Nalini S. Bora
Professor
Also affiliated: Howard Hughes Medical Institute (1988–1992); University of Louisville (2001–2006); Duke University (1990); Washington University in St. Louis (1988–2003); University of Arkansas Medical Center (2006–2020); Yale University (2003); Saint Louis University (1994); All India Institute of Medical Sciences (2013)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Nalini S. Bora's research investigates the role of the complement system in ocular diseases, particularly focusing on choroidal neovascularization and uveitis. Her work has explored the expression and function of complement regulatory proteins within the eye and the impact of complement activation pathways, such as the alternative pathway involving Factor B and Factor H, on disease development. She has also studied the involvement of the complement membrane attack complex in laser-induced choroidal neovascularization and the role of complement C3 fragment iC3b in antigen-presenting cells and immune tolerance.
Her research extends to other aspects of ocular inflammation, including the examination of nitric oxide production in endotoxin-induced uveitis in rats. Bora's publications demonstrate a consistent focus on the immunological mechanisms underlying eye diseases. Her scholarly contributions are reflected in a significant publication record and a high h-index of 33, with over 3,400 citations. She is recognized as a highly cited researcher and leads an active research group at the University of Arkansas for Medical Sciences, collaborating with colleagues such as Valeriy V. Lyzogubov and Connor Logan.
Metrics
- h-index: 33
- Publications: 153
- Citations: 3,496
Positions
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Professor 2006–presentUniversity of Arkansas for Medical Sciences Ophthalmology ORCID
Selected Publications
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Role of Adiponectin in the Treatment of Age-Related Macular Degeneration and Other Metabolic Disorders (2024)
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Age-Related Macular Degeneration Models Induced by Polyethylene Glycol (PEG) (2024)
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Role of Complement in the Ocular Immune Response (2024)
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Therapeutic Advancement of Adiponectin in Age-Related Macular Degeneration and Other Metabolic Disorders. (2024)
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Genetic Insights into Age-Related Macular Degeneration (2024)
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Pivotal Roles of APN/AdipoRs Signaling in Maintaining Ocular Homeostasis and Protecting against Eye Ailments (2024)
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Linking Adiponectin and Its Receptors to Age-Related Macular Degeneration (AMD) (2023)
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Obesity Hormone Function in Aging Eyes: Linking Adiponectin and its Receptors to AMD (2023)
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Wet and Dry Age-Related Macular Degeneration Induced by Polyethylene Glycol (2023)
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New Discoveries in Retinal Cell Degeneration and Retinal Diseases (2023)
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Emerging Role of Adiponectin/AdipoRs Signaling in Choroidal Neovascularization, Age-Related Macular Degeneration, and Diabetic Retinopathy (2023)
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Role of Adiponectin Peptide I (APNp1) in Age-Related Macular Degeneration (2022)
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Effects of Lidocaine on Mitomycin C Cytotoxicity (2020)
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Role of thalidomide, senicapoc, and sodium butyrate in choroidal neovascularization (2020)
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Protective role of adiponectin against testicular impairment in high-fat diet/streptozotocin-induced type 2 diabetic mice (2019)
Collaboration Network
Top Collaborators
- Polyethylene Glycol (PEG)-induced Mouse Model of Choroidal Neovascularization
- Recombinant Membrane-targeted Form of CD59 Inhibits the Growth of Choroidal Neovascular Complex in Mice
- Relationship between Complement Membrane Attack Complex, Chemokine (C-C Motif) Ligand 2 (CCL2) and Vascular Endothelial Growth Factor in Mouse Model of Laser-induced Choroidal Neovascularization
- Role of Ocular Complement Factor H in a Murine Model of Choroidal Neovascularization
- Relationship between the complement system, risk factors and prediction models in age-related macular degeneration
Showing 5 of 30 shared publications
- The role of complement system in ocular diseases including uveitis and macular degeneration
- Complement Activation via Alternative Pathway Is Critical in the Development of Laser-Induced Choroidal Neovascularization: Role of Factor B and Factor H
- CD59, a Complement Regulatory Protein, Controls Choroidal Neovascularization in a Mouse Model of Wet-Type Age-Related Macular Degeneration
