Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
J
Jeff D. Thostenson
Biostatistician II
Also affiliated: University of Arkansas Medical Center (2014–2026)
17 h-index
50 pubs
1,863 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Jeff D. Thostenson's research investigates biological mechanisms related to bone health and disease, with a particular focus on the role of osteocytes and their interactions with other cells and signaling pathways. His work has explored how endogenous glucocorticoids impact skeletal angiogenesis and strength in aged mice and how osteocyte-derived RANKL contributes to bone resorption in response to dietary calcium deficiency. Thostenson has also studied the necessity of Connexin 43 for the anti-apoptotic effects of bisphosphonates on osteocytes and osteoblasts. His publications include investigations into de novo intracortical bone remodeling and porosity in aging mice, as well as the impact of autophagy deficiency in osteoblasts on bone mass and the osteocyte network. Additionally, his research has touched upon comparative analyses of cannabis and tobacco withdrawal and the assessment of survival predictions for liver transplant patients using MELD measurements. He has a notable publication record with 49 total publications and 1,862 citations, and an h-index of 17.
Metrics
- h-index: 17
- Publications: 50
- Citations: 1,863
Positions
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Biostatistician II 2005–presentUniversity of Arkansas for Medical Sciences Biostatistics ORCID
Selected Publications
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Autophagy in Osx1-Cre-targeted cells is essential for development, growth, and maintenance of bone (2026)
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DMP1-Cre expressing cells mediate the gain in bone mass and strength, but not the increase in bone remodeling, induced by ligands of the parathyroid hormone receptor (2026)
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Beyond contextual smoking norms: The importance of family-level nicotine use risk factors among rural and nonrural youth living in Arkansas (2026)
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Dissecting primary versus secondary effects of osteogenesis imperfecta on abnormal lung development and function (2026)
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Randomized, placebo-controlled trial of gabapentin during outpatient buprenorphine-assisted taper and transition to injectable naltrexone (2025)
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Discontinuation of levothyroxine therapy in patients with subclinical hypothyroidism: a pilot randomized clinical trial (2025)
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Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength (2025)
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Exploratory study of heart rate variability among participants with opioid use disorder inducted on gabapentin versus placebo during outpatient buprenorphine-assisted transition to injection naltrexone. (2025)
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Potent suppression of bone remodeling by denosumab does not blunt the anabolic response to romosozumab in mice (2025)
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Sirtuin-3 promotes osteoclast maturation and bone loss by regulating mitochondrial ROS production during ionizing radiation exposure (2025)
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A randomized clinical trial of disulfiram at higher doses for the treatment of cocaine use disorder among methadone-stabilized patients (2025)
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Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans (2025)
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A Predictive Model for Graves’ Disease Recurrence After Antithyroid Drug Therapy: A Retrospective Multicenter Cohort Study (2024)
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A new Col1a1 conditional knock-in mouse model to study osteogenesis imperfecta (2024)
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CRISPR activation of Tfeb , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength (2024)
Collaboration Network
Top Collaborators
Alison H. Oliveto
University of Arkansas for Medical Sciences
20 shared publications
In database
- Sertraline delays relapse in recently abstinent cocaine‐dependent patients with depressive symptoms
- Randomized, placebo-controlled pilot trial of gabapentin during an outpatient, buprenorphine-assisted detoxification procedure.
- Clinical Efficacy of Sertraline Alone and Augmented With Gabapentin in Recently Abstinent Cocaine-Dependent Patients With Depressive Symptoms
- Utility of a controlled amphetamine withdrawal paradigm among adults who use methamphetamine: A pilot clinical trial
- Moderators of response to sertraline versus placebo among recently abstinent, cocaine dependent patients: A retrospective analysis of two clinical trials
Showing 5 of 20 shared publications
Michael J. Mancino
University of Arkansas for Medical Sciences
18 shared publications
In database
- Sertraline delays relapse in recently abstinent cocaine‐dependent patients with depressive symptoms
- Randomized, placebo-controlled pilot trial of gabapentin during an outpatient, buprenorphine-assisted detoxification procedure.
