Fabricio Medina-Bolívar

Sourced from institutional research profiles (UAMS TRI or ARA).

◆ ARA Academy High Impact

Professor

Arkansas State University

Also affiliated: Pennsylvania State University (1995); Agricultural Research Service (2016); Indiana University Bloomington (2016); National Peanut Research Laboratory (2016); Arkansas Biosciences Institute (2007–2026); Laboratoire d'épistémologie et didactiques des disciplines (2010); Virginia Tech (2003–2005)

24 h-index 63 pubs 1,931 cited

Research Areas

Biomedical Subjects

Links

ORCID Lab Website

Edit your profile

OverviewAI-generated summary

Fabricio Medina-Bolívar's research focuses on the production and characterization of valuable compounds from plant-based systems, particularly hairy root cultures. He has investigated the biosynthesis and purification of stilbenoids like resveratrol, piceatannol, arachidin-1, and arachidin-3 in peanut (Arachis hypogaea) hairy root cultures. His work has explored methods to enhance the production of these phenolic compounds through co-treatments with methyl jasmonate and cyclodextrin, and by manipulating culture medium and growth stages.

Beyond stilbenoids, Medina-Bolívar's research extends to other plant-derived compounds, including camptothecin and its derivatives from Camptotheca acuminata hairy roots. He has also explored the potential of decellularized plants as tissue engineering scaffolds and investigated plant lectins for antigen delivery in mucosal vaccines. His research utilizes advanced analytical techniques, supported by federal grants for UHPLC-TQ and NMR instrumentation from the National Science Foundation (NSF).

Medina-Bolívar holds the designation of an ARA Academy member and is recognized as a highly cited researcher in the field of Plant Biotechnology. His scholarship metrics include an h-index of 24, with over 1,900 citations across 62 publications. He actively collaborates with colleagues at Arkansas State University, including Gaurav Gajurel, Amit Raj Sharma, Robert C. Shields, and Mohammad A. Alam.

Metrics

h-index: 24
Publications: 63
Citations: 1,931

Positions

Director 2022–present

Arkansas State University Molecular Biosciences Graduate Program ORCID
Professor 2009–present

Arkansas State University Biological Sciences Institutional directory

Selected Publications

Design, Synthesis, and Development of 4-[2-[3,5-Bis(trifluoromethyl)anilino]thiazolo-4-yl]phenol as a Dual Inhibitor of Fatty Acid Biosynthesis (FASII) to Clear MRSA Infection (2026)

ChemRxiv 1 citation DOI OpenAlex
High-level production of antibacterial pentacyclic triterpenoids from hairy root cultures of Bixa orellana via abiotic elicitation (2026)

Industrial Crops and Products DOI OpenAlex
Prenylated Stilbenoids Confer Sex-Dependent Cardioprotection in Rats (2025)

Physiology DOI OpenAlex
Enhanced Production of Anti-Inflammatory and Antibacterial Prenylated Isoflavonoids in Pigeon Pea (Cajanus cajan) Hairy Root Cultures (2025)

Journal of Agricultural and Food Chemistry 5 citations DOI OpenAlex
Production of Malheuran A, a Geranylated Flavonoid with Antimicrobial and Anti-Inflammatory Activities, in Hairy Root Cultures of Dalea purpurea (2025)

Plants 4 citations DOI OpenAlex
Stilbene-rich extract increases the cytotoxic effects of paclitaxel in hormone receptor-positive and triple-negative breast cancer spheroids (2024)

Phytomedicine Plus DOI OpenAlex
Water-deficit stress induces prenylated stilbenoid production and affects biomass in peanut hairy roots: Exploring the role of stilbenoid prenyltransferase downregulation (2024)

Plant Physiology and Biochemistry 3 citations DOI OpenAlex
Water Deficit Stress Induces Prenylated Stilbenoid Production and Reduces Root Biomass in Peanut: Role of Stilbenoid Prenyltransferase Downregulation (2024)

SSRN Electronic Journal DOI OpenAlex
Effect of peanut stilbenoids, arachidin-1 and arachidin-3, on Streptococcus mutans growth and acid production (2024)

Natural Product Research 4 citations DOI OpenAlex
Arachidin-1, a Prenylated Stilbenoid from Peanut, Enhances the Anticancer Effects of Paclitaxel in Triple-Negative Breast Cancer Cells (2023)

Cancers 12 citations DOI OpenAlex
Elicitation of Stilbenes and Benzofuran Derivatives in Hairy Root Cultures of White Mulberry (Morus alba) (2022)

Plants 20 citations DOI OpenAlex
Correction: Gajurel et al. Production and Secretion of Isowighteone in Hairy Root Cultures of Pigeon Pea (Cajanus cajan) Co-Treated with Multiple Elicitors. Plants 2022, 11, 834 (2022)

Plants DOI OpenAlex
Induction of the Prenylated Stilbenoids Arachidin-1 and Arachidin-3 and Their Semi-Preparative Separation and Purification from Hairy Root Cultures of Peanut (Arachis hypogaea L.) (2022)

Molecules 18 citations DOI OpenAlex
Production and Secretion of Isowighteone in Hairy Root Cultures of Pigeon Pea (Cajanus cajan) Co-Treated with Multiple Elicitors (2022)

Plants 16 citations DOI OpenAlex
Arachidin-1, a Prenylated Stilbenoid from Peanut, Induces Apoptosis in Triple-Negative Breast Cancer Cells (2022)

International Journal of Molecular Sciences 24 citations DOI OpenAlex

View all publications on OpenAlex →

ARA Academy 2021 ARA Fellow

Dr. Medina-Bolivar has served as faculty at A-State since 2005, directing research at the Arkansas Biosciences Institute. With over 25 years of experience in plant biotechnology, he is recognized globally for pioneering hairy root culture systems to develop natural products. He is a founding member of the American Council for Medicinally Active Plants and was inducted into Arkansas's inaugural Latino Hall of Fame in 2024.

Policy Impact

Over 25 years pioneering plant-based natural product development, strengthening Arkansas State University's biotech research and creating pathways for pharmaceutical commercialization.