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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
Michael J. Mancino
CAST Program Director
Also affiliated: Michael E. DeBakey VA Medical Center (2014); University of Louisville (1992–1996); Baylor College of Medicine (2014); University of Arkansas Medical Center (2014); VA Boston Healthcare System (2014); Central Arkansas Veterans Healthcare System (2006–2010)
PSY Psychiatry, College of Medicine
16 h-index
57 pubs
903 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Dr. Michael J. Mancino's research focuses on substance use disorders, with a particular emphasis on opioid and stimulant use. He investigates pharmacological and behavioral interventions to improve treatment outcomes for individuals with these conditions.
Dr. Mancino's work includes clinical trials examining the efficacy of medications such as buprenorphine and naltrexone for opioid use disorder. He has also studied the utility of gabapentin in managing stimulant withdrawal and supported the transition to injectable naltrexone. His research explores factors influencing treatment retention and advancement, including the impact of anxiety severity. Additionally, Dr. Mancino investigates trends in stimulant use and disparities in access to detoxification services.
His publications address the development and validation of analytical methods for quantifying medications in biological samples, crucial for pharmacokinetic and pharmacodynamic studies. Dr. Mancino's research network includes collaborators such as Alison Oliveto and Jeff D. Thostenson at the University of Arkansas for Medical Sciences. He is also the CAST Program Director at the UAMS Psychiatric Research Institute, overseeing research and treatment services for addiction.
Research Overview
Dr. Michael J. Mancino is a Professor in the UAMS Department of Psychiatry and the program director of the Center for Addiction Services and Treatment in the Psychiatric Research Institute.
Metrics
- h-index: 16
- Publications: 57
- Citations: 903
Positions
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CAST Program Director 2005–presentUniversity of Arkansas for Medical Sciences PSY Psychiatry, College of Medicine Institutional directory
Selected Publications
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Geospatial ecological momentary assessment (GEMA) for opioid use disorder: Protocol for a just-in-time adaptive intervention (2026)
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Effort and Substance Use: Differentiating Tobacco Use Through Reinforcement Learning of Effort Based Decision Making (2026)
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Randomized, placebo-controlled trial of gabapentin during outpatient buprenorphine-assisted taper and transition to injectable naltrexone (2025)
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Exploratory study of heart rate variability among participants with opioid use disorder inducted on gabapentin versus placebo during outpatient buprenorphine-assisted transition to injection naltrexone. (2025)
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Study Protocol for Implementation of Pharmacist-Led Interventions to Increase Access to Medications for Opioid Use Disorder for Incarcerated Individuals (PLI-MOUD Study) (2025)
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A randomized clinical trial of disulfiram at higher doses for the treatment of cocaine use disorder among methadone-stabilized patients (2025)
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Gabapentin and D-cycloserine alone and in combination with naloxone in methadone-maintained humans responding under a naloxone novel-response discrimination procedure (2025)
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Worsening trends in the frequency of methamphetamine and other stimulant use between treatment admission and discharge (2024)
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THE IMPACT OF FENTANYL ON TREATMENT OUTCOMES DURING AN OUTPATIENT BUPRENORPHINE TAPER WITH ADJUNCT GABAPENTIN (2024)
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Geographic and Racial/Ethnic Differences in Access to Methamphetamine Detoxification Services, United States, 2021 (2024)
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484 A Preliminary Study on the Pharmacodynamics of Oral Cannabis Ingestion in Older Adults (2024)
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Characteristics of patients undergoing medication-assisted treatment for opioid use disorder and their interest in Tai Chi practice (2023)
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289 Heart Rate Variability in Opioid Use Disordered Participants Undergoing Buprenorphine-Assisted Detoxification (2023)
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Smartphone intervention to optimize medication-assisted treatment outcomes for opioid use disorder: study protocol for a randomized controlled trial (2023)
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Smartphone intervention to optimize medication assisted treatment outcomes for opioid use disorder: study protocol for a randomized controlled trial (2023)
Grants & Funding
As listed on this researcher's institutional profile.
