Leonard A. Harris Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Assistant Professor

University of Arkansas for Medical Sciences

faculty

19 h-index 94 pubs 2,022 cited

Research Areas

Cancer-related molecular mechanisms research Computational Drug Discovery Methods Immune Response and Inflammation Metabolism and Genetic Disorders Molecular Biology Techniques and Applications Genomics and Chromatin Dynamics Bioinformatics and Genomic Networks Cancer Cells and Metastasis

Links

ORCID Lab Website

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OverviewAI-generated summary

Leonard A. Harris's research investigates the complex mechanisms underlying human pathologies, with a particular focus on cancer development and cell death processes. His work utilizes computational modeling and multi-omics data integration to understand cellular variability in tumors, exploring genetic, epigenetic, and stochastic factors that contribute to disease progression. Harris has published on topics including the involvement of epithelial-mesenchymal transition genes in small cell lung cancer, the biochemical basis of necroptosis, and unified tumor growth mechanisms derived from multimodel inference.

His research also extends to the development of 'immune digital twins' for studying complex human diseases and the DNA damage response from a whole-cell perspective. He has contributed to the conceptualization of multi-level dynamical modeling for understanding diseases like squamous cell carcinoma. Harris's scholarship metrics include an h-index of 19, 94 total publications, and 2,022 total citations. He has one shared publication with Karthik Nayani from the University of Arkansas at Fayetteville.

Metrics

h-index: 19
Publications: 94
Citations: 2,022

Selected Publications

Capturing Multi-Scale Dynamics of Aortic Valve Calcification With a Coupled Fluid–Structure and Systems Biology Model (2025) DOI
Immune digital twins for complex human pathologies: applications, limitations, and challenges (2024) DOI
Liquid crystalline collagen assemblies as substrates for directed alignment of human Schwann cells (2024) DOI
#52. Computational modeling of signaling pathways and cell-cell interactions driving tumor-induced bone disease (2024) DOI
Concepts of multi-level dynamical modelling: understanding mechanisms of squamous cell carcinoma development in Fanconi anemia (2023) DOI
Concepts of multi-level dynamical modelling: Understanding mechanisms of squamous cell carcinoma development in Fanconi anemia (2023) DOI
Unified tumor growth mechanisms from multimodel inference and dataset integration (2023) DOI
Involvement of Epithelial–Mesenchymal Transition Genes in Small Cell Lung Cancer Phenotypic Plasticity (2023) DOI
A biochemical necroptosis model explains cell-type-specific responses to cell death cues (2023) DOI
Processes in DNA damage response from a whole-cell multi-omics perspective (2022) DOI
Involvement of epithelial-mesenchymal transition genes in small cell lung cancer phenotypic plasticity (2022) DOI
Unified Tumor Growth Mechanisms from Multimodel Inference and Dataset Integration (2022) DOI
Real-time luminescence enables continuous drug–response analysis in adherent and suspension cell lines (2022) DOI
Distinct execution modes of a biochemical necroptosis model explain cell type-specific responses and variability to cell-death cues (2022) DOI
A heterogeneous drug tolerant persister state in BRAF-mutant melanoma is characterized by ion channel dysregulation and susceptibility to ferroptosis (2022) DOI