Michele Cottler‐Fox
Professor
Also affiliated: University of Maryland, Baltimore (1996–2003); Brigham and Women's Hospital (1998); Centers for Disease Control and Prevention (1992); National Institutes of Health (1974–1998); Oregon State University (1974–1975); The University of Texas MD Anderson Cancer Center (1998); Georgetown University (1988–1992); University of Utah (2008); University of Michigan (1998); University of Arkansas Medical Center (2004–2026); Georgetown University Medical Center (1988–1991); Albert B. Chandler Hospital (1998); Karolinska Institutet (1979–1987); Central Arkansas Veterans Healthcare System (2006–2008); Cancer Research And Biostatistics (2003); National Heart, Lung, and Blood Institute (1995–1997); National Institute of Neurological Disorders and Stroke (1995); Michigan Medicine (1998); Dana-Farber Cancer Institute (1998–2003); National Cancer Institute (1997); National Cancer Institute (1997); National Institute of Allergy and Infectious Diseases (1975); National Cancer Institute (1974–1997); National Institutes of Health Clinical Center (1992–1995); University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (1996–2003); Georgetown Lombardi Comprehensive Cancer Center (1990–1991); University of Bergen (2013)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Michele Cottler‐Fox, a professor at the University of Arkansas for Medical Sciences, has a research focus that includes hematopoietic stem cell transplantation and multiple myeloma treatments. Her work has investigated long-term outcomes of various therapeutic regimens for multiple myeloma, such as maintenance therapy with VRD (bortezomib, lenalidomide, dexamethasone) and the impact of fractionated melphalan transplants with added bortezomib and thalidomide. Cottler‐Fox also examines operational aspects of cell therapy laboratories, including the effects of new collection goals on apheresis processes and the implications of autologous hematopoietic progenitor cell boosts after CAR-T therapy.
Her research extends to cord blood banking, exploring the barriers and facilitators among pregnant women, including specific investigations into Hispanic populations. Additionally, Cottler‐Fox has contributed to understanding thrombotic microangiopathies, identifying predictors of acquired thrombotic thrombocytopenic purpura (aTTP) using HLA-DR-DQ associations and the PLASMIC score. She leads a research group and collaborates with colleagues at the University of Arkansas for Medical Sciences, including Clyde Bailey and Susan Panozzo. Cottler‐Fox is recognized as a highly cited researcher, with an h-index of 42 and over 200 publications.
Metrics
- h-index: 42
- Publications: 209
- Citations: 6,717
Positions
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Professor 2000–presentUniversity of Arkansas for Medical Sciences Pathology ORCID
Selected Publications
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Post‐transport macroscopic aggregates in a filtered bone marrow harvest bag (2026)
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Barriers and facilitators to, and knowledge of, cord blood banking among pregnant Hispanic women at a university obstetric clinic (2026)
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Impact of New Hematopoietic Progenitor Cell Collection Goals on Apheresis and Cell Therapy Laboratory Services (2025)
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AUTOLOGOUS HEMATOPOIETIC PROGENITOR CELL (HPC) BOOSTS AFTER CHIMERIC ANTIGEN RECEPTOR T-CELL (CAR-T) THERAPY: IMPACT ON THE CELL THERAPY LABORATORY AND STORAGE FACILITY (2025)
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SMALL CHANGES, BIG SAVINGS: IMPACT OF HEMATOPOIETIC PROGENITOR CELLS APHERESIS COLLECTION GOALS ON THE CELL THERAPY LAB (2024)
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HLA-DR-DQ associations, combined with PLASMIC score, are reliable predictors of acquired thrombotic thrombocytopenic purpura (aTTP) and aid in differentiating aTTP from other thrombotic microangiopathies (2024)
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Three years of maintenance with VRD in multiple myeloma: results of total therapy IIIB with a 15-year follow-up (2023)
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Barriers and facilitators to cord blood banking among pregnant women at a university obstetric clinic (2023)
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Hybrid cord blood banks may be advantageous for scientific as well as economic reasons (2020)
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Concepts and Rationale for Using Predictive Algorithms for Hematopoietic Progenitor Cell Apheresis Collection (2019)
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A hands‐on resident umbilical cord blood educational curriculum compared to online education of post‐residency obstetricians: comparison of the volume of collected cord blood units (2019)
