Gersende Alphonse

OverviewAI-generated summary

Gersende Alphonse, a faculty member at Lyon College, investigates the intersection of radiation therapy, cancer biology, and cellular metabolism. Alphonse's research encompasses advanced radiotherapy techniques and the molecular mechanisms underlying cancer cell response to radiation, with a particular focus on head and neck squamous cell carcinoma. Recent work has explored the role of HIF-1α in DNA double-strand break repair following irradiation, as well as the potential of combining radiation with EGFR and Bcl-2 blockade to target cancer stem cells. Alphonse's group also examines the predictive value of circulating tumor cell detection and protein expression markers in assessing treatment response in patients with oral squamous cell carcinoma. More recently, Alphonse has studied the differential formation of stress granules in radiosensitive and radioresistant cancer cells.

Alphonse's primary research interests include radiation therapy and dosimetry, cancer cells and metastasis, and the interplay between sphingolipid metabolism, cancer, hypoxia, and metabolism.

Metrics

• h-index: 23
• Publications: 98
• Citations: 1,465