- Efficacy of Carvedilol in Recently-Abstinent Psychostimulant Dependent Patients NIH/Nat. Inst. on Drug Abuse via Baylor College of Medicine Co-Investigator
- CTN-0100: Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (RDD) NIH/Nat. Inst. on Drug Abuse via New York University Principal Investigator
- Clinical Trials Network: The Big South/West Node NIH/Nat. Inst. on Drug Abuse via University of Texas Southwestern Medical Center Principal Investigator
- ADAP Substance Abuse Treatment Clinic FY24 Substance Abuse & Mental Health Services Administration via Arkansas Department of Human Services Principal Investigator
- Expanding Infant Mental Health Services in AR Substance Abuse & Mental Health Services Administration via AR Dept of Human Services/Division of Aging and Adult Services Principal Investigator
- University of Arkansas for Medical Sciences - Substance Abuse Treatment Clinic Arkansas Department of Health & Human Services Principal Investigator
- Improving Treatment Outcomes for Prescription Opioid Dependence - Continuation - Continuation - Continuation - Continuation NIH/Nat. Inst. on Drug Abuse Co-Principal Investigator
- Clinical Efficacy of Lisdexamfetamine for Methamphetamine Dependence NIH Principal Investigator
- SOR III Carryforward Justice Involved Individuals Substance Abuse & Mental Health Services Administration via Arkansas Department of Health & Human Services Principal Investigator
- ADAP Substance Abuse Treatment Clinic - Continuation - Continuation - Continuation - Continuation - Continuation Substance Abuse & Mental Health Services Administration via Arkansas Department of Health & Human Services Principal Investigator
- Monoamine Antagonist Therapies for Methamphetamine Abuse NIH/Nat. Inst. on Drug Abuse Co-Investigator
- Impact of CYP2D6 Phenotype on Response to Methamphetamine in Humans NIH/Nat. Inst. on Drug Abuse Co-Investigator
- SOR III Emergency Department Naloxone Project Substance Abuse & Mental Health Services Administration via Arkansas Department of Human Services Principal Investigator
- SOR IV HUB and SPOKE GRANT Substance Abuse & Mental Health Services Administration via Arkansas Department of Human Services Principal Investigator
- Improving Treatment Outcomes for Prescription Opioid Dependence NIH Co-Principal Investigator
- Improving Treatment Strategies for Prescription Opioid Use Disorder- Resubmission NIH Co-Investigator
- MATRIARC Carryforward SORIII FY2024 Substance Abuse & Mental Health Services Administration via Arkansas Department of Health & Human Services Principal Investigator
- Center for Translational Neuroscience NIH Co-Investigator
- Neurocognitive Mechanisms Underlying Smartphone-Assisted Prevention of Relapse in Opioid Use Disorder NIH Co-Investigator
- SOR III MAT Training Carryover FY24 Substance Abuse & Mental Health Services Administration via Arkansas Department of Health & Human Services Principal Investigator
- AN FMRI STUDY OF THE IMPACT OF STRESS ON DRUG ADDICTION NIH/Nat. Inst. on Drug Abuse Co-Investigator
- State Opioid Response Grant for MATRIARC and ECHO Substance Abuse & Mental Health Services Administration via Arkansas Department of Human Services Principal Investigator
- Medication-Assisted Treatment Services using Opioid Use Disorder Substance Abuse & Mental Health Services Administration via Arkansas Department of Human Services Principal Investigator
- Carryover SOR III Emergency Department FY24 Substance Abuse & Mental Health Services Administration via Arkansas Department of Health & Human Services Principal Investigator
Collaboration Network
Top Collaborators
Alison Oliveto
University of Arkansas for Medical Sciences
32 shared publications
In database
- Randomized, double blind, placebo-controlled trial of disulfiram for the treatment of cocaine dependence in methadone-stabilized patients
- Sertraline delays relapse in recently abstinent cocaine‐dependent patients with depressive symptoms
- Characterizing methamphetamine withdrawal in recently abstinent methamphetamine users: a pilot field study
- Randomized, placebo-controlled pilot trial of gabapentin during an outpatient, buprenorphine-assisted detoxification procedure.