- Clinical Efficacy of Sertraline Alone and Augmented With Gabapentin in Recently Abstinent Cocaine-Dependent Patients With Depressive Symptoms
- Utility of a controlled amphetamine withdrawal paradigm among adults who use methamphetamine: A pilot clinical trial
- Moderators of response to sertraline versus placebo among recently abstinent, cocaine dependent patients: A retrospective analysis of two clinical trials
Showing 5 of 18 shared publications
Charles A. O’Brien
University of Arkansas for Medical Sciences
18 shared publications
In database
- Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice
- Receptor Activator of Nuclear Factor κB Ligand (RANKL) Protein Expression by B Lymphocytes Contributes to Ovariectomy-induced Bone Loss
- Old age causes de novo intracortical bone remodeling and porosity in mice
- Osteocyte-derived RANKL is a critical mediator of the increased bone resorption caused by dietary calcium deficiency
- Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage
Showing 5 of 18 shared publications
Jinhu Xiong
University of Arkansas for Medical Sciences
14 shared publications
In database
- Receptor Activator of Nuclear Factor κB Ligand (RANKL) Protein Expression by B Lymphocytes Contributes to Ovariectomy-induced Bone Loss
- Old age causes de novo intracortical bone remodeling and porosity in mice
- Osteocyte-derived RANKL is a critical mediator of the increased bone resorption caused by dietary calcium deficiency
- Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage
- Cortical bone loss caused by glucocorticoid excess requires RANKL production by osteocytes and is associated with reduced OPG expression in mice
Showing 5 of 14 shared publications
Melda Onal
University of Arkansas for Medical Sciences
10 shared publications
In database
- Receptor Activator of Nuclear Factor κB Ligand (RANKL) Protein Expression by B Lymphocytes Contributes to Ovariectomy-induced Bone Loss
- Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage
- A Novel Distal Enhancer Mediates Inflammation‐, PTH‐, and Early Onset Murine Kidney Disease‐Induced Expression of the Mouse Fgf23 Gene
- Suppression of autophagy in osteocytes does not modify the adverse effects of glucocorticoids on cortical bone
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
Showing 5 of 10 shared publications
Maria Almeida
University of Arkansas Medical Center
10 shared publications
In database
- Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice
- Receptor Activator of Nuclear Factor κB Ligand (RANKL) Protein Expression by B Lymphocytes Contributes to Ovariectomy-induced Bone Loss
- Old age causes de novo intracortical bone remodeling and porosity in mice
- Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage
- The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are Independent and Mechanistically Distinct
Showing 5 of 10 shared publications
J. Benjamin Guise
University of Arkansas for Medical Sciences
8 shared publications
In database
- Randomized, placebo-controlled pilot trial of gabapentin during an outpatient, buprenorphine-assisted detoxification procedure.
