Laura James Institution-verified
Sourced from institutional research profiles (UAMS TRI or ARA).
Professor
faculty
Peds Pediatrics, College of Medicine
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Laura James is a Professor in the Department of Pediatrics at the University of Arkansas for Medical Sciences, where she also serves as the Director of the Translational Research Institute. Her research focuses on the translational studies of acetaminophen toxicity. In collaboration with other researchers, she has developed novel methods for quantifying acetaminophen protein adducts in peripheral blood samples. Dr. James also leads clinical trials in pediatric populations aimed at establishing safe and effective drug dosing strategies for various diseases.
Prior to her work at UAMS, Dr. James completed her PhD, focusing on behavioral ecology and the molecular mechanisms underlying behavioral phenotypes in agricultural environments, using bees as a model species. Her doctoral research investigated the molecular effects of chronic pesticide exposure on bumblebee learning and memory. This work integrated ecotoxicology, entomology, behavior, and molecular biology, utilizing techniques such as RNA sequencing to analyze gene expression differences.
Research Overview
Dr. James is the Director of the Translational Research Institute at the University of Arkansas for Medical Sciences. Her research interest is in translational studies of acetaminophen toxicity. She and her collaborators developed novel approaches for the quantitation of acetaminophen protein adducts in peripheral blood samples. She also directs clinical trials in children to develop safe and effective drug dosing strategies in a number of disease areas.
ARA Academy 2015 ARA Fellow
Dr. James has served as a pediatrician and UAMS faculty member since 1994. Her research training focused on pediatric pharmacology studies in children, supported by the NIH through the Pediatric Pharmacology Research Unit Network, with emphasis on guiding the dosing of a number of pediatric therapeutics. She now leads the Translational Research Institute at UAMS.
Policy Impact
Leads the UAMS Translational Research Institute, accelerating the translation of laboratory discoveries into clinical treatments that benefit patients across Arkansas.
Growth Areas
['Population Health Innovations & Clinical Research']
Grants & Funding
- Adduct Dipstick for Diagnosis of Acetaminophen Toxicity NIH/NIDDK Principal Investigator
- Engaging Cooperative Sites for Trial Acceleration, Trust, Innovation, and Capability (ECSTATIC) NIH/National Center for Advancing Translational Sciences - Pass Through: Vanderbilt University Principal Investigator
- Synthetic Cannabinoid Toxicity: Role of Biotransformation NIH Co-Investigator
- AcetaSTAT Rapid Assay for Acetaminophen Liver Injury NIH Principal Investigator
- COVID-19 PREVENT (Partnership for Rapid Engagement to enhance Vaccine uptake for Everyone: Neighbors working Together) Project NIH/Nat. Heart, Lung & Blood Institute - Pass Through: Westat Principal Investigator
- No FP attached UAMS ACHRI Flow Through Principal Investigator
- COVID-19 PREVENT (Partnership for Rapid Engagement to enhance Vaccine uptake for Everyone: Neighbors working Together) Project NIH/Nat. Heart, Lung & Blood Institute - Pass Through: Westat Principal Investigator
- COVID-19 PREVENT (Partnership for Rapid Engagement to enhance Vaccine uptake for Everyone: Neighbors working Together) Project NIH/Nat. Heart, Lung & Blood Institute - Pass Through: Westat Principal Investigator
Frequent Collaborators
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