Nicole Kleinstreuer
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Biography and Research Information
OverviewAI-generated summary
Nicole Kleinstreuer's research focuses on the development and application of new approach methodologies (NAMs) in toxicology, aiming to reduce or replace animal testing. Her work investigates *in silico* (computational) and *in vitro* (cell-based) methods for assessing chemical toxicity and informing regulatory decisions. This includes developing and validating artificial intelligence (AI) models for predicting toxicity endpoints, such as acute systemic and topical toxicity.
Kleinstreuer has contributed to frameworks for establishing scientific confidence in NAMs and has published on the impact of data quality on the reliability of AI models used as alternatives to animal testing. Her research also examines the variability in traditional animal testing protocols, such as acute oral systemic toxicity studies in rats, to identify areas for improvement and comparison with alternative methods. She collaborates with researchers at the National Center for Toxicological Research, including Kamel Mansouri, with whom she has co-authored multiple publications.
With an h-index of 53, 284 total publications, and over 13,775 citations, Kleinstreuer is recognized as a highly cited researcher. Her work supports the broader goal of advancing human regulatory toxicology by integrating computational modeling and high-throughput screening assays into risk assessment processes.
Metrics
- h-index: 53
- Publications: 284
- Citations: 13,775
Selected Publications
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Machine Learning Modeling for ABC Transporter Efflux and Inhibition: Data Curation, Model Development, and New Compound Interaction Predictions (2025)
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External Validation of STopTox – Novel Alternative Method (NAM) for Acute Systemic and Topical Toxicity (2025)
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Panel discussions on the global regulatory acceptance and harmonisation of non-animal NAMs (2025)
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The long way from raw data to NAM-based information: Overview on data layers and processing steps (2025)
Collaboration Network
Top Collaborators
- Panel discussions on the global regulatory acceptance and harmonisation of non-animal NAMs
- The long way from raw data to NAM-based information: Overview on data layers and processing steps
- Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis
- Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis
- Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis
- Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis
- Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis
- Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis
- Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis
- Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis
- Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis
- Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis
- Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis
- Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis
- Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis
- Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis
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