J.A. Jamsen
Assistant Professor
faculty
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Biography and Research Information
OverviewAI-generated summary
J.A. Jamsen's research focuses on the molecular mechanisms of DNA double-strand break repair, particularly the role of DNA polymerases in this process. Jamsen's group investigates how specific polymerases, such as Polλ, contribute to microhomology-mediated end-joining, a critical pathway for repairing DNA damage. Their work also examines the insertion of nucleotides, including oxidized and potentially pro-mutagenic variants, during DNA repair synthesis, aiming to understand the fidelity checkpoints that govern these events.
This research is supported by a $249,000 grant from the NIH/National Institute of Environmental Health Sciences for studying the molecular architecture of oxidative stress-induced double-strand break repair. Jamsen has published 32 papers, accumulating 334 citations and an h-index of 9. The group utilizes various biochemical and structural biology techniques to observe and characterize these complex molecular processes, contributing to a deeper understanding of DNA repair pathways and their implications for cellular health and disease.
Metrics
- h-index: 9
- Publications: 32
- Citations: 337
Selected Publications
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Observing DNA Polymerase Double Strand Break Synthesis (2025)
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Author Correction: Polλ promotes microhomology-mediated end-joining (2023)
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Polλ promotes microhomology-mediated end-joining (2022)
Federal Grants 1 $249,000 total
Molecular Architecture of Oxidative Stress Induced Double Strand Break Repair
Collaboration Network
Top Collaborators
- Polλ promotes microhomology-mediated end-joining
- Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair
- Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide
- Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints
- Author Correction: Polλ promotes microhomology-mediated end-joining
- Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair
- Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide
- Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints
- Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair
- Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide
- Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair
- Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide
- Polλ promotes microhomology-mediated end-joining
- Author Correction: Polλ promotes microhomology-mediated end-joining
- Polλ promotes microhomology-mediated end-joining
- Author Correction: Polλ promotes microhomology-mediated end-joining
- Polλ promotes microhomology-mediated end-joining
- Author Correction: Polλ promotes microhomology-mediated end-joining
- Polλ promotes microhomology-mediated end-joining
- Author Correction: Polλ promotes microhomology-mediated end-joining
- Polλ promotes microhomology-mediated end-joining
- Author Correction: Polλ promotes microhomology-mediated end-joining
- Polλ promotes microhomology-mediated end-joining
- Author Correction: Polλ promotes microhomology-mediated end-joining
- Polλ promotes microhomology-mediated end-joining
- Author Correction: Polλ promotes microhomology-mediated end-joining
- Polλ promotes microhomology-mediated end-joining
- Author Correction: Polλ promotes microhomology-mediated end-joining
- Polλ promotes microhomology-mediated end-joining
- Author Correction: Polλ promotes microhomology-mediated end-joining
- Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair
- Polλ promotes microhomology-mediated end-joining
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