J.A. Jamsen

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J.A. Jamsen investigates the molecular mechanisms underlying DNA double-strand break repair, with a particular focus on the role of specialized polymerases. Their research group studies how these enzymes insert nucleotides and the fidelity checkpoints that govern this process. This work aims to understand the structural basis for polymerase proficiency, including how they handle oxidized or damaged nucleotides which can lead to mutations.

Jamsen is the Principal Investigator on a $249,000 grant from the National Institute of Environmental Health Sciences (NIH/NIEHS) for research titled "Molecular Architecture of Oxidative Stress Induced Double Strand Break Repair." This project contributes to the broader understanding of how cells respond to DNA damage, particularly damage caused by oxidative stress, and how errors in repair can contribute to disease. Their recent publications explore the structural dynamics of polymerase insertion events and the function of Polλ in microhomology-mediated end joining, a specific DNA repair pathway.

Metrics

• h-index: 9
• Publications: 32
• Citations: 332