Donald G. Catanzaro
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Assistant Professor
Also affiliated: California Department of Public Health (2016); San Diego State University (2013–2014); University of California San Diego (2012–2018); San Francisco Department of Public Health (2018); Health and Human Services Agency (2018); San Joaquin County Public Health Services (2018)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Donald G. Catanzaro's research focuses on understanding drug resistance in *Mycobacterium tuberculosis*, the bacterium responsible for tuberculosis. His work has involved systematic reviews to evaluate genetic mutations associated with resistance to key antitubercular agents, including isoniazid, fluoroquinolones, amikacin, kanamycin, and capreomycin. He has investigated the frequency and geographic distribution of specific genetic mutations, such as those in the *gyrA* and *gyrB* genes, which confer resistance to fluoroquinolones.
Catanzaro has also explored methods for detecting drug resistance in *Mycobacterium tuberculosis*. This includes research on amplicon sequencing for rapid drug susceptibility testing directly from clinical samples and the detection of low-level mixed-population drug resistance using high-fidelity sequencing. More recently, his work has extended to the development of CRISPR-based detection of circulating cell-free *Mycobacterium tuberculosis* DNA in both adults and children, including those with HIV.
His scholarship metrics indicate a significant body of work, with an h-index of 22 and over 2,100 citations across approximately 60 publications. He has collaborated with researchers at the University of Arkansas at Fayetteville, including Shengfan Zhang and Maryam Kheirandish, on multiple shared publications. His research is designated as high-impact due to its citation count.
Metrics
- h-index: 23
- Publications: 60
- Citations: 2,104
Positions
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Assistant Professor 2014–presentUniversity of Arkansas Biological Sciences ORCID
Selected Publications
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Cepheid 9-gene host mRNA expression across the spectrum of Mycobacterium tuberculosis infection and disease: insights across the lifespan (2026)
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Microbial Biomarkers of Tuberculosis Infection and Disease in Blood: Systematic Review and Meta-Analysis (2026)
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Microbial biomarkers of tuberculosis infection and disease in blood: systematic review and meta-analysis (2026)
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Minimal immune cell subset differences in a cohort of close contacts of tuberculosis index cases (2025)
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Minimal immune cell subset differences in a cohort of close contacts of tuberculosis index cases (2025)
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Quantifying uncertainty in deep learning binary classification with discrete noise in inputs for risk-based decision making (2025)
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Rapid tuberculosis diagnosis from respiratory or blood samples by a low cost, portable lab-in-tube assay (2025)
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Understanding tuberculosis transmission and progression: A prospective cohort study of index cases and close contacts in Moldova (2024)
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Prospective Exploratory Evaluation of Cepheid Xpert Mycobacterium tuberculosis Host Response Cartridge: A Focus on Adolescents and Young Adults (2024)
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Asynchronous Video Directly Observed Therapy to Monitor Short-Course Latent Tuberculosis Infection Treatment: Results of a Randomized Controlled Trial (2024)
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Identification of differentially recognized T cell epitopes in the spectrum of tuberculosis infection (2024)
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Predicting stringent QuantiFERON-TB Gold Plus conversions in contacts of tuberculosis patients (2023)
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Identification of differentially recognized T cell epitopes in the spectrum of Mtb infection (2023)
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Clinical Evaluation of the XDR-LFC Assay for the Molecular Detection of Isoniazid, Rifampin, Fluoroquinolone, Kanamycin, Capreomycin, and Amikacin Drug Resistance in a Prospective Cohort (2023)
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1539. A Nine-Gene Blood-Based Signature Meets the World Health Organization Target Product Profiles for Diagnosis of Active Tuberculosis and Predicting Progression from Latent to Active Disease (2022)
