Glenn D. Newport
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Also affiliated: United States Food and Drug Administration (1995–2016); Center for Drug Evaluation and Research (2016)
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Glenn D. Newport is a researcher with a focus on the neurotoxicological effects of various substances, particularly in animal models. His work has investigated the impact of methamphetamine on dopamine pathways in the brain, utilizing rat and mouse models. Newport's research has also explored the neurotoxic properties of peptides and other compounds, examining their effects on brain regions like the hippocampus. He has a publication record of 86 papers, with over 4,240 citations, and an h-index of 31. Newport has collaborated with researchers at the National Center for Toxicological Research, including Qiangen Wu and Syed F. Ali, on multiple shared publications. His recent publications include retraction notices for work on Aβ25–35 peptide and quinolinic acid.
Metrics
- h-index: 30
- Publications: 84
- Citations: 4,173
Selected Publications
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Retraction notice to “On the in vivo early toxic properties of Aβ25–35 peptide in the rat hippocampus: Involvement of the Receptor-for-Advanced Glycation-End-Products and changes in gene expression” [Neurotoxicology and Teratology 33 (2011) 288–296] (2025)
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Retraction notice to “On the early toxic effect of quinolinic acid: Involvement of RAGE” [Neurosci. Lett. 474(2) (2010) 74–78] (2024)
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MicroPET/CT assessment of FDG uptake in brain after long-term methylphenidate treatment in nonhuman primates (2016)
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In Vivo Monitoring of Sevoflurane-induced Adverse Effects in Neonatal Nonhuman Primates Using Small-animal Positron Emission Tomography (2016)
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Positron Emission Tomography with [18F]FLT Revealed Sevoflurane-Induced Inhibition of Neural Progenitor Cell Expansion in vivo (2014)
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Developmental toxicity assay using high content screening of zebrafish embryos (2014)
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Effects of Copper Nanoparticles on Rat Cerebral Microvessel Endothelial Cells (2012)
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MicroPET/CT Imaging of [ 18 F]-FEPPA in the Nonhuman Primate: A Potential Biomarker of Pathogenic Processes Associated with Anesthetic-Induced Neurotoxicity (2012)
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L-carnitine attenuates anesthetic-induced increases in a marker of glial activation in the developing monkey brain (2012)
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Minimally invasive quantitative assessment of inhalation anesthetic-induced brain cell death using microPET imaging (2011)
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RETRACTED: On the in vivo early toxic properties of Aβ25–35 peptide in the rat hippocampus: Involvement of the Receptor-for-Advanced Glycation-End-Products and changes in gene expression (2011)
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Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells (2010)
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Brain microvessel endothelial cells responses to gold nanoparticles:In vitropro-inflammatory mediators and permeability (2010)
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RETRACTED: On the early toxic effect of quinolinic acid: Involvement of RAGE (2010)
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MicroPET imaging of ketamine-induced neuronal apoptosis with radiolabeled DFNSH (2010)
Collaboration Network
Top Collaborators
- Further studies of the role of hyperthermia in methamphetamine neurotoxicity.
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice
- Methamphetamine‐Induced Dopaminergic Neurotoxicity: Role of Peroxynitrite and Neuroprotective Role of Antioxidants and Peroxynitrite Decomposition Catalysts
- Effects of Copper Nanoparticles on Rat Cerebral Microvessel Endothelial Cells
Showing 5 of 47 shared publications
- Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles☆
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice
- Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese, silver, or copper nanoparticles
- Methamphetamine‐Induced Dopaminergic Neurotoxicity: Role of Peroxynitrite and Neuroprotective Role of Antioxidants and Peroxynitrite Decomposition Catalysts
Showing 5 of 35 shared publications
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Effects of Copper Nanoparticles on Rat Cerebral Microvessel Endothelial Cells
- Developmental toxicity assay using high content screening of zebrafish embryos
- In Vivo Monitoring of Sevoflurane-induced Adverse Effects in Neonatal Nonhuman Primates Using Small-animal Positron Emission Tomography
- Oral administration of 3,4-methylenedioxymethamphetamine (MDMA) produces selective serotonergic depletion in the nonhuman primate
Showing 5 of 19 shared publications
- Further studies of the role of hyperthermia in methamphetamine neurotoxicity.
- Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice
- Effects of a cold environment or age on methamphetamine-induced dopamine release in the caudate putamen of female rats
- Parenterally administered 3-nitropropionic acid and amphetamine can combine to produce damage to terminals and cell bodies in the striatum
- Low Environmental Temperatures or Pharmacologic Agents That Produce Hypothermia Decrease Methamphetamine Neurotoxicity in Mice
Showing 5 of 14 shared publications
- Manganese-induced reactive oxygen species: Comparison between Mn+2 and Mn+3
- Effects of a cold environment or age on methamphetamine-induced dopamine release in the caudate putamen of female rats
- Effect of manganese on the concentration of amino acids in different regions of the rat brain
- High-performance liquid chromatographic analysis of estradiol-17β and metabolites in biological media
- Determination of amino acids in different regions of the rat brain application to the acute effects of tetrahydrocannabinol (THC) and trimethyltin (TMT)
Showing 5 of 10 shared publications
- Further studies of the role of hyperthermia in methamphetamine neurotoxicity.
- Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice
- Effects of a cold environment or age on methamphetamine-induced dopamine release in the caudate putamen of female rats
- Low Environmental Temperatures or Pharmacologic Agents That Produce Hypothermia Decrease Methamphetamine Neurotoxicity in Mice
- Development of dopamine and systems in rat brain: the effect of prenatal phencyclidine exposure
Showing 5 of 9 shared publications
- Parenterally administered 3-nitropropionic acid and amphetamine can combine to produce damage to terminals and cell bodies in the striatum
- Determination of d-fenfluramine, d-norfenfluramine and fluoxetine in plasma, brain tissue and brain microdialysate using high-performance liquid chromatography after precolumn derivatization with dansyl chloride
- Determination of d-amphetamine in biological samples using high-performance liquid chromatography after precolumn derivatization with o-phthaldialdehyde and 3-mercaptopropionic acid
- Fenfluramine and Norfenfluramine Levels in Brain Microdialysate, Brain Tissue and Plasma of Rats Administered Doses of d-Fenfluramine Known to Deplete 5-Hydroxytryptamine Levels in Brain
- Central and peripheral neurochemical alterations and immune effects of prenatal ethanol exposure in rats
Showing 5 of 9 shared publications
- Methamphetamine‐Induced Dopaminergic Neurotoxicity: Role of Peroxynitrite and Neuroprotective Role of Antioxidants and Peroxynitrite Decomposition Catalysts
- Peroxynitrite plays a role in methamphetamine‐induced dopaminergic neurotoxicity: evidence from mice lacking neuronal nitric oxide synthase gene or overexpressing copper–zinc superoxide dismutase
- Selenium, an antioxidant, protects against methamphetamine-induced dopaminergic neurotoxicity
- Methamphetamine generates peroxynitrite and produces dopaminergic neurotoxicity in mice: protective effects of peroxynitrite decomposition catalyst
- Ibogaine blocked methamphetamine-induced hyperthermia and induction of heat shock protein in mice
Showing 5 of 8 shared publications
- In Vivo Monitoring of Sevoflurane-induced Adverse Effects in Neonatal Nonhuman Primates Using Small-animal Positron Emission Tomography
- A Minimally Invasive, Translational Biomarker of Ketamine-Induced Neuronal Death in Rats: microPET Imaging Using 18F-Annexin V
- MicroPET imaging of ketamine-induced neuronal apoptosis with radiolabeled DFNSH
- MicroPET/CT Imaging of [ 18 F]-FEPPA in the Nonhuman Primate: A Potential Biomarker of Pathogenic Processes Associated with Anesthetic-Induced Neurotoxicity
- Positron Emission Tomography with [18F]FLT Revealed Sevoflurane-Induced Inhibition of Neural Progenitor Cell Expansion in vivo
