Clark Sims
Assistant Staff Scientist
staff
Pediatrics, College of Medicine
Research Areas
Biography and Research Information
OverviewAI-generated summary
Clark Sims' research focuses on maternal and infant health, particularly the interplay between maternal body composition, diet, and offspring development. His work investigates how maternal overweight and obesity influence human milk composition, including oligosaccharides and branched-chain amino acids, and how these factors predict infant growth. Sims also studies the associations between maternal diet, body composition, and the gut microbial ecology during pregnancy, as well as the impact of maternal obesity on the offspring's gut microbiome in the first year of life. His research further explores the long-term skeletal development of infants fed different types of milk and how breastfeeding duration modifies the relationship between maternal weight status and offspring metabolic outcomes. Additionally, he has investigated the association between per- and polyfluoroalkyl substances (PFAS) exposure during pregnancy and maternal cardiometabolic health.
Metrics
- h-index: 15
- Publications: 63
- Citations: 777
Selected Publications
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Circulating short- and medium-chain fatty acids in pregnancy and associations with maternal and infant metabolism, inflammation, and body composition (2026)
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Characterizing Human Milk RNA Degradation Over Time to Optimize Storage of Human Milk for RNA Quality (2026)
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Promoting Breastfeeding Among Latina Women in a Community Pediatric Clinic (2025)
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The Effect of an Exercise Program on Maternal Health and Birth Outcomes in Sedentary Pregnant Participants with Obesity: Randomized Controlled Trial (2025)
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Sex-Dependent Relationships Between PFAS and Placental Transcriptomics Identified by Weighted Gene Co-Expression Analysis (2025)
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Individual and mixture associations of placental per- and polyfluoroalkyl substance with neurodevelopment at 12 and 24 months of age (2025)
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Prenatal Polyphenol Intake During Late Pregnancy Is Positively Associated With Academic and IQ Scores in School-Age Children (2025)
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Breastfeeding beyond infancy supports adequate growth, development, and nutritional intake (2025)
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Individual and mixtures of PFAS during pregnancy are associated with maternal cardiometabolic outcomes during pregnancy (2025)
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Dietary modulation of human milk bioactives is associated with maternal FUT2 secretor phenotype: an exploratory analysis of carotenoids and polyphenol metabolites (2024)
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Exploring the relationship between child temperament, maternal psychiatric symptoms, family environment and infant feeding (2024)
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Maternal immune cell gene expression associates with maternal gut microbiome, milk composition and infant gut microbiome (2024)
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Childhood cardiometabolic risk factors associated with the perinatal environment of the maternal–paternal–child triad (2024)
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PFAS exposures during pregnancy are associated with infant growth and development during the first 2 years of life (2024)
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PFAS exposure during pregnancy is associated with maternal cardiometabolic and birth outcomes (2024)
Grants & Funding
- Renal microcirculatory failure in a rat pup model of pediatric sepsis American Heart Association (SouthWest Affiliate) Principal Investigator
- Targeting renal perfusion and mitochondrial oxidants in a model of infant sepsis NIH Principal Investigator
Collaboration Network
Top Collaborators
- Human Milk Oligosaccharide Concentrations and Infant Intakes Are Associated with Maternal Overweight and Obesity and Predict Infant Growth
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Infant intakes of human milk branched chain amino acids are negatively associated with infant growth and influenced by maternal body mass index
- A Mediterranean diet plan in lactating women with obesity reduces maternal energy intake and modulates human milk composition – a feasibility study
Showing 5 of 35 shared publications
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- A Mediterranean diet plan in lactating women with obesity reduces maternal energy intake and modulates human milk composition – a feasibility study
- Individual and mixtures of PFAS during pregnancy are associated with maternal cardiometabolic outcomes during pregnancy
- Alterations in the Gut Microbiome of Infants Consuming Partially Hydrolyzed Cow Milk Protein Formula
Showing 5 of 13 shared publications
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Individual and mixtures of PFAS during pregnancy are associated with maternal cardiometabolic outcomes during pregnancy
- Alterations in the Gut Microbiome of Infants Consuming Partially Hydrolyzed Cow Milk Protein Formula
- Maternal immune cell gene expression associates with maternal gut microbiome, milk composition and infant gut microbiome
Showing 5 of 12 shared publications
- A Mediterranean diet plan in lactating women with obesity reduces maternal energy intake and modulates human milk composition – a feasibility study
- Dietary modulation of human milk bioactives is associated with maternal FUT2 secretor phenotype: an exploratory analysis of carotenoids and polyphenol metabolites
- Effect of a dietary and exercise intervention in women with overweight and obesity undergoing fertility treatments: protocol for a randomized controlled trial
- Associations Between Maternal Physical Activity, Maternal Lipid Levels, and Infant Anthropometric Outcomes at Two Weeks of Age
- Breastfeeding beyond infancy supports adequate growth, development, and nutritional intake
Showing 5 of 10 shared publications
- A Mediterranean diet plan in lactating women with obesity reduces maternal energy intake and modulates human milk composition – a feasibility study
- Associations Between Maternal Physical Activity, Maternal Lipid Levels, and Infant Anthropometric Outcomes at Two Weeks of Age
- Childhood cardiometabolic risk factors associated with the perinatal environment of the maternal–paternal–child triad
