Fabricio Medina-Bolívar Institution-verified

Sourced from institutional research profiles (UAMS TRI or ARA).

◆ ARA Academy High Impact

Professor

Arkansas State University

Last publication 2026 Last refreshed 2026-05-22

faculty

23 h-index 59 pubs 1,884 cited

Research Areas

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OverviewAI-generated summary

Fabricio Medina-Bolívar's research focuses on the production and characterization of bioactive compounds from plant sources, particularly prenylated stilbenoids found in peanuts (Arachis hypogaea L.). His work investigates the potential anticancer properties of these compounds, such as Arachidin-1, which has been studied for its ability to induce apoptosis in triple-negative breast cancer cells and enhance the efficacy of chemotherapy drugs like paclitaxel.

Medina-Bolívar utilizes hairy root cultures as a biotechnological platform for the production and enhanced yield of these valuable phytochemicals. His research has involved elicitation strategies to stimulate the production of stilbenes and related derivatives in various plant species, including white mulberry (Morus alba) and pigeon pea (Cajanus cajan). This approach allows for the semi-preparative separation and purification of specific compounds with potential therapeutic applications, including antimicrobial and anti-inflammatory activities.

His scholarship metrics include an h-index of 23, with 59 total publications and 1,863 total citations. Medina-Bolívar is recognized as an ARA Academy member (ARA Fellow) in the field of Plant Biotechnology and is identified as a highly cited researcher. He actively collaborates with researchers at Arkansas State University, including Gaurav Gajurel, Amit Raj Sharma, Robert C. Shields, and Rokib Hasan, with whom he shares numerous publications.

Metrics

h-index: 23
Publications: 59
Citations: 1,884

Selected Publications

Design, Synthesis, and Development of 4-[2-[3,5-Bis(trifluoromethyl)anilino]thiazolo-4-yl]phenol as a Dual Inhibitor of Fatty Acid Biosynthesis (FASII) to Clear MRSA Infection (2026)

DOI OpenAlex
High-level production of antibacterial pentacyclic triterpenoids from hairy root cultures of Bixa orellana via abiotic elicitation (2026)

DOI OpenAlex
Prenylated Stilbenoids Confer Sex-Dependent Cardioprotection in Rats (2025)

DOI OpenAlex
Enhanced Production of Anti-Inflammatory and Antibacterial Prenylated Isoflavonoids in Pigeon Pea (<i>Cajanus cajan</i>) Hairy Root Cultures (2025)

2 citations DOI OpenAlex
Production of Malheuran A, a Geranylated Flavonoid with Antimicrobial and Anti-Inflammatory Activities, in Hairy Root Cultures of Dalea purpurea (2025)

3 citations DOI OpenAlex
Stilbene-rich extract increases the cytotoxic effects of paclitaxel in hormone receptor-positive and triple-negative breast cancer spheroids (2024)

DOI OpenAlex
Water-deficit stress induces prenylated stilbenoid production and affects biomass in peanut hairy roots: Exploring the role of stilbenoid prenyltransferase downregulation (2024)

2 citations DOI OpenAlex
Water Deficit Stress Induces Prenylated Stilbenoid Production and Reduces Root Biomass in Peanut: Role of Stilbenoid Prenyltransferase Downregulation (2024)

DOI OpenAlex
Effect of peanut stilbenoids, arachidin-1 and arachidin-3, on <i>Streptococcus mutans</i> growth and acid production (2024)

2 citations DOI OpenAlex
Arachidin-1, a Prenylated Stilbenoid from Peanut, Enhances the Anticancer Effects of Paclitaxel in Triple-Negative Breast Cancer Cells (2023)

11 citations DOI OpenAlex
Elicitation of Stilbenes and Benzofuran Derivatives in Hairy Root Cultures of White Mulberry (Morus alba) (2022)

16 citations DOI OpenAlex
Correction: Gajurel et al. Production and Secretion of Isowighteone in Hairy Root Cultures of Pigeon Pea (Cajanus cajan) Co-Treated with Multiple Elicitors. Plants 2022, 11, 834 (2022)

DOI OpenAlex
Induction of the Prenylated Stilbenoids Arachidin-1 and Arachidin-3 and Their Semi-Preparative Separation and Purification from Hairy Root Cultures of Peanut (Arachis hypogaea L.) (2022)

16 citations DOI OpenAlex
Production and Secretion of Isowighteone in Hairy Root Cultures of Pigeon Pea (Cajanus cajan) Co-Treated with Multiple Elicitors (2022)

13 citations DOI OpenAlex
Arachidin-1, a Prenylated Stilbenoid from Peanut, Induces Apoptosis in Triple-Negative Breast Cancer Cells (2022)

21 citations DOI OpenAlex

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ARA Academy 2021 ARA Fellow

Dr. Medina-Bolivar has served as faculty at A-State since 2005, directing research at the Arkansas Biosciences Institute. With over 25 years of experience in plant biotechnology, he is recognized globally for pioneering hairy root culture systems to develop natural products. He is a founding member of the American Council for Medicinally Active Plants and was inducted into Arkansas's inaugural Latino Hall of Fame in 2024.

Policy Impact

Over 25 years pioneering plant-based natural product development, strengthening Arkansas State University's biotech research and creating pathways for pharmaceutical commercialization.