- Clinical Efficacy of Sertraline Alone and Augmented With Gabapentin in Recently Abstinent Cocaine-Dependent Patients With Depressive Symptoms
Showing 5 of 32 shared publications
Janette McGaugh
California Wellness Foundation (US)
10 shared publications
- Clinical Efficacy of Sertraline Alone and Augmented With Gabapentin in Recently Abstinent Cocaine-Dependent Patients With Depressive Symptoms
- Open-Label Pilot Study of Modafinil for Methamphetamine Dependence
- Effect of PTSD Diagnosis and Contingency Management Procedures on Cocaine Use in Dually Cocaine‐ and Opioid‐Dependent Individuals Maintained on LAAM: A Retrospective Analysis
- Utility of a controlled amphetamine withdrawal paradigm among adults who use methamphetamine: A pilot clinical trial
- Impact of lisdexamfetamine on retention of methamphetamine-dependent patients in a residential facility
Showing 5 of 10 shared publications
J. Benjamin Guise
University of Arkansas for Medical Sciences
10 shared publications
In database
- Randomized, placebo-controlled pilot trial of gabapentin during an outpatient, buprenorphine-assisted detoxification procedure.
- Clinical Efficacy of Sertraline Alone and Augmented With Gabapentin in Recently Abstinent Cocaine-Dependent Patients With Depressive Symptoms
- Effects of prototypic calcium channel blockers in methadone-maintained humans responding under a naloxone discrimination procedure
- Impact of lisdexamfetamine on retention of methamphetamine-dependent patients in a residential facility
- Efficacy and tolerability of doxazosin in psychostimulant-dependent patients
Showing 5 of 10 shared publications
Jeff Thostenson
University of Arkansas for Medical Sciences
9 shared publications
In database
- Sertraline delays relapse in recently abstinent cocaine‐dependent patients with depressive symptoms
- Randomized, placebo-controlled pilot trial of gabapentin during an outpatient, buprenorphine-assisted detoxification procedure.
- Clinical Efficacy of Sertraline Alone and Augmented With Gabapentin in Recently Abstinent Cocaine-Dependent Patients With Depressive Symptoms
- Moderators of response to sertraline versus placebo among recently abstinent, cocaine dependent patients: A retrospective analysis of two clinical trials
- Survey of Treatment Preferences for Opioid Use Disorder.
Showing 5 of 9 shared publications
Jeff D. Thostenson
University of Arkansas for Medical Sciences
9 shared publications
In database
- Utility of a controlled amphetamine withdrawal paradigm among adults who use methamphetamine: A pilot clinical trial
- Impact of lisdexamfetamine on retention of methamphetamine-dependent patients in a residential facility
- Feasibility and Preliminary Efficacy of Isradipine During Outpatient Buprenorphine Stabilization and Detoxification: A Pilot Randomized, Placebo-Controlled Trial
- Efficacy and tolerability of doxazosin in psychostimulant-dependent patients
- Randomized, placebo-controlled trial of gabapentin during outpatient buprenorphine-assisted taper and transition to injectable naltrexone
Showing 5 of 9 shared publications
Thomas R. Kosten
Michael E. DeBakey VA Medical Center (US)
6 shared publications
- Randomized, double blind, placebo-controlled trial of disulfiram for the treatment of cocaine dependence in methadone-stabilized patients
- Sertraline delays relapse in recently abstinent cocaine‐dependent patients with depressive symptoms
- Clinical Efficacy of Sertraline Alone and Augmented With Gabapentin in Recently Abstinent Cocaine-Dependent Patients With Depressive Symptoms
- Moderators of response to sertraline versus placebo among recently abstinent, cocaine dependent patients: A retrospective analysis of two clinical trials
- Efficacy and tolerability of doxazosin in psychostimulant-dependent patients
Showing 5 of 6 shared publications
Mohit P. Chopra
University of Massachusetts Chan Medical School (US)
6 shared publications
- Adding an Internet-delivered treatment to an efficacious treatment package for opioid dependence.
