Crystal R. Archer

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Federal Grant PI

Assistant Professor of Biochemistry

University of Arkansas

Also affiliated: University of Hawaiʻi at Mānoa (2008–2012); University of Hawaii System (2012); The University of Texas at San Antonio Health Science Center (2013–2024); Armstrong Atlantic State University (2012); Urology San Antonio (2019); Cancer Center of Hawaii (2010–2012); Cancer Research Center (2010); Integrative Health Technologies (United States) (2018–2021); The University of Texas at San Antonio (2019–2024); Technical University of Munich (2008); The University of Texas Health Science Center at Houston (2018–2021)

Faculty Researcher

9 h-index 36 pubs 500 cited

Research Areas

Biomedical Subjects

Links

ORCID Research Group

OverviewAI-generated summary

Crystal R. Archer investigates the molecular mechanisms underlying ion channel regulation, with a particular focus on the epithelial sodium channel (ENaC) and potassium voltage-gated channel subfamily Q member 2 (Kv7.2).

Her research group studies how cellular signaling pathways and protein interactions influence the function of these ion channels. Recent publications explore the roles of casein kinase II, ankyrin-3, P2Y2 receptor, NOXA1-dependent NADPH oxidase 1 signaling, and Gs-coupled designer receptors in modulating ENaC activity. These studies have implications for understanding conditions such as hypertension. Additionally, her work examines the regulation of Kv7.2 channels through phosphorylation, calmodulin, and phosphatidylinositol 4,5-bisphosphate (PIP2) interactions, as evidenced by her NIH-funded project investigating the structural consequences of PKC-dependent phosphorylation of Kv7.2.

Archer also employs and develops biophysical techniques for molecular analysis, including isothermal titration calorimetry for fragment-based studies of ion channel interactions. Her research group comprises collaborators Phuc Phan and Divya Sapkota, both at the University of Arkansas at Fayetteville, with whom she has co-authored publications.

Metrics

h-index: 9
Publications: 36
Citations: 500

Selected Publications

ENaC phosphorylation facilitates ankyrin-3 interaction critical for renal sodium balance (2026)

PNAS Nexus DOI OpenAlex
BPS2026 – Regulation of the KCNQ4 channel via the interplay between phosphorylation, calmodulin, and PIP2 (2026)

Biophysical Journal DOI OpenAlex
Abstract 2279 Phosphorylation control of Kv7.2 structure and interactions in response to GPCR signals (2025)

Journal of Biological Chemistry DOI OpenAlex