Collaboration Network
Top Collaborators
- Frequency and Geographic Distribution of gyrA and gyrB Mutations Associated with Fluoroquinolone Resistance in Clinical Mycobacterium Tuberculosis Isolates: A Systematic Review
- Detection of Low-Level Mixed-Population Drug Resistance in Mycobacterium tuberculosis Using High Fidelity Amplicon Sequencing
- Rapid Drug Susceptibility Testing of Drug-Resistant Mycobacterium tuberculosis Isolates Directly from Clinical Samples by Use of Amplicon Sequencing: a Proof-of-Concept Study
- Novel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates
- Whole-genome and targeted sequencing of drug-resistant Mycobacterium tuberculosis on the iSeq100 and MiSeq: A performance, ease-of-use, and cost evaluation
Showing 5 of 37 shared publications
- Frequency and Geographic Distribution of gyrA and gyrB Mutations Associated with Fluoroquinolone Resistance in Clinical Mycobacterium Tuberculosis Isolates: A Systematic Review
- Detection of Low-Level Mixed-Population Drug Resistance in Mycobacterium tuberculosis Using High Fidelity Amplicon Sequencing
- Novel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates
- Performance Comparison of Three Rapid Tests for the Diagnosis of Drug-Resistant Tuberculosis
- A Multinational Analysis of Mutations and Heterogeneity in PZase, RpsA, and PanD Associated with Pyrazinamide Resistance in M/XDR Mycobacterium tuberculosis
Showing 5 of 25 shared publications
- Detection of Low-Level Mixed-Population Drug Resistance in Mycobacterium tuberculosis Using High Fidelity Amplicon Sequencing
- Rapid Drug Susceptibility Testing of Drug-Resistant Mycobacterium tuberculosis Isolates Directly from Clinical Samples by Use of Amplicon Sequencing: a Proof-of-Concept Study
- Performance Comparison of Three Rapid Tests for the Diagnosis of Drug-Resistant Tuberculosis
- Identification of differentially recognized T cell epitopes in the spectrum of tuberculosis infection
- Frequency and Distribution of Tuberculosis Resistance-Associated Mutations between Mumbai, Moldova, and Eastern Cape
Showing 5 of 19 shared publications
- Whole-genome and targeted sequencing of drug-resistant Mycobacterium tuberculosis on the iSeq100 and MiSeq: A performance, ease-of-use, and cost evaluation
- Performance Comparison of Three Rapid Tests for the Diagnosis of Drug-Resistant Tuberculosis
- Frequency and Distribution of Tuberculosis Resistance-Associated Mutations between Mumbai, Moldova, and Eastern Cape
- MTBDR plus and MTBDR sl Assays: Absence of Wild-Type Probe Hybridization and Implications for Detection of Drug-Resistant Tuberculosis
- Increased Tuberculosis Patient Mortality Associated with Mycobacterium tuberculosis Mutations Conferring Resistance to Second-Line Antituberculous Drugs
Showing 5 of 18 shared publications
- Performance Comparison of Three Rapid Tests for the Diagnosis of Drug-Resistant Tuberculosis
- Cost analysis of rapid diagnostics for drug-resistant tuberculosis
- Phenotypic and genotypic diversity in a multinational sample of drug-resistant Mycobacterium tuberculosis isolates
- Prospective Exploratory Evaluation of Cepheid Xpert Mycobacterium tuberculosis Host Response Cartridge: A Focus on Adolescents and Young Adults
- Predicting stringent QuantiFERON-TB Gold Plus conversions in contacts of tuberculosis patients
Showing 5 of 13 shared publications
- Detection of Low-Level Mixed-Population Drug Resistance in Mycobacterium tuberculosis Using High Fidelity Amplicon Sequencing
- Rapid Drug Susceptibility Testing of Drug-Resistant Mycobacterium tuberculosis Isolates Directly from Clinical Samples by Use of Amplicon Sequencing: a Proof-of-Concept Study
- Whole-genome and targeted sequencing of drug-resistant Mycobacterium tuberculosis on the iSeq100 and MiSeq: A performance, ease-of-use, and cost evaluation
- Rapid tuberculosis diagnosis from respiratory or blood samples by a low cost, portable lab-in-tube assay
- Detecting rifampin and isoniazid resistance in Mycobacterium tuberculosis direct from patient sputum using an automated integrated system
Showing 5 of 10 shared publications
- Tuberculosis Treatment Monitoring by Video Directly Observed Therapy in 5 Health Districts, California, USA
- Performance Comparison of Three Rapid Tests for the Diagnosis of Drug-Resistant Tuberculosis
- Rapid tuberculosis diagnosis from respiratory or blood samples by a low cost, portable lab-in-tube assay
- Evaluation of recorded video-observed therapy for anti-tuberculosis treatment
- Increased Tuberculosis Patient Mortality Associated with Mycobacterium tuberculosis Mutations Conferring Resistance to Second-Line Antituberculous Drugs
Showing 5 of 10 shared publications
- Rapid Drug Susceptibility Testing of Drug-Resistant Mycobacterium tuberculosis Isolates Directly from Clinical Samples by Use of Amplicon Sequencing: a Proof-of-Concept Study