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ADAMTS13 Testing Methodologies and Thrombotic Thrombocytopenic Purpura (TTP): Conflicting Results Can Pose a Clinical Dilemma. (2018)
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M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion (2018)
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Optia® continuous mononuclear collection (CMNC) system is a safe and efficient system for hematopoietic progenitor cells‐apheresis (HPC‐a) collection and yields a lower product hematocrit (HCT%) than the COBE® spectra system: A retrospective study (2018)
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Complement Regulatory Genetic Mutations in the Setting of Autoimmune Thrombotic Thrombocytopenic Purpura: A Case Series (2017)
Collaboration Network
Top Collaborators
- A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1
- Incorporating bortezomib into upfront treatment for multiple myeloma: early results of total therapy 3
- Infusion of haplo‐identical killer immunoglobulin‐like receptor ligand mismatched NK cells for relapsed myeloma in the setting of autologous stem cell transplantation
- High response rate in refractory and poor-risk multiple myeloma after allotransplantation using a nonmyeloablative conditioning regimen and donor lymphocyte infusions
- Ex Vivo–expanded Natural Killer Cells Demonstrate Robust Proliferation In Vivo in High-risk Relapsed Multiple Myeloma Patients
Showing 5 of 50 shared publications
- A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1
- Incorporating bortezomib into upfront treatment for multiple myeloma: early results of total therapy 3
- Infusion of haplo‐identical killer immunoglobulin‐like receptor ligand mismatched NK cells for relapsed myeloma in the setting of autologous stem cell transplantation
- Ex Vivo–expanded Natural Killer Cells Demonstrate Robust Proliferation In Vivo in High-risk Relapsed Multiple Myeloma Patients
- Prognostic factors in allogeneic transplantation for patients with high-risk multiple myeloma after reduced intensity conditioning
Showing 5 of 32 shared publications
- A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1
- Incorporating bortezomib into upfront treatment for multiple myeloma: early results of total therapy 3
- Infusion of haplo‐identical killer immunoglobulin‐like receptor ligand mismatched NK cells for relapsed myeloma in the setting of autologous stem cell transplantation
- High response rate in refractory and poor-risk multiple myeloma after allotransplantation using a nonmyeloablative conditioning regimen and donor lymphocyte infusions
- Mobilization of CD34<sup>+</sup> cells in elderly patients (≥ 70 years) with multiple myeloma: influence of age, prior therapy, platelet count and mobilization regimen
Showing 5 of 31 shared publications
- Validation of a formula for predicting daily CD34+ cell collection by leukapheresis
- Hematopoietic progenitor cell collection after autologous transplant for multiple myeloma: low platelet count predicts for poor collection and sole use of resulting graft enhances risk of myelodysplasia
- Analysis of CD34+ cell collection using two mobilization regimens for newly diagnosed multiple myeloma patients reveals the separate impact of mobilization and collection variables
- Rituximab and intermediate-purity plasma-derived factor VIII concentrate (Koate®) as adjuncts to therapeutic plasma exchange for thrombotic thrombocytopenic purpura in patients with an ADAMTS13 inhibitor
- Flow Cytometric Panel-Reactive Antibody Results and the Ability to Find Transfusion-Compatible Platelets after Antibody-Desensitization for Allogeneic Bone Marrow Transplant.
Showing 5 of 17 shared publications
- A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1
- Incorporating bortezomib into upfront treatment for multiple myeloma: early results of total therapy 3
- High response rate in refractory and poor-risk multiple myeloma after allotransplantation using a nonmyeloablative conditioning regimen and donor lymphocyte infusions
- Mobilization of CD34<sup>+</sup> cells in elderly patients (≥ 70 years) with multiple myeloma: influence of age, prior therapy, platelet count and mobilization regimen
- Prognostic factors in allogeneic transplantation for patients with high-risk multiple myeloma after reduced intensity conditioning
Showing 5 of 17 shared publications
- Optia® continuous mononuclear collection (CMNC) system is a safe and efficient system for hematopoietic progenitor cells‐apheresis (HPC‐a) collection and yields a lower product hematocrit (HCT%) than the COBE® spectra system: A retrospective study
- Complement Regulatory Genetic Mutations in the Setting of Autoimmune Thrombotic Thrombocytopenic Purpura: A Case Series
- Hemoglobin Variants Acquired Post-Exchange Transfusion in Pediatric Sickle Cell Disease (SCD) Patients.
