Edgar García‐Rill
Prefoessor and Director, Center for Translational Neuroscience
Also affiliated: California Institute of Technology (1974); Arkansas Children's Hospital (2008); United States Department of Veterans Affairs (2005); Centre for Addiction and Mental Health (2016); Inserm (2016); University of California, Los Angeles (1974–1987); The University of Queensland (2016); Université Joseph Fourier (2016); University of Toronto (2016); Universidad de Buenos Aires (2019); Toronto Western Hospital (2016); University of Arkansas Medical Center (2005–2019); University of Chicago (1977–1980); Central Arkansas Veterans Healthcare System (2007); VA Pacific Islands Health Care System (2005); Institut du Cerveau (2016); National Center for Post Traumatic Stress Disorder (2005); Campbell Family Mental Health Research Institute (2016); McGill University (1971–1974)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Edgar García‐Rill's research focuses on the neurobiology of movement and arousal. He investigates the control of voluntary movement and locomotion, with interests in spinal cord injury and motor disorders such as Parkinson's disease and Huntington's disease. His work also explores the mechanisms controlling arousal and sleep-wake cycles, including a recent description of a novel mechanism for sleep-wake control based on electrical coupling.
Dr. García‐Rill directs the Center for Translational Neuroscience at the University of Arkansas for Medical Sciences (UAMS), where he holds professorships in Neurobiology and Developmental Sciences and Psychiatry. He has been continuously funded for his research for over 35 years. His scholarly contributions include 287 publications with over 9,700 citations, and an h-index of 53, designating him as a highly cited researcher. He collaborates with researchers at UAMS, including Aliyah Glover, Lakshmi Pillai, Tuhin Virmani, and Rohit Dhall.
Metrics
- h-index: 52
- Publications: 286
- Citations: 9,751
Positions
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Prefoessor and Director, Center for Translational Neuroscience 1978–presentUniversity of Arkansas for Medical Sciences Neurobiology ORCID
Selected Publications
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Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease (2025)
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Contributors (2021)
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Deep brain stimulation for understanding the sleep-wake phenomena (2021)
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Change in EEG Activity is Associated with a Decrease in Tinnitus Awareness after rTMS. (2021)
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Differential effects of HDAC inhibitors on PPN oscillatory activity in vivo (2019)
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The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics (2019)
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The critical role of persistent sodium current in hippocampal gamma oscillations (2019)
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Proteomic measures of gamma oscillations (2019)
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Focus on the pedunculopontine nucleus. Consensus review from the May 2018 brainstem society meeting in Washington, DC, USA (2019)
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Neuroepigenetics of arousal: Gamma oscillations in the pedunculopontine nucleus (2019)
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HDAC superfamily promoters acetylation is differentially regulated by modafinil and methamphetamine in the mouse medial prefrontal cortex (2019)
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Impaired step‐length setting prior to turning in Parkinson's disease patients with freezing of gait (2018)
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Bottom‐up gamma and bipolar disorder, clinical and neuroepigenetic implications (2018)
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The Critical Role of Intrinsic Membrane Oscillations (2018)
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Class II histone deacetylases require P/Q-type Ca2+ channels and CaMKII to maintain gamma oscillations in the pedunculopontine nucleus (2018)
Collaboration Network
Top Collaborators
- The mesencephalic locomotor region (MLR) in the rat
- The pedunculopontine nucleus—Auditory input, arousal and pathophysiology
- The mesencephalic locomotor region. I. Activation of a medullary projection site
- The mesencephalic locomotor region. II. Projections to reticulospinal neurons
- Chemical activation of the mesecephalic locomotor region
Showing 5 of 75 shared publications
- Coherence and frequency in the reticular activating system (RAS)
- Mechanism behind gamma band activity in the pedunculopontine nucleus
- Modafinil Abrogates Methamphetamine-Induced Neuroinflammation and Apoptotic Effects in the Mouse Striatum
- The physiology of the pedunculopontine nucleus: implications for deep brain stimulation
- Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex
Showing 5 of 44 shared publications
- Modafinil Abrogates Methamphetamine-Induced Neuroinflammation and Apoptotic Effects in the Mouse Striatum
- Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex
- Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice
- Gamma band activity in the RAS-intracellular mechanisms
- Pedunculopontine Nucleus Gamma Band Activity-Preconscious Awareness, Waking, and REM Sleep
Showing 5 of 26 shared publications
- Coherence and frequency in the reticular activating system (RAS)
- Mechanism behind gamma band activity in the pedunculopontine nucleus
- The physiology of the pedunculopontine nucleus: implications for deep brain stimulation
- Gamma band activity in the RAS-intracellular mechanisms
- Spatiotemporal properties of high-speed calcium oscillations in the pedunculopontine nucleus
Showing 5 of 19 shared publications
- The pedunculopontine nucleus—Auditory input, arousal and pathophysiology
- Effects of exercise and fetal spinal cord implants on the H-reflex in chronically spinalized adult rats
- Restoration of frequency-dependent depression of the H-reflex by passive exercise in spinal rats
- Auditory input to the pedunculopontine nucleus: II. Unit responses
- Auditory input to the pedunculopontine nucleus: I. Evoked potentials
Showing 5 of 15 shared publications
- Gamma band activity in the RAS-intracellular mechanisms
- Implications of gamma band activity in the pedunculopontine nucleus
- Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder
- High-threshold Ca2+channels behind gamma band activity in the pedunculopontine nucleus (PPN)
- The 10 Hz frequency: A fulcrum for transitional brain states
Showing 5 of 15 shared publications
- Implications of gamma band activity in the pedunculopontine nucleus
- The 10 Hz frequency: A fulcrum for transitional brain states
- Arousal and the control of perception and movement.
