Diane Lipscombe Source Confirmed
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Researcher
John Brown University
faculty
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Biography and Research Information
OverviewAI-generated summary
Diane Lipscombe is actively engaged in neuroscience and neuropharmacology research at John Brown University, with a focus on ion channel regulation and function. Her work encompasses investigations into pain mechanisms and potential treatments, as well as RNA research related to splicing. Lipscombe's expertise extends to the study of nicotinic acetylcholine receptors. Recent research includes the analysis of rare missense variants of *CACNA1I* in a Swedish schizophrenia cohort and exploration of all-optical synapses for selective control of synaptically-connected circuit elements. She has also investigated the role of voltage-gated Ca<sub>V</sub>2.2 calcium channel activity in peripheral axon terminals and developed bioluminescent tools for studying neuronal activity, including a high-contrast bioluminescent Ca<sup>2+</sup> indicator and methods for bioluminescent optogenetic activation of neurons during brain development. Her primary research interest lies in ion channel function.
Metrics
- h-index: 37
- Publications: 116
- Citations: 7,383
Selected Publications
- Control of Synaptic Communication through Molecularly Engineered Bioluminescence Light Emission and Sensing (2025) DOI
- <i>Trpv1</i> -dependent <i>Cacna1b</i> gene inactivation reveals cell-specific functions of Ca <sub>V</sub> 2.2 channels <i>in vivo</i> (2025) DOI
- ω-Phonetoxins inhibit voltage-gated calcium Ca <sub>V</sub> 2.2 ion channel splice isoforms of dorsal root ganglia (2023) DOI
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