- Rituximab and intermediate-purity plasma-derived factor VIII concentrate (Koate®) as adjuncts to therapeutic plasma exchange for thrombotic thrombocytopenic purpura in patients with an ADAMTS13 inhibitor
- Heparin‐induced thrombocytopenia: a cautionary tale
Showing 5 of 15 shared publications
- Infusion of haplo‐identical killer immunoglobulin‐like receptor ligand mismatched NK cells for relapsed myeloma in the setting of autologous stem cell transplantation
- Ex Vivo–expanded Natural Killer Cells Demonstrate Robust Proliferation In Vivo in High-risk Relapsed Multiple Myeloma Patients
- Optimizing dendritic cell‐based immunotherapy in multiple myeloma: intranodal injections of idiotype‐pulsed CD40 ligand‐matured vaccines led to induction of type‐1 and cytotoxic T‐cell immune responses in patients
- Clinical-grade myeloma Ag pre-loaded DC vaccines retain potency after cryopreservation
- Fresh Ex Vivo Expanded Natural Killer Cells Demonstrate Robust Proliferation in Vivo in High-Risk Relapsed Multiple Myeloma (MM) Patients
Showing 5 of 14 shared publications
- High response rate in refractory and poor-risk multiple myeloma after allotransplantation using a nonmyeloablative conditioning regimen and donor lymphocyte infusions
- Mobilization of CD34<sup>+</sup> cells in elderly patients (≥ 70 years) with multiple myeloma: influence of age, prior therapy, platelet count and mobilization regimen
- Prognostic factors in allogeneic transplantation for patients with high-risk multiple myeloma after reduced intensity conditioning
- Improved Outcome of Allogeneic Transplantation in High-Risk Multiple Myeloma Patients After Nonmyeloablative Conditioning
- Transplantation as salvage therapy for high-risk patients with myeloma in relapse
Showing 5 of 14 shared publications
- A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1
- Incorporating bortezomib into upfront treatment for multiple myeloma: early results of total therapy 3
- High response rate in refractory and poor-risk multiple myeloma after allotransplantation using a nonmyeloablative conditioning regimen and donor lymphocyte infusions
- Mobilization of CD34<sup>+</sup> cells in elderly patients (≥ 70 years) with multiple myeloma: influence of age, prior therapy, platelet count and mobilization regimen
- Prognostic factors in allogeneic transplantation for patients with high-risk multiple myeloma after reduced intensity conditioning
Showing 5 of 10 shared publications
- A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1
- Incorporating bortezomib into upfront treatment for multiple myeloma: early results of total therapy 3
- Ex Vivo–expanded Natural Killer Cells Demonstrate Robust Proliferation In Vivo in High-risk Relapsed Multiple Myeloma Patients
- Cancer and the Microenvironment
- Testing standard and genetic parameters in 220 patients with multiple myeloma with complete data sets: superiority of molecular genetics
Showing 5 of 9 shared publications
- A comparison of washed and volume‐reduced platelets with respect to platelet activation, aggregation, and plasma protein removal
- A case of acquired dysfibrinogenemia in multiple myeloma treated with therapeutic plasma exchange
- Autologous Graft versus Host Disease: An Emerging Complication in Patients with Multiple Myeloma
- Rituximab and intermediate-purity plasma-derived factor VIII concentrate (Koate®) as adjuncts to therapeutic plasma exchange for thrombotic thrombocytopenic purpura in patients with an ADAMTS13 inhibitor
- Autologous Graft Versus Host Disease: An Emerging Complication in Patients with Multiple Myeloma
Showing 5 of 8 shared publications
- Infusion of haplo‐identical killer immunoglobulin‐like receptor ligand mismatched NK cells for relapsed myeloma in the setting of autologous stem cell transplantation
- Optimizing dendritic cell‐based immunotherapy in multiple myeloma: intranodal injections of idiotype‐pulsed CD40 ligand‐matured vaccines led to induction of type‐1 and cytotoxic T‐cell immune responses in patients
- Clinical-grade myeloma Ag pre-loaded DC vaccines retain potency after cryopreservation
- Killer Immunoglobulin-Like Receptor Ligand (KIR-Lig) Mismatched Natural Killer (NK) Cell Transfusions for Multiple Myeloma (MM).
- A Novel Strategy for Combining Immunotherapy with High Dose Chemotherapy and Auto-Transplantation in High Risk Multiple Myeloma.
Showing 5 of 8 shared publications
- Autologous Graft versus Host Disease: An Emerging Complication in Patients with Multiple Myeloma
- Flow Cytometric Panel-Reactive Antibody Results and the Ability to Find Transfusion-Compatible Platelets after Antibody-Desensitization for Allogeneic Bone Marrow Transplant.
- Autologous Graft Versus Host Disease: An Emerging Complication in Patients with Multiple Myeloma
- Percent cPRA (Calculated Panel Reactive Antibody) Value Predicts Percent of Positive Platelet Crossmatches.
- 183-P
Showing 5 of 7 shared publications
- A comparison of washed and volume‐reduced platelets with respect to platelet activation, aggregation, and plasma protein removal
- Viability and engraftment of hematopoietic progenitor cells after long-term cryopreservation: effect of diagnosis and percentage dimethyl sulfoxide concentration
- Aldehyde dehydrogenase as an alternative to enumeration of total and viable CD34+ cells in autologous hematopoietic progenitor cell transplantation
- Stromal Elements And Engraftment In Autologous Hematopoietic Progenitor Cell (HPC) Transplant For Myeloma
- Aldehyde Dehydrogenase (ALDH) Vs CD34 for Predicting Engraftment After Autologous Hematopoietic Progenitor Cell (autoHPC) Transplant
Showing 5 of 6 shared publications
- High response rate in refractory and poor-risk multiple myeloma after allotransplantation using a nonmyeloablative conditioning regimen and donor lymphocyte infusions
- Prognostic factors in allogeneic transplantation for patients with high-risk multiple myeloma after reduced intensity conditioning
- Improved Outcome of Allogeneic Transplantation in High-Risk Multiple Myeloma Patients After Nonmyeloablative Conditioning
- ABO mismatch may affect engraftment in multiple myeloma patients receiving nonmyeloablative conditioning
- Autotransplantation for advanced lymphoma and Hodgkin's disease followed by post-transplant rituxan/GM-CSF or radiotherapy and consolidation chemotherapy
Showing 5 of 6 shared publications
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