Clark Sims
Assistant Staff Scientist
Also affiliated: San Francisco General Hospital (1978); SRI International (1978); Arkansas Children's Hospital (2013–2026); San Francisco VA Medical Center (1978); University of Arkansas Medical Center (2024); Ellis Hospital (1978); Surgical Specialties (United States) (1978); Arkansas Children's Nutrition Center (2013–2026)
Staff Researcher
Pediatrics, College of Medicine
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Clark Sims studies the relationship between maternal health, particularly overweight and obesity, and infant development. His research investigates how factors such as maternal diet, body composition, and human milk composition influence infant growth, gut microbiome, and skeletal development. Sims has received funding for projects examining the associations between maternal obesity and offspring gut microbiome in the first year of life, and the impact of maternal diet and body composition on gut microbial ecology during pregnancy. His work also explores the effects of human milk oligosaccharides and branched-chain amino acids on infant growth, and how breastfeeding duration modifies the association between maternal weight status and offspring dietary palmitate oxidation. Sims has also investigated the association between per- and polyfluoroalkyl substances (PFAS) during pregnancy and maternal cardiometabolic outcomes.
Metrics
- h-index: 16
- Publications: 63
- Citations: 819
Selected Publications
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Circulating short- and medium-chain fatty acids in pregnancy and associations with maternal and infant metabolism, inflammation, and body composition (2026)
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Characterizing Human Milk RNA Degradation Over Time to Optimize Storage of Human Milk for RNA Quality (2026)
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Promoting Breastfeeding Among Latina Women in a Community Pediatric Clinic (2025)
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The Effect of an Exercise Program on Maternal Health and Birth Outcomes in Sedentary Pregnant Participants with Obesity: Randomized Controlled Trial (2025)
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Sex-Dependent Relationships Between PFAS and Placental Transcriptomics Identified by Weighted Gene Co-Expression Analysis (2025)
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Individual and mixture associations of placental per- and polyfluoroalkyl substance with neurodevelopment at 12 and 24 months of age (2025)
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Prenatal Polyphenol Intake During Late Pregnancy Is Positively Associated With Academic and IQ Scores in School-Age Children (2025)
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Breastfeeding beyond infancy supports adequate growth, development, and nutritional intake (2025)
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Individual and mixtures of PFAS during pregnancy are associated with maternal cardiometabolic outcomes during pregnancy (2025)
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Dietary modulation of human milk bioactives is associated with maternal FUT2 secretor phenotype: an exploratory analysis of carotenoids and polyphenol metabolites (2024)
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Exploring the relationship between child temperament, maternal psychiatric symptoms, family environment and infant feeding (2024)
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Maternal immune cell gene expression associates with maternal gut microbiome, milk composition and infant gut microbiome (2024)
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Childhood cardiometabolic risk factors associated with the perinatal environment of the maternal–paternal–child triad (2024)
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PFAS exposures during pregnancy are associated with infant growth and development during the first 2 years of life (2024)
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PFAS exposure during pregnancy is associated with maternal cardiometabolic and birth outcomes (2024)
Grants & Funding
As listed on this researcher's institutional profile.
- Renal microcirculatory failure in a rat pup model of pediatric sepsis American Heart Association (SouthWest Affiliate) Principal Investigator
- Targeting renal perfusion and mitochondrial oxidants in a model of infant sepsis NIH Principal Investigator
Collaboration Network
Top Collaborators
- Human Milk Oligosaccharide Concentrations and Infant Intakes Are Associated with Maternal Overweight and Obesity and Predict Infant Growth
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Infant intakes of human milk branched chain amino acids are negatively associated with infant growth and influenced by maternal body mass index
- A Mediterranean diet plan in lactating women with obesity reduces maternal energy intake and modulates human milk composition – a feasibility study
Showing 5 of 27 shared publications
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- A Mediterranean diet plan in lactating women with obesity reduces maternal energy intake and modulates human milk composition – a feasibility study
- Individual and mixtures of PFAS during pregnancy are associated with maternal cardiometabolic outcomes during pregnancy
- Alterations in the Gut Microbiome of Infants Consuming Partially Hydrolyzed Cow Milk Protein Formula
Showing 5 of 11 shared publications
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Individual and mixtures of PFAS during pregnancy are associated with maternal cardiometabolic outcomes during pregnancy
- Maternal immune cell gene expression associates with maternal gut microbiome, milk composition and infant gut microbiome
- Alterations in the Gut Microbiome of Infants Consuming Partially Hydrolyzed Cow Milk Protein Formula
Showing 5 of 10 shared publications
- A Mediterranean diet plan in lactating women with obesity reduces maternal energy intake and modulates human milk composition – a feasibility study
- Dietary modulation of human milk bioactives is associated with maternal FUT2 secretor phenotype: an exploratory analysis of carotenoids and polyphenol metabolites
- Effect of a dietary and exercise intervention in women with overweight and obesity undergoing fertility treatments: protocol for a randomized controlled trial
- Associations Between Maternal Physical Activity, Maternal Lipid Levels, and Infant Anthropometric Outcomes at Two Weeks of Age
- Breastfeeding beyond infancy supports adequate growth, development, and nutritional intake