- Clinical Efficacy of Sertraline Alone and Augmented With Gabapentin in Recently Abstinent Cocaine-Dependent Patients With Depressive Symptoms
- Impact of lisdexamfetamine on retention of methamphetamine-dependent patients in a residential facility
- Efficacy and tolerability of doxazosin in psychostimulant-dependent patients
- Randomized, placebo-controlled trial of gabapentin during outpatient buprenorphine-assisted taper and transition to injectable naltrexone
Showing 5 of 8 shared publications
Janette McGaugh
8 shared publications
- Clinical Efficacy of Sertraline Alone and Augmented With Gabapentin in Recently Abstinent Cocaine-Dependent Patients With Depressive Symptoms
- Utility of a controlled amphetamine withdrawal paradigm among adults who use methamphetamine: A pilot clinical trial
- Impact of lisdexamfetamine on retention of methamphetamine-dependent patients in a residential facility
- Feasibility and Preliminary Efficacy of Isradipine During Outpatient Buprenorphine Stabilization and Detoxification: A Pilot Randomized, Placebo-Controlled Trial
- Efficacy and tolerability of doxazosin in psychostimulant-dependent patients
Showing 5 of 8 shared publications
Stavros C. Manolagas
Central Arkansas Veterans Healthcare System
7 shared publications
In database
- Receptor Activator of Nuclear Factor κB Ligand (RANKL) Protein Expression by B Lymphocytes Contributes to Ovariectomy-induced Bone Loss
- Connexin 43 Is Required for the Anti-Apoptotic Effect of Bisphosphonates on Osteocytes and Osteoblasts In Vivo
- Old age causes de novo intracortical bone remodeling and porosity in mice
- Osteocyte-derived RANKL is a critical mediator of the increased bone resorption caused by dietary calcium deficiency
- The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are Independent and Mechanistically Distinct
Showing 5 of 7 shared publications
M. Piemontese
Central Arkansas Veterans Healthcare System (US)
6 shared publications
- Old age causes de novo intracortical bone remodeling and porosity in mice
- Osteocyte-derived RANKL is a critical mediator of the increased bone resorption caused by dietary calcium deficiency
- Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage
- Cortical bone loss caused by glucocorticoid excess requires RANKL production by osteocytes and is associated with reduced OPG expression in mice
- RANKL (Receptor Activator of NFκB Ligand) Produced by Osteocytes Is Required for the Increase in B Cells and Bone Loss Caused by Estrogen Deficiency in Mice
Showing 5 of 6 shared publications
Thomas R. Kosten
Michael E. DeBakey VA Medical Center (US)
5 shared publications
- Sertraline delays relapse in recently abstinent cocaine‐dependent patients with depressive symptoms
- Clinical Efficacy of Sertraline Alone and Augmented With Gabapentin in Recently Abstinent Cocaine-Dependent Patients With Depressive Symptoms
- Moderators of response to sertraline versus placebo among recently abstinent, cocaine dependent patients: A retrospective analysis of two clinical trials
- Efficacy and tolerability of doxazosin in psychostimulant-dependent patients
- Cognitive and cardiovascular effects of carvedilol in recently abstinent, cocaine-dependent patients
Robert S. Weinstein
Central Arkansas Veterans Healthcare System (US)
5 shared publications
- Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice
- Connexin 43 Is Required for the Anti-Apoptotic Effect of Bisphosphonates on Osteocytes and Osteoblasts In Vivo
- Old age causes de novo intracortical bone remodeling and porosity in mice
- Osteocyte-derived RANKL is a critical mediator of the increased bone resorption caused by dietary calcium deficiency
- Suppression of autophagy in osteocytes does not modify the adverse effects of glucocorticoids on cortical bone
Ha‐Neui Kim
University of Arkansas for Medical Sciences
5 shared publications
In database
- Old age causes de novo intracortical bone remodeling and porosity in mice
- The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are Independent and Mechanistically Distinct
- Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence
- Increased marrow adipogenesis does not contribute to age‐dependent appendicular bone loss in female mice
- Sirtuin-3 promotes osteoclast maturation and bone loss by regulating mitochondrial ROS production during ionizing radiation exposure
Robert L. Jilka
University of Arkansas for Medical Sciences
5 shared publications
In database
- Old age causes de novo intracortical bone remodeling and porosity in mice
- The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are Independent and Mechanistically Distinct
- Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence
- Increased marrow adipogenesis does not contribute to age‐dependent appendicular bone loss in female mice
- Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans
Alan Jeffrey Budney
University of Arkansas for Medical Sciences (US)
4 shared publications
- Comparison of cannabis and tobacco withdrawal: Severity and contribution to relapse
- An initial trial of a computerized behavioral intervention for cannabis use disorder
- The impact of disruptive behavior disorder on substance use treatment outcome in adolescents
- Initiation of abstinence in adolescents treated for marijuana use disorders
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