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Presence Current · Arkansas
Last published 2021
Sources OpenAlex · ORCID
Refreshed 2026-08-18

Jai Shankar K. Yadlapalli

Senior Scientist

Faculty Researcher

6 h-index 18 pubs 157 cited

  • Animals
  • Male
  • Rats, Sprague-Dawley
  • Morphine Derivatives
  • Analgesics, Opioid
  • Rats
  • Drug Tolerance
  • Morphine
  • Receptors, Opioid, delta
  • Diabetes Mellitus, Experimental
  • Pain
  • Receptors, Opioid, mu
  • Pain Measurement
  • Pain Management
  • Extraterrestrial Environment

Biography and Research Information

OverviewAI-generated summary

Jai Shankar K. Yadlapalli's research focuses on the pharmacological effects of opioid analgesics, particularly morphine derivatives, in preclinical models. His work has investigated the pharmacokinetics of morphine-6-O-sulfate in rat plasma and brain tissue. This research contributes to understanding drug distribution and metabolism within the central nervous system. Yadlapalli has published 18 papers, accumulating 151 citations, and holds an h-index of 6. His collaborations include shared publications with researchers such as Narsimha Reddy Penthala, Philip J. Breen, Peter A. Crooks, and Zaineb A.F. Albayati, all from the University of Arkansas for Medical Sciences. His recent publication in 2021 indicates continued activity in this research area.

Metrics

  • h-index: 6
  • Publications: 18
  • Citations: 157

Selected Publications

  • A pharmacokinetic study of <scp>morphine‐6‐<i>O</i></scp>‐sulfate in rat plasma and brain (2021)
    Drug Development Research 1 citation DOI OpenAlex
  • Evaluation of morphine‐like effects of the mixed mu/delta agonist morphine‐6‐<i>O</i>‐sulfate in rats: Drug discrimination and physical dependence (2018)
    Pharmacology Research & Perspectives 6 citations DOI OpenAlex
  • Pinprick hypo- and hyperalgesia in diabetic rats: Can diet content affect experimental outcome? (2018)
    Neuroscience Letters 2 citations DOI OpenAlex
  • Preclinical assessment of utility of M6S for multimodal acute and chronic pain treatment in diabetic neuropathy (2017)
    Life Sciences 8 citations DOI OpenAlex
  • Evaluation of Analgesia, Tolerance, and the Mechanism of Action of Morphine-6-O-Sulfate Across Multiple Pain Modalities in Sprague-Dawley Rats (2017)
    Anesthesia & Analgesia 18 citations DOI OpenAlex
  • Stability studies of potent opioid analgesic, morphine‐6‐<i>O‐</i>sulfate in various buffers and biological matrices by HPLC‐DAD analysis (2017)
    Biomedical Chromatography 5 citations DOI OpenAlex
  • X‐irradiation and Simulated Microgravity affects Rat Weight, Food Intake, Insulin and Paw Pressure Pain Threshold (2016)
    The FASEB Journal DOI OpenAlex
  • Antinociceptive effects of the 6- O -sulfate ester of morphine in normal and diabetic rats: Comparative role of mu- and delta-opioid receptors (2016)
    Pharmacological Research 21 citations DOI OpenAlex
  • Degenerative Tissue Responses to Space-like Radiation Doses in a Rodent Model of Simulated Microgravity. (2016)
    PubMed 15 citations OpenAlex
  • Crystal structures of (<i>Z</i>)-5-[2-(benzo[<i>b</i>]thiophen-2-yl)-1-(3,5-dimethoxyphenyl)ethenyl]-1<i>H</i>-tetrazole and (<i>Z</i>)-5-[2-(benzo[<i>b</i>]thiophen-3-yl)-1-(3,4,5-trimethoxyphenyl)ethenyl]-1<i>H</i>-tetrazole (2016)
    Acta Crystallographica Section E Crystallographic Communications 1 citation DOI OpenAlex
  • A novel and efficient tributyltin azide-mediated synthesis of 1H-tetrazolylstilbenes from cyanostilbenes (2016)
    Tetrahedron Letters 14 citations DOI OpenAlex
  • (434) Analgesic profile of morphine 6-O-sulfate sodium: a mixed mu/delta agonist in the treatment of diabetic neuropathic pain (2015)
    Journal of Pain 1 citation DOI OpenAlex
  • Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents (2013)
    MedChemComm 64 citations DOI OpenAlex
  • Seeking Predictable Subject Characteristics That Influence Clinical Trial Discontinuation (2012)
    Drug Information Journal 1 citation DOI OpenAlex

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Collaboration Network

6 Collaborators 1 Institution 1 Country

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