Showing 5 of 8 shared publications
- A Mediterranean diet plan in lactating women with obesity reduces maternal energy intake and modulates human milk composition – a feasibility study
- Associations Between Maternal Physical Activity, Maternal Lipid Levels, and Infant Anthropometric Outcomes at Two Weeks of Age
- Childhood cardiometabolic risk factors associated with the perinatal environment of the maternal–paternal–child triad
- Breastfeeding beyond infancy supports adequate growth, development, and nutritional intake
- The Impact of Excessive Weight on Breastfeeding Intention, Initiation, and Duration
Showing 5 of 7 shared publications
- Human Milk Oligosaccharide Concentrations and Infant Intakes Are Associated with Maternal Overweight and Obesity and Predict Infant Growth
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- A Mediterranean diet plan in lactating women with obesity reduces maternal energy intake and modulates human milk composition – a feasibility study
- Maternal immune cell gene expression associates with maternal gut microbiome, milk composition and infant gut microbiome
- Dietary modulation of human milk bioactives is associated with maternal FUT2 secretor phenotype: an exploratory analysis of carotenoids and polyphenol metabolites
Showing 5 of 6 shared publications
- A Mediterranean diet plan in lactating women with obesity reduces maternal energy intake and modulates human milk composition – a feasibility study
- Dietary modulation of human milk bioactives is associated with maternal FUT2 secretor phenotype: an exploratory analysis of carotenoids and polyphenol metabolites
- Effect of a dietary and exercise intervention in women with overweight and obesity undergoing fertility treatments: protocol for a randomized controlled trial
- Maternal FUT2 Secretor Phenotype Is Associated With Human Milk Oligosaccharides and Polyphenol Metabolites Following a Mediterranean Dietary Intervention: A Pilot Study
- Associations Between Prenatal Supplementation, Maternal Dietary Intake, and Maternal Metabolic Profiles
Showing 5 of 6 shared publications
- Individual and mixtures of PFAS during pregnancy are associated with maternal cardiometabolic outcomes during pregnancy
- Pfas Exposure During Pregnancy is Associated with Maternal Cardiometabolic and Birth Outcomes
- PFAS exposure during pregnancy is associated with maternal cardiometabolic and birth outcomes
- PFAS exposures during pregnancy are associated with infant growth and development during the first 2 years of life
- Individual and mixture associations of placental per- and polyfluoroalkyl substance with neurodevelopment at 12 and 24 months of age
Showing 5 of 6 shared publications
- Infant intakes of human milk branched chain amino acids are negatively associated with infant growth and influenced by maternal body mass index
- Breastfeeding duration modifies the association between maternal weight status and offspring dietary palmitate oxidation
- Effect of a dietary and exercise intervention in women with overweight and obesity undergoing fertility treatments: protocol for a randomized controlled trial
- Childhood cardiometabolic risk factors associated with the perinatal environment of the maternal–paternal–child triad
- The Effect of an Exercise Program on Maternal Health and Birth Outcomes in Sedentary Pregnant Participants with Obesity: Randomized Controlled Trial
- Breastfeeding duration modifies the association between maternal weight status and offspring dietary palmitate oxidation
- Dietary modulation of human milk bioactives is associated with maternal FUT2 secretor phenotype: an exploratory analysis of carotenoids and polyphenol metabolites
- Childhood cardiometabolic risk factors associated with the perinatal environment of the maternal–paternal–child triad
- Breastfeeding beyond infancy supports adequate growth, development, and nutritional intake
- Promoting Breastfeeding Among Latina Women in a Community Pediatric Clinic
- Individual and mixtures of PFAS during pregnancy are associated with maternal cardiometabolic outcomes during pregnancy
- Pfas Exposure During Pregnancy is Associated with Maternal Cardiometabolic and Birth Outcomes
- PFAS exposure during pregnancy is associated with maternal cardiometabolic and birth outcomes
- PFAS exposures during pregnancy are associated with infant growth and development during the first 2 years of life
- Individual and mixture associations of placental per- and polyfluoroalkyl substance with neurodevelopment at 12 and 24 months of age
- Individual and mixtures of PFAS during pregnancy are associated with maternal cardiometabolic outcomes during pregnancy
- Pfas Exposure During Pregnancy is Associated with Maternal Cardiometabolic and Birth Outcomes
- PFAS exposure during pregnancy is associated with maternal cardiometabolic and birth outcomes
- PFAS exposures during pregnancy are associated with infant growth and development during the first 2 years of life
- Individual and mixture associations of placental per- and polyfluoroalkyl substance with neurodevelopment at 12 and 24 months of age
- Individual and mixtures of PFAS during pregnancy are associated with maternal cardiometabolic outcomes during pregnancy
- Pfas Exposure During Pregnancy is Associated with Maternal Cardiometabolic and Birth Outcomes
- PFAS exposures during pregnancy are associated with infant growth and development during the first 2 years of life
- Individual and mixture associations of placental per- and polyfluoroalkyl substance with neurodevelopment at 12 and 24 months of age
- Sex-Dependent Relationships Between PFAS and Placental Transcriptomics Identified by Weighted Gene Co-Expression Analysis
- Human Milk Oligosaccharide Concentrations and Infant Intakes Are Associated with Maternal Overweight and Obesity and Predict Infant Growth
- Infant intakes of human milk branched chain amino acids are negatively associated with infant growth and influenced by maternal body mass index
- A Mediterranean diet plan in lactating women with obesity reduces maternal energy intake and modulates human milk composition – a feasibility study
- Childhood cardiometabolic risk factors associated with the perinatal environment of the maternal–paternal–child triad
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Maternal immune cell gene expression associates with maternal gut microbiome, milk composition and infant gut microbiome
- Alterations in the Gut Microbiome of Infants Consuming Partially Hydrolyzed Cow Milk Protein Formula
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