- Randomized, double blind, placebo-controlled trial of disulfiram for the treatment of cocaine dependence in methadone-stabilized patients
- Clinical Efficacy of Sertraline Alone and Augmented With Gabapentin in Recently Abstinent Cocaine-Dependent Patients With Depressive Symptoms
- Open-Label Pilot Study of Modafinil for Methamphetamine Dependence
- Sex and opioid maintenance dose influence response to naloxone in opioid-dependent humans: A retrospective analysis
Showing 5 of 6 shared publications
Zachary Feldman
University of Arkansas for Medical Sciences (US)
5 shared publications
- Randomized, double blind, placebo-controlled trial of disulfiram for the treatment of cocaine dependence in methadone-stabilized patients
- Characterizing methamphetamine withdrawal in recently abstinent methamphetamine users: a pilot field study
- Open-Label Pilot Study of Modafinil for Methamphetamine Dependence
- Effect of PTSD Diagnosis and Contingency Management Procedures on Cocaine Use in Dually Cocaine‐ and Opioid‐Dependent Individuals Maintained on LAAM: A Retrospective Analysis
- Sex and opioid maintenance dose influence response to naloxone in opioid-dependent humans: A retrospective analysis
Christopher Cargile
University of Arkansas for Medical Sciences
5 shared publications
In database
- Randomized, double blind, placebo-controlled trial of disulfiram for the treatment of cocaine dependence in methadone-stabilized patients
- Clinical Efficacy of Sertraline Alone and Augmented With Gabapentin in Recently Abstinent Cocaine-Dependent Patients With Depressive Symptoms
- Open-Label Pilot Study of Modafinil for Methamphetamine Dependence
- Effects of prototypic calcium channel blockers in methadone-maintained humans responding under a naloxone discrimination procedure
- Gabapentin and D-cycloserine alone and in combination with naloxone in methadone-maintained humans responding under a naloxone novel-response discrimination procedure
W. Brooks Gentry
University of Arkansas for Medical Sciences
4 shared publications
In database
- Randomized, placebo-controlled pilot trial of gabapentin during an outpatient, buprenorphine-assisted detoxification procedure.
- Open-Label Pilot Study of Modafinil for Methamphetamine Dependence
- Effects of prototypic calcium channel blockers in methadone-maintained humans responding under a naloxone discrimination procedure
- Impact of CYP2D6 phenotype on response to methamphetamine in healthy volunteers
Nichole Sanders
University of Arkansas for Medical Sciences (US)
4 shared publications
- Randomized, placebo-controlled pilot trial of gabapentin during an outpatient, buprenorphine-assisted detoxification procedure.
- Clinical Efficacy of Sertraline Alone and Augmented With Gabapentin in Recently Abstinent Cocaine-Dependent Patients With Depressive Symptoms
- Effects of Disulfiram on QTc Interval in Non–Opioid-Dependent and Methadone-Treated Cocaine-Dependent Patients
- Effects of prototypic calcium channel blockers in methadone-maintained humans responding under a naloxone discrimination procedure
Warren K. Bickel
University of Arkansas for Medical Sciences (US)
4 shared publications
- Adding an Internet-delivered treatment to an efficacious treatment package for opioid dependence.
- Hypothetical intertemporal choice and real economic behavior: Delay discounting predicts voucher redemptions during contingency-management procedures.
- Randomized, placebo-controlled pilot trial of gabapentin during an outpatient, buprenorphine-assisted detoxification procedure.
- Effects of prototypic calcium channel blockers in methadone-maintained humans responding under a naloxone discrimination procedure
Merideth A. Addicott
Wake Forest University (US)
4 shared publications
- 289 Heart Rate Variability in Opioid Use Disordered Participants Undergoing Buprenorphine-Assisted Detoxification
- 484 A Preliminary Study on the Pharmacodynamics of Oral Cannabis Ingestion in Older Adults
- Exploratory study of heart rate variability among participants with opioid use disorder inducted on gabapentin versus placebo during outpatient buprenorphine-assisted transition to injection naltrexone.
- Effort and Substance Use: Differentiating Tobacco Use Through Reinforcement Learning of Effort Based Decision Making
James Poling
VA Connecticut Healthcare System (US)
3 shared publications
- Randomized, double blind, placebo-controlled trial of disulfiram for the treatment of cocaine dependence in methadone-stabilized patients
- Sertraline delays relapse in recently abstinent cocaine‐dependent patients with depressive symptoms
- Effect of PTSD Diagnosis and Contingency Management Procedures on Cocaine Use in Dually Cocaine‐ and Opioid‐Dependent Individuals Maintained on LAAM: A Retrospective Analysis
Xiaotong Han
University of Arkansas for Medical Sciences
3 shared publications
In database
- Predictors of Attrition from a National Sample of Methadone Maintenance Patients
- Clearance of buprenorphine during pregnancy and neonatal outcomes
- Impact of state and trait anxiety severity on retention and phase advancement in an outpatient buprenorphine treatment program
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