a randomized controlled trial
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
Showing 5 of 6 shared publications
Paul J. Moughan
Riddet Institute (NZ)
5 shared publications
- The Importance of Dietary Protein Quality in Mid- to High-Income Countries
- Consideration of the role of protein quality in determining dietary protein recommendations
- Whole-body protein kinetic models to quantify the anabolic response to dietary protein consumption
- Understanding Dietary Protein Quality: Digestible Indispensable Amino Acid Scores and Beyond
- Toward a Dynamic Model of Indispensable Amino Acid Requirements of the Adult Human: A Factorial Estimate of Oxidative Amino Acid Losses
Katie R. Hirsch
University of Arkansas for Medical Sciences (US)
5 shared publications
- Pre- and Post-Surgical Nutrition for Preservation of Muscle Mass, Strength, and Functionality Following Orthopedic Surgery
- International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance
- The anabolic response to a ground beef patty and soy-based meat alternative: a randomized controlled trial
- Continuous oral stable isotope ingestion to measure whole-body protein turnover
- Effect of 3 Different Daily Protein Intakes in a 2-Meal Eating Pattern on Protein Turnover in Middle Age and Older Adults: A Randomized Controlled Trial
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