- Pedunculopontine arousal system physiology – Implications for insomnia
- Bottom-up gamma maintenance in various disorders
Showing 5 of 14 shared publications
- Coherence and frequency in the reticular activating system (RAS)
- Mechanism behind gamma band activity in the pedunculopontine nucleus
- The physiology of the pedunculopontine nucleus: implications for deep brain stimulation
- Gamma band activity in the RAS-intracellular mechanisms
- Spatiotemporal properties of high-speed calcium oscillations in the pedunculopontine nucleus
Showing 5 of 12 shared publications
- Gamma band activity in the RAS-intracellular mechanisms
- Pedunculopontine Nucleus Gamma Band Activity-Preconscious Awareness, Waking, and REM Sleep
- Implications of gamma band activity in the pedunculopontine nucleus
- Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder
- High-threshold Ca2+channels behind gamma band activity in the pedunculopontine nucleus (PPN)
Showing 5 of 12 shared publications
- Modafinil Abrogates Methamphetamine-Induced Neuroinflammation and Apoptotic Effects in the Mouse Striatum
- Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex
- Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice
- The effects of single-dose injections of modafinil and methamphetamine on epigenetic and functional markers in the mouse medial prefrontal cortex: potential role of dopamine receptors
- Methamphetamine blunts Ca2+currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex
Showing 5 of 10 shared publications
- Restoration of frequency-dependent depression of the H-reflex by passive exercise in spinal rats
- The onset of hyperreflexia in the rat following complete spinal cord transection
- Evidence for Electrical Coupling in the SubCoeruleus (SubC) Nucleus
- Novel mechanism for hyperreflexia and spasticity
- Wind-up of stretch reflexes as a measure of spasticity in chronic spinalized rats: The effects of passive exercise and modafinil
Showing 5 of 9 shared publications
- Modafinil Abrogates Methamphetamine-Induced Neuroinflammation and Apoptotic Effects in the Mouse Striatum
- Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex
- Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice
- The effects of single-dose injections of modafinil and methamphetamine on epigenetic and functional markers in the mouse medial prefrontal cortex: potential role of dopamine receptors
- Methamphetamine blunts Ca2+currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex
Showing 5 of 9 shared publications
- Electrical Coupling: Novel Mechanism for Sleep-Wake Control
- The Developmental Decrease in REM Sleep: The Role of Transmitters and Electrical Coupling
- The onset of hyperreflexia in the rat following complete spinal cord transection
- Evidence for Electrical Coupling in the SubCoeruleus (SubC) Nucleus
- Novel mechanism for hyperreflexia and spasticity
Showing 5 of 8 shared publications
- Coherence and frequency in the reticular activating system (RAS)
- Mechanism behind gamma band activity in the pedunculopontine nucleus
- Gamma Band Activity in the Reticular Activating System
- The pedunculopontine tegmental nucleus: from basic neuroscience to neurosurgical applications
- Gamma band activity in the developing parafascicular nucleus
Showing 5 of 8 shared publications
- Developmental changes in the effects of serotonin on neurons in the region of the pedunculopontine nucleus
- Developmental Changes in Pedunculopontine Nucleus (PPN) Neurons
- Muscarinic and nicotinic responses in the developing pedunculopontine nucleus (PPN)
- Development of REM sleep drive and clinical implications
- Postnatal maturational properties of rat parafascicular thalamic neurons recorded in vitro
Showing 5 of 8 shared publications
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