Biography and Research Information
OverviewAI-generated summary
Nicole Kleinstreuer's research focuses on the development and application of new approach methodologies (NAMs) in toxicology, particularly as alternatives to traditional animal testing. She investigates computational and <i>in silico</i> methods to predict toxicity and facilitate risk assessment, aiming to improve the efficiency and reliability of toxicological evaluations.
Her work includes developing frameworks for establishing scientific confidence in NAMs and evaluating the quality of data used in these models. Kleinstreuer has published on topics such as large-scale modeling of multispecies toxicity, the integration of <i>in vitro</i> data into risk assessment, and the impact of data quality on artificial intelligence models. She is also involved in evaluating variability in animal toxicity studies to better understand and refine alternative testing strategies.
Kleinstreuer's research network includes collaborations with Kamel Mansouri and Weida Tong at the National Center for Toxicological Research, with whom she has co-authored multiple publications. Her scholarship is characterized by a high citation count (13,775) and a significant number of publications (284), reflected in her h-index of 53 and designation as a highly cited researcher.
Metrics
- h-index: 53
- Publications: 284
- Citations: 13,775
Selected Publications
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Challenges and opportunities for validation of AI-based new approach methods (2025)
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The skin allergy risk assessment-integrated chemical environment (SARA-ICE) defined approach to derive points of departure for skin sensitization (2024)
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A Novel Machine Learning Model and a Web Portal for Predicting the Human Skin Sensitization Effects of Chemical Agents (2024)
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Democratizing cheminformatics: interpretable chemical grouping using an automated KNIME workflow (2024)
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Unlocking the Potential of Clustering and Classification Approaches: Navigating Supervised and Unsupervised Chemical Similarity (2024)
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Integrated Approach for Testing and Assessment for Developmental Neurotoxicity (DNT) to Prioritize Aromatic Organophosphorus Flame Retardants (2024)
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Differences in the anatomy and physiology of the human and rat respiratory tracts and impact on toxicological assessments (2024)
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60 Years of the 3Rs symposium: Lessons learned and the road ahead (2024)
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Evaluation of in silico model predictions for mammalian acute oral toxicity and regulatory application in pesticide hazard and risk assessment (2024)
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Use of human predictive patch test (HPPT) data for the classification of skin sensitization hazard and potency (2024)
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Free and open-source QSAR-ready workflow for automated standardization of chemical structures in support of QSAR modeling (2024)
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Artificial intelligence (AI)—it’s the end of the tox as we know it (and I feel fine)* (2024)
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Examining animal testing for risk assessment: A WC-12 workshop report (2024)
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Computational application of internationally harmonized defined approaches to skin sensitization: DASS App (2024)
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Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development (2023)
Collaboration Network
Top Collaborators
David Allen
21 shared publications
- STopTox: An <i>in Silico</i> Alternative to Animal Testing for Acute Systemic and Topical Toxicity
- IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making
- Evaluation of Variability Across Rat Acute Oral Systemic Toxicity Studies
- Application of new approach methodologies: ICE tools to support chemical evaluations
- Analysis of variability in the rabbit skin irritation assay
Showing 5 of 21 shared publications
Judy Strickland
9 shared publications
- STopTox: An <i>in Silico</i> Alternative to Animal Testing for Acute Systemic and Topical Toxicity
- Evaluation of Variability Across Rat Acute Oral Systemic Toxicity Studies
- Application of Defined Approaches for Skin Sensitization to Agrochemical Products
- International regulatory uses of acute systemic toxicity data and integration of new approach methodologies
- The skin allergy risk assessment-integrated chemical environment (SARA-ICE) defined approach to derive points of departure for skin sensitization
Showing 5 of 9 shared publications
Anna Lowit
Environmental Protection Agency (US)
8 shared publications
- A framework for establishing scientific confidence in new approach methodologies
- Human-relevant approaches to assess eye corrosion/irritation potential of agrochemical formulations
- Differences in the anatomy and physiology of the human and rat respiratory tracts and impact on toxicological assessments
- Performance of the GHS Mixtures Equation for Predicting Acute Oral Toxicity
- Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment
Showing 5 of 8 shared publications
Kamel Mansouri
National Institute of Environmental Health Sciences
8 shared publications
In database
- Evaluation of Variability Across Rat Acute Oral Systemic Toxicity Studies
- Application of new approach methodologies: ICE tools to support chemical evaluations
- Free and open-source QSAR-ready workflow for automated standardization of chemical structures in support of QSAR modeling
- Application of an Accessible Interface for Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation
- Quantitative in vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues
Showing 5 of 8 shared publications
Eugene Muratov
University of North Carolina at Chapel Hill (US)
7 shared publications
- STopTox: An <i>in Silico</i> Alternative to Animal Testing for Acute Systemic and Topical Toxicity
- Large-Scale Modeling of Multispecies Acute Toxicity End Points Using Consensus of Multitask Deep Learning Methods
- Curated Data In — Trustworthy <i>In Silico</i> Models Out: The Impact of Data Quality on the Reliability of Artificial Intelligence Models as Alternatives to Animal Testing
