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George James Institution-verified

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Federal Grant PI

Professor

Last refreshed 2026-05-08

faculty

PSY Psychiatry, College of Medicine

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Biography and Research Information

OverviewAI-generated summary

George James's research focuses on advancing neuroimaging methodology to understand how the human brain encodes individual differences in cognition. He models brain-behavior relationships in normative samples to identify patterns of functional brain organization that correlate with risk for and recovery from psychiatric and neurologic disorders. His work investigates conditions including addiction, epilepsy, multiple sclerosis, PTSD, and depression.

James is a principal investigator on two federal grants from the National Institute on Drug Abuse, totaling $899,077. One grant, for $394,051, examines the sex-specific roles and neural processing correlates of future outcome estimation in the drug addiction process. The second grant, for $505,026, investigates neurocognitive mechanisms underlying smartphone-assisted prevention of relapse in opioid use disorder. He is a founding faculty member of the UAMS Brain Imaging Research Center, the first research-dedicated human MRI research center in Arkansas.

Research Overview

I joined UAMS as in 2009 as a founding faculty member of the UAMS Brain Imaging Research Center, Arkansas's first research-dedicated human MRI research center. As the BIRC's interim Director and a Professor in Psychiatry and Neurology, my research focuses on advancing neuroimaging methodology to better understand how the human brain encodes individual variance in cognition. By modeling these brain-behavior relationships in normative samples, I seek to identify patterns of functional brain organization that encode risk for and recovery from psychiatric and neurologic disorders including addiction, epilepsy, multiple sclerosis, PTSD, and depression.

Federal Grants 2 $899,077 total

NIH/National Institute on Drug Abuse Contact PI Aug 2021 - May 2027

Neurocognitive Mechanisms Underlying Smartphone-Assisted Prevention of Relapse in Opioid Use Disorder

National Institute on Drug Abuse $505,026 R01
NIH/National Institute on Drug Abuse Contact PI Jul 2018 - Apr 2024

The Sex-specific Roles and Neural Processing Correlates of Future Outcome Estimation in the Drug Addiction Process

National Institute on Drug Abuse $394,051 R01

Grants & Funding

  • Cognitive Control Theoretic Mechanisms of Real-time fMRI-Guided Neuromodulation National Science Foundation Co-Investigator
  • Modeling sex-differences in trauma-related neural organization conferring resilience against addiction NIH Principal Investigator
  • The sex-specific roles and neural processing correlates of future outcome estimation in the drug addiction process - Continuation - Continuation NIH/Nat. Inst. on Drug Abuse Co-Investigator
  • Mapping Brain-Cognition Relationships which Encode Cognitive Deficits in Refractory Epilepsy NIH Principal Investigator
  • Dissecting the Cognitive Roles of Hippocampus NIH/Nat. Inst. of Neurological Disorders & Stroke - Pass Through: Emory University Principal Investigator
  • 1/6 HBCD Prenatal Experiences and Longitudinal Development (PRELUDE) Consortium NIH Co-Investigator
  • Dopamine Enhancement of Fear Extinction Learning in PTSD NIH/Nat. Inst. of Mental Health - Pass Through: University of Wisconsin-Madison Principal Investigator
  • Bupropion for Depression in ESRD Patients on Hemodialysis NIH Co-Investigator

Frequent Collaborators

Gess, Jennifer Han, Xiaotong Mancino, Michael Bollinger, Mary Archer, Robert

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