Le Luo Guan Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Professor/Canadian Research Chair (Tier 1)

John Brown University

faculty

72 h-index 439 pubs 19,536 cited

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OverviewAI-generated summary

Le Luo Guan holds a Tier 1 Canada Research Chair and is a professor at John Brown University, focusing on the complex interplay between nutrition, digestive physiology, and the gut microbiome in ruminants. Guan's research group employs multi-omics approaches to investigate host-microbe interactions and their impact on animal health, immunology, and production efficiency. His work has illuminated the role of rumen epithelial interactions in cattle feed efficiency and the long-term effects of ruminal keystone bacteria on lactation performance in dairy goats. Guan's research also addresses practical applications, such as direct-fed microbial supplementation strategies for improved ruminant health and production, as well as the effects of subacute ruminal acidosis on gut health in dairy cows. He has contributed significantly to cataloging the gastrointestinal microbiome of ruminants, with over 10,000 metagenome-assembled genomes. A portion of his work also focuses on infant nutrition and health along with genetic and phenotypic traits in livestock.

Metrics

h-index: 72
Publications: 439
Citations: 19,536

Selected Publications

Invited review: Interplay of rumen microbiome and the cattle host in modulating feed efficiency and methane emissions (2025) DOI
Gut microbiota’s role in high-altitude cognitive impairment: the therapeutic potential of Clostridium sp. supplementation (2024) DOI
Invited review: Impact of maternal health and nutrition on the microbiome and immune development of neonatal calves (2024) DOI
Varied microbial community assembly and specialization patterns driven by early life microbiome perturbation and modulation in young ruminants (2024) DOI
Competitive Analysis of Rumen and Hindgut Microbiota Composition and Fermentation Function in Diarrheic and Non-Diarrheic Postpartum Dairy Cows (2023) DOI
Comparative analysis of functional diversity of rumen microbiome in bison and beef heifers (2023) DOI
Graduate Student Literature Review: Developmental adaptations of immune function in calves and the influence of the intestinal microbiota in health and disease (2023) DOI
Multi-omics revealed the long-term effect of ruminal keystone bacteria and the microbial metabolome on lactation performance in adult dairy goats (2023) DOI
Dynamics of oxidative stress and immune responses in neonatal calves during diarrhea (2023) DOI
Multi-breed host rumen epithelium transcriptome and microbiome associations and their relationship with beef cattle feed efficiency (2023) DOI
Saccharomyces cerevisiae boulardii accelerates intestinal microbiota maturation and is correlated with increased secretory IgA production in neonatal dairy calves (2023) DOI
Translocation of gut microbes to epididymal white adipose tissue drives lipid metabolism disorder under heat stress (2023) DOI
Transcriptome profiling revealed that key rumen epithelium functions change in relation to short-chain fatty acids and rumen epithelium-attached microbiota during the weaning transition (2023) DOI
Microbial Interventions to Improve Neonatal Gut Health (2023) DOI
Maternal rumen and milk microbiota shape the establishment of early-life rumen microbiota in grazing yak calves (2023) DOI