- BeeToxAI: An artificial intelligence-based web app to assess acute toxicity of chemicals to honey bees
- Novel computational models offer alternatives to animal testing for assessing eye irritation and corrosion potential of chemicals
Showing 5 of 7 shared publications
Patricia Ceger
Research Triangle Park Foundation (US)
7 shared publications
- IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making
- Analysis of variability in the rabbit skin irritation assay
- Data curation to support toxicity assessments using the Integrated Chemical Environment
- Performance of the GHS Mixtures Equation for Predicting Acute Oral Toxicity
- Quantitative in vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues
Showing 5 of 7 shared publications
Vinícius M. Alves
University of North Carolina at Chapel Hill (US)
6 shared publications
- STopTox: An <i>in Silico</i> Alternative to Animal Testing for Acute Systemic and Topical Toxicity
- Large-Scale Modeling of Multispecies Acute Toxicity End Points Using Consensus of Multitask Deep Learning Methods
- Curated Data In — Trustworthy <i>In Silico</i> Models Out: The Impact of Data Quality on the Reliability of Artificial Intelligence Models as Alternatives to Animal Testing
- BeeToxAI: An artificial intelligence-based web app to assess acute toxicity of chemicals to honey bees
- Novel computational models offer alternatives to animal testing for assessing eye irritation and corrosion potential of chemicals
Showing 5 of 6 shared publications
Alexander Tropsha
University of North Carolina at Chapel Hill (US)
6 shared publications
- STopTox: An <i>in Silico</i> Alternative to Animal Testing for Acute Systemic and Topical Toxicity
- Large-Scale Modeling of Multispecies Acute Toxicity End Points Using Consensus of Multitask Deep Learning Methods
- Curated Data In — Trustworthy <i>In Silico</i> Models Out: The Impact of Data Quality on the Reliability of Artificial Intelligence Models as Alternatives to Animal Testing
- Novel computational models offer alternatives to animal testing for assessing eye irritation and corrosion potential of chemicals
- PreS/MD: Predictor of Sensitization Hazard for Chemical Substances Released From Medical Devices
Showing 5 of 6 shared publications
Neepa Choksi
Research Triangle Park Foundation (US)
5 shared publications
- Application of new approach methodologies: ICE tools to support chemical evaluations
- Analysis of variability in the rabbit skin irritation assay
- Human-relevant approaches to assess eye corrosion/irritation potential of agrochemical formulations
- Data curation to support toxicity assessments using the Integrated Chemical Environment
- Evaluation of the fish acute toxicity test for pesticide registration
James Truax
5 shared publications
- Analysis of variability in the rabbit skin irritation assay
- Application of Defined Approaches for Skin Sensitization to Agrochemical Products
- Use of human predictive patch test (HPPT) data for the classification of skin sensitization hazard and potency
- A database of human predictive patch test data for skin sensitization
- Evaluation of the fish acute toxicity test for pesticide registration
Shannon Bell
Research Triangle Park Foundation (US)
5 shared publications
- IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making
- Application of new approach methodologies: ICE tools to support chemical evaluations
- Data curation to support toxicity assessments using the Integrated Chemical Environment
- Application of an Accessible Interface for Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation
- Quantitative in vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues
Xiaoqing Chang
Research Triangle Park Foundation (US)
5 shared publications
- IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making
- Application of new approach methodologies: ICE tools to support chemical evaluations
- Application of an Accessible Interface for Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation
- Quantitative in vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues
- Integrated Approach for Testing and Assessment for Developmental Neurotoxicity (DNT) to Prioritize Aromatic Organophosphorus Flame Retardants
Agnes L. Karmaus
Syngenta (United States) (US)
5 shared publications
- Evaluation of Variability Across Rat Acute Oral Systemic Toxicity Studies
- Application of new approach methodologies: ICE tools to support chemical evaluations
- Data curation to support toxicity assessments using the Integrated Chemical Environment
- A geospatial modeling approach to quantifying the risk of exposure to environmental chemical mixtures via a common molecular target
- Examining animal testing for risk assessment: A WC-12 workshop report
José Teófilo Moreira‐Filho
National Institute of Environmental Health Sciences (US)
5 shared publications
- BeeToxAI: An artificial intelligence-based web app to assess acute toxicity of chemicals to honey bees
- Free and open-source QSAR-ready workflow for automated standardization of chemical structures in support of QSAR modeling
- Democratizing cheminformatics: interpretable chemical grouping using an automated KNIME workflow
- Unlocking the Potential of Clustering and Classification Approaches: Navigating Supervised and Unsupervised Chemical Similarity
- A Novel Machine Learning Model and a Web Portal for Predicting the Human Skin Sensitization Effects of Chemical Agents
Thomas Härtung
Johns Hopkins University (US)
5 shared publications
- New approach methodologies in human regulatory toxicology – Not if, but how and when!
- Artificial intelligence (AI)—it’s the end of the tox as we know it (and I feel fine)*
- Challenges and opportunities for validation of AI-based new approach methods
- 60 Years of the 3Rs symposium: Lessons learned and the road ahead
- Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development
Similar Researchers
Based on overlapping research topics
Weida Tong
NCTR
Pharmacological Effects and Toxicity Studies
Bioinformatics and Genomic Networks
AI in cancer detection
Leonard A. Harris
University of Arkansas at Fayetteville
Computer Simulation
Bioinformatics and Genomic Networks
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Leihong Wu
National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies
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Me-Kyoung Choi
National Center for Toxicological Research
Risk Assessment
Pharmacological Effects and Toxicity Studies