Showing 5 of 8 shared publications
- Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles☆
- Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese, silver, or copper nanoparticles
- In Vivo Monitoring of Sevoflurane-induced Adverse Effects in Neonatal Nonhuman Primates Using Small-animal Positron Emission Tomography
- Selective Alterations of Transcription Factors in MPP+-Induced Neurotoxicity in PC12 Cells
- Comparison of the time courses of selective gene expression and dopaminergic depletion induced by MPP+ in MN9D cells
Showing 5 of 8 shared publications
- In Vivo Monitoring of Sevoflurane-induced Adverse Effects in Neonatal Nonhuman Primates Using Small-animal Positron Emission Tomography
- A Minimally Invasive, Translational Biomarker of Ketamine-Induced Neuronal Death in Rats: microPET Imaging Using 18F-Annexin V
- MicroPET imaging of ketamine-induced neuronal apoptosis with radiolabeled DFNSH
- MicroPET/CT Imaging of [ 18 F]-FEPPA in the Nonhuman Primate: A Potential Biomarker of Pathogenic Processes Associated with Anesthetic-Induced Neurotoxicity
- Positron Emission Tomography with [18F]FLT Revealed Sevoflurane-Induced Inhibition of Neural Progenitor Cell Expansion in vivo
Showing 5 of 7 shared publications
- Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese, silver, or copper nanoparticles
- Manganese-induced reactive oxygen species: Comparison between Mn+2 and Mn+3
- Effect of manganese on the concentration of amino acids in different regions of the rat brain
- Selective Alterations of Transcription Factors in MPP+-Induced Neurotoxicity in PC12 Cells
- Comparison of the time courses of selective gene expression and dopaminergic depletion induced by MPP+ in MN9D cells
Showing 5 of 7 shared publications
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Effects of Copper Nanoparticles on Rat Cerebral Microvessel Endothelial Cells
- Brain microvessel endothelial cells responses to gold nanoparticles:In vitropro-inflammatory mediators and permeability
- RETRACTED: On the in vivo early toxic properties of Aβ25–35 peptide in the rat hippocampus: Involvement of the Receptor-for-Advanced Glycation-End-Products and changes in gene expression
- RETRACTED: On the early toxic effect of quinolinic acid: Involvement of RAGE
Showing 5 of 7 shared publications
- Neurochemical and neurohistological alterations in the rat and monkey produced by orally administered methylenedioxymethamphetamine (MDMA)
- Oral administration of 3,4-methylenedioxymethamphetamine (MDMA) produces selective serotonergic depletion in the nonhuman primate
- Parenterally administered 3-nitropropionic acid and amphetamine can combine to produce damage to terminals and cell bodies in the striatum
- Determination of amino acids in different regions of the rat brain application to the acute effects of tetrahydrocannabinol (THC) and trimethyltin (TMT)
- Effect of Trimethyltin on Amino Acid Concentrations in Different Regions of the Mouse Brain
Showing 5 of 6 shared publications
- Developmental toxicity assay using high content screening of zebrafish embryos
- RETRACTED: On the in vivo early toxic properties of Aβ25–35 peptide in the rat hippocampus: Involvement of the Receptor-for-Advanced Glycation-End-Products and changes in gene expression
- RETRACTED: On the early toxic effect of quinolinic acid: Involvement of RAGE
- Retraction notice to “On the early toxic effect of quinolinic acid: Involvement of RAGE” [Neurosci. Lett. 474(2) (2010) 74–78]
- Retraction notice to “On the in vivo early toxic properties of Aβ25–35 peptide in the rat hippocampus: Involvement of the Receptor-for-Advanced Glycation-End-Products and changes in gene expression” [Neurotoxicology and Teratology 33 (2011) 288–296]
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