- Performance Comparison of Three Rapid Tests for the Diagnosis of Drug-Resistant Tuberculosis
- Frequency and Distribution of Tuberculosis Resistance-Associated Mutations between Mumbai, Moldova, and Eastern Cape
- MTBDR plus and MTBDR sl Assays: Absence of Wild-Type Probe Hybridization and Implications for Detection of Drug-Resistant Tuberculosis
- Increased Tuberculosis Patient Mortality Associated with Mycobacterium tuberculosis Mutations Conferring Resistance to Second-Line Antituberculous Drugs
Showing 5 of 10 shared publications
- Identification of differentially recognized T cell epitopes in the spectrum of tuberculosis infection
- Predicting stringent QuantiFERON-TB Gold Plus conversions in contacts of tuberculosis patients
- Clinical Evaluation of the XDR-LFC Assay for the Molecular Detection of Isoniazid, Rifampin, Fluoroquinolone, Kanamycin, Capreomycin, and Amikacin Drug Resistance in a Prospective Cohort
- Understanding tuberculosis transmission and progression: A prospective cohort study of index cases and close contacts in Moldova
- Identification of differentially recognized T cell epitopes in the spectrum of Mtb infection
Showing 5 of 9 shared publications
- Novel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates
- Performance Comparison of Three Rapid Tests for the Diagnosis of Drug-Resistant Tuberculosis
- Frequency and Distribution of Tuberculosis Resistance-Associated Mutations between Mumbai, Moldova, and Eastern Cape
- MTBDR plus and MTBDR sl Assays: Absence of Wild-Type Probe Hybridization and Implications for Detection of Drug-Resistant Tuberculosis
- Cost analysis of rapid diagnostics for drug-resistant tuberculosis
Showing 5 of 7 shared publications
- Detection of Low-Level Mixed-Population Drug Resistance in Mycobacterium tuberculosis Using High Fidelity Amplicon Sequencing
- Novel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates
- Performance Comparison of Three Rapid Tests for the Diagnosis of Drug-Resistant Tuberculosis
- A Multinational Analysis of Mutations and Heterogeneity in PZase, RpsA, and PanD Associated with Pyrazinamide Resistance in M/XDR Mycobacterium tuberculosis
- Frequency and Distribution of Tuberculosis Resistance-Associated Mutations between Mumbai, Moldova, and Eastern Cape
Showing 5 of 6 shared publications
- Novel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates
- Performance Comparison of Three Rapid Tests for the Diagnosis of Drug-Resistant Tuberculosis
- MTBDR plus and MTBDR sl Assays: Absence of Wild-Type Probe Hybridization and Implications for Detection of Drug-Resistant Tuberculosis
- Cost analysis of rapid diagnostics for drug-resistant tuberculosis
- Shedding light on the performance of a pyrosequencing assay for drug-resistant tuberculosis diagnosis
- Frequency and Distribution of Tuberculosis Resistance-Associated Mutations between Mumbai, Moldova, and Eastern Cape
- MTBDR plus and MTBDR sl Assays: Absence of Wild-Type Probe Hybridization and Implications for Detection of Drug-Resistant Tuberculosis
- Cost analysis of rapid diagnostics for drug-resistant tuberculosis
- Shedding light on the performance of a pyrosequencing assay for drug-resistant tuberculosis diagnosis
- Evaluation of the microscopic observation drug susceptibility assay for the detection of first- and second-line drug susceptibility forMycobacterium tuberculosis
- Detecting rifampin and isoniazid resistance in Mycobacterium tuberculosis direct from patient sputum using an automated integrated system
- Laboratory Evaluation of a Lateral-Flow Cell for Molecular Detection of First-Line and Second-Line Antituberculosis Drug Resistance
- Clinical Evaluation of the XDR-LFC Assay for the Molecular Detection of Isoniazid, Rifampin, Fluoroquinolone, Kanamycin, Capreomycin, and Amikacin Drug Resistance in a Prospective Cohort
- Rapid Detection of Extensively Drug-Resistant Tuberculosis in Clinical Samples Using a Novel Tabletop Platform: Protocol for a Prospective Clinical Study
- Rapid Detection of Extensively Drug-Resistant Tuberculosis in Clinical Samples Using a Novel Tabletop Platform: Protocol for a Prospective Clinical Study (Preprint)
- Identification of differentially recognized T cell epitopes in the spectrum of tuberculosis infection
- Distinct blood transcriptomic signature of treatment in latent tuberculosis infected individuals at risk of developing active disease
- Identification of differentially recognized T cell epitopes in the spectrum of Mtb infection
- Minimal immune cell subset differences in a cohort of close contacts of tuberculosis index cases
- Minimal immune cell subset differences in a cohort of close contacts of tuberculosis index cases
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