J. A. Hinson
Researcher
Also affiliated: Courtauld Institute of Art (1984); University of Copenhagen (1990); National Institutes of Health (1975–1982); Burroughs Wellcome Fund (1993); Lung Institute (1975–1976); National Heart Lung and Blood Institute (1975–1976); Arkansas Department of Agriculture (1987); University of Missouri (1993)
Faculty Researcher
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
J. A. Hinson's research has focused on the mechanisms of action of drugs, particularly in relation to metabolic processes and their impact on disease. This work has explored how these drugs affect cellular functions and potential therapeutic applications. Hinson's publications address fundamental questions in pharmacology and biochemistry, contributing to the understanding of drug interactions within biological systems.
Metrics
- h-index: 20
- Publications: 33
- Citations: 1,638
Selected Publications
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New insights into the mechanisms of acetaminophen toxicity (2010)
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Acetaminophen-Associated Hepatic Injury: Evaluation of Acetaminophen Protein Adducts in Children and Adolescents With Acetaminophen Overdose (2008)
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Western Blot Analysis for Nitrotyrosine Protein Adducts in Livers of Saline-Treated and Acetaminophen-Treated Mice (2000)
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Role of Covalent and Noncovalent Interactions in Cell Toxicity: Effects on Proteins (1992)
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Acetaminophen-induced alterations in pancreatic β cells and serum insulin concentrations in B6C3F1 mice (1990)
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Mechanism of paracetamol toxicity (1990)
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Pretreatment with mixed‐function oxidase inducers increases the sensitivity of the hepatocyte/DNA repair assay (1989)
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Utility of solution electrochemistry mass spectrometry for investigation the formation and detection of biologically important conjugates of acetaminophen (1989)
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The spontaneous and enzymatic reaction of N-acetyl-p-benzoquinonimine with glutathione: A stopped-flow kinetic study (1988)
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Direct analysis of rat bile for acetaminophen and two of its conjugated metabolites via thermospray liquid chromatography/mass spectrometry (1987)
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Fast atom bombardment mass spectrometry and fast atom bombardment mass spectrometry/mass spectrometry of three glutathione conjugates of acetaminophen (1987)
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Mechanisms of acetaminophen oxidation to N-acetyl-P-benzoquinone imine by horseradish peroxidase and cytochrome P-450. (1987)
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The 1- and 2-electron oxidation of acetaminophen catalyzed by prostaglandin H synthase. (1987)
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High resolution mass spectrometric and high-field nuclear magnetic resonance spectroscopic studies of the herbicide propanil, itsN-oxidative decomposition products and related compounds (1986)
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Identification of acetaminophen polymerization products catalyzed by horseradish peroxidase. (1985)
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