- Breastfeeding beyond infancy supports adequate growth, development, and nutritional intake
- The Impact of Excessive Weight on Breastfeeding Intention, Initiation, and Duration
Showing 5 of 9 shared publications
- A Mediterranean diet plan in lactating women with obesity reduces maternal energy intake and modulates human milk composition – a feasibility study
- Dietary modulation of human milk bioactives is associated with maternal FUT2 secretor phenotype: an exploratory analysis of carotenoids and polyphenol metabolites
- Effect of a dietary and exercise intervention in women with overweight and obesity undergoing fertility treatments: protocol for a randomized controlled trial
- A Mediterranean Meal Plan Modulates Human Milk Composition in Women With Obesity
- A Mediterranean Meal Plan Modulates Fatty Acid Content of Human Milk in Women With Obesity
Showing 5 of 8 shared publications
- Infant intakes of human milk branched chain amino acids are negatively associated with infant growth and influenced by maternal body mass index
- Breastfeeding duration modifies the association between maternal weight status and offspring dietary palmitate oxidation
- Effect of a dietary and exercise intervention in women with overweight and obesity undergoing fertility treatments: protocol for a randomized controlled trial
- Childhood cardiometabolic risk factors associated with the perinatal environment of the maternal–paternal–child triad
- Excessive Gestational Weight Gain, Independent of Body Mass Index, Is Associated With Child Fat Mass Index at Age 2 Years in the Growing life, Optimizing Wellness Study
Showing 5 of 7 shared publications
- Individual and mixtures of PFAS during pregnancy are associated with maternal cardiometabolic outcomes during pregnancy
- Pfas Exposure During Pregnancy is Associated with Maternal Cardiometabolic and Birth Outcomes
- PFAS exposure during pregnancy is associated with maternal cardiometabolic and birth outcomes
- PFAS exposures during pregnancy are associated with infant growth and development during the first 2 years of life
- Individual and mixture associations of placental per- and polyfluoroalkyl substance with neurodevelopment at 12 and 24 months of age
Showing 5 of 7 shared publications
- Human Milk Oligosaccharide Concentrations and Infant Intakes Are Associated with Maternal Overweight and Obesity and Predict Infant Growth
- Infant intakes of human milk branched chain amino acids are negatively associated with infant growth and influenced by maternal body mass index
- A Mediterranean diet plan in lactating women with obesity reduces maternal energy intake and modulates human milk composition – a feasibility study
- Childhood cardiometabolic risk factors associated with the perinatal environment of the maternal–paternal–child triad
- Infant Intakes of Human Milk Amino Acids Are Associated With Maternal Obesity and Infant Growth
Showing 5 of 6 shared publications
- Human Milk Oligosaccharide Concentrations and Infant Intakes Are Associated with Maternal Overweight and Obesity and Predict Infant Growth
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- A Mediterranean diet plan in lactating women with obesity reduces maternal energy intake and modulates human milk composition – a feasibility study
- Dietary modulation of human milk bioactives is associated with maternal FUT2 secretor phenotype: an exploratory analysis of carotenoids and polyphenol metabolites
- Maternal immune cell gene expression associates with maternal gut microbiome, milk composition and infant gut microbiome
Showing 5 of 6 shared publications
- Individual and mixtures of PFAS during pregnancy are associated with maternal cardiometabolic outcomes during pregnancy
- A Mediterranean Meal Plan Modulates Fatty Acid Content of Human Milk in Women With Obesity
- Pfas Exposure During Pregnancy is Associated with Maternal Cardiometabolic and Birth Outcomes
- PFAS exposure during pregnancy is associated with maternal cardiometabolic and birth outcomes
- PFAS exposures during pregnancy are associated with infant growth and development during the first 2 years of life
Showing 5 of 6 shared publications
- Individual and mixtures of PFAS during pregnancy are associated with maternal cardiometabolic outcomes during pregnancy
- Pfas Exposure During Pregnancy is Associated with Maternal Cardiometabolic and Birth Outcomes
- PFAS exposures during pregnancy are associated with infant growth and development during the first 2 years of life
- Individual and mixture associations of placental per- and polyfluoroalkyl substance with neurodevelopment at 12 and 24 months of age
- Sex-Dependent Relationships Between PFAS and Placental Transcriptomics Identified by Weighted Gene Co-Expression Analysis
Showing 5 of 6 shared publications
- Breastfeeding duration modifies the association between maternal weight status and offspring dietary palmitate oxidation
- Dietary modulation of human milk bioactives is associated with maternal FUT2 secretor phenotype: an exploratory analysis of carotenoids and polyphenol metabolites
- Childhood cardiometabolic risk factors associated with the perinatal environment of the maternal–paternal–child triad
- Breastfeeding beyond infancy supports adequate growth, development, and nutritional intake
- Promoting Breastfeeding Among Latina Women in a Community Pediatric Clinic
- Childhood cardiometabolic risk factors associated with the perinatal environment of the maternal–paternal–child triad
- Healthful Eating Behaviors among Couples Contribute to Lower Gestational Weight Gain
- Excessive Gestational Weight Gain, Independent of Body Mass Index, Is Associated With Child Fat Mass Index at Age 2 Years in the Growing life, Optimizing Wellness Study
- P18-057-23 In Couples With Obesity, Poor Paternal Tendency To Eat in Response to Food Cues and Limit Food Intake Is Associated With Higher Total and Rate of Maternal Gestational Weight Gain
- OR21-03-23 Associations Between Prenatal and Postnatal Factors and Child Adiposity at 5 Years of Age in a Longitudinal, Observational Cohort
- Individual and mixtures of PFAS during pregnancy are associated with maternal cardiometabolic outcomes during pregnancy
- Pfas Exposure During Pregnancy is Associated with Maternal Cardiometabolic and Birth Outcomes
- PFAS exposure during pregnancy is associated with maternal cardiometabolic and birth outcomes
- PFAS exposures during pregnancy are associated with infant growth and development during the first 2 years of life
- Individual and mixture associations of placental per- and polyfluoroalkyl substance with neurodevelopment at 12 and 24 months of age
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