- The Complement System Plays a Critical Role in the Development of Experimental Autoimmune Anterior Uveitis
- Complement mediated apoptosis leads to the loss of retinal ganglion cells in animal model of glaucoma
Showing 5 of 24 shared publications
- Complement mediated apoptosis leads to the loss of retinal ganglion cells in animal model of glaucoma
- Polyethylene Glycol (PEG)-induced Mouse Model of Choroidal Neovascularization
- Recombinant Membrane-targeted Form of CD59 Inhibits the Growth of Choroidal Neovascular Complex in Mice
- Relationship between Complement Membrane Attack Complex, Chemokine (C-C Motif) Ligand 2 (CCL2) and Vascular Endothelial Growth Factor in Mouse Model of Laser-induced Choroidal Neovascularization
- Role of Ocular Complement Factor H in a Murine Model of Choroidal Neovascularization
Showing 5 of 23 shared publications
- Relationship between the complement system, risk factors and prediction models in age-related macular degeneration
- Inhibition of Complement Alternative Pathway Suppresses Experimental Autoimmune Anterior Uveitis by Modulating T Cell Responses
- Proteolytic Cleavage of Type I Collagen Generates an Autoantigen in Autoimmune Uveitis
- Inhibitory role of transforming growth factor β2 in experimental autoimmune anterior uveitis
- Role of iC3b-CR3 interaction in Experimental Autoimmune Anterior Uveitis
Showing 5 of 14 shared publications
- Role of Complement in Ocular Immune Response
- Crucial Role of Complement Component C3 in Herpes Stromal Keratitis
- Suppression of Complement Factor H Increases Deposition of Membrane Attack Complex and Vessel Growth in Mouse Model of CNV
- Role of T Effector and CD4+CD25+FoxP3+ T Regulatory Cells in Idiopathic Anterior Uveitis
- Role of Complement Factor H (CFH) in Immune Evasion of Uveal Melanoma Cells
Showing 5 of 10 shared publications
- Adiponectin Peptide Inhibits Proliferation of Endothelial Cells and Inhibits Vessel Growth in Mouse Model of Laser Induced CNV
- Relationship Between Complement Activation and Choroidal Neovascularization in Type II Diabetes
- Suppression of Complement Factor H Increases Deposition of Membrane Attack Complex and Vessel Growth in Mouse Model of CNV
- Localization of Adiponectin and Its Receptors in Mouse Model of Choroidal Neovascularization
- Recombinant Membrane-Targeted CD59 Inhibits the Growth of Choroidal Neovascular Complex in Murine Model of Laser-Induced Choroidal Neovascularization (CNV)
Showing 5 of 8 shared publications
- Adiponectin and Chemerin: Contrary Adipokines in Regulating Reproduction and Metabolic Disorders
- Role of adiponectin as a modulator of testicular function during aging in mice
- Protective role of adiponectin against testicular impairment in high-fat diet/streptozotocin-induced type 2 diabetic mice
- Direct actions of adiponectin on changes in reproductive, metabolic, and anti-oxidative enzymes status in the testis of adult mice
- Emerging Role of Adiponectin/AdipoRs Signaling in Choroidal Neovascularization, Age-Related Macular Degeneration, and Diabetic Retinopathy
Showing 5 of 8 shared publications
- Adiponectin Peptide Inhibits Proliferation of Endothelial Cells and Inhibits Vessel Growth in Mouse Model of Laser Induced CNV
- Localization of Adiponectin and Its Receptors in Mouse Model of Choroidal Neovascularization
- Role of Complement Regulatory Protein, CD59, in the Development of Choroidal Neovascularization in a Mouse Model of Wet-Type Age-Related Macular Degeneration
- Therapeutic Potential of Recombinant Membrane-Targeted Form of MAC Regulator CD59 in Laser-Induced CNV
- The Role of Complement in Herpes Stromal Keratitis
Showing 5 of 7 shared publications
- Complement Activation via Alternative Pathway Is Critical in the Development of Laser-Induced Choroidal Neovascularization: Role of Factor B and Factor H
- The Complement System Plays a Critical Role in the Development of Experimental Autoimmune Anterior Uveitis
- Suppression of Complement Regulatory Proteins (CRPs) Exacerbates Experimental Autoimmune Anterior Uveitis (EAAU)
- Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularization
- Complement, Innate Immunity and Ocular Disease
Showing 5 of 7 shared publications
- Complement Activation via Alternative Pathway Is Critical in the Development of Laser-Induced Choroidal Neovascularization: Role of Factor B and Factor H
- The Complement System Plays a Critical Role in the Development of Experimental Autoimmune Anterior Uveitis
- Suppression of Complement Regulatory Proteins (CRPs) Exacerbates Experimental Autoimmune Anterior Uveitis (EAAU)
- Complement, Innate Immunity and Ocular Disease
- Complement System and the Eye
Showing 5 of 6 shared publications
- The Complement System Plays a Critical Role in the Development of Experimental Autoimmune Anterior Uveitis
- Inhibition of Complement Alternative Pathway Suppresses Experimental Autoimmune Anterior Uveitis by Modulating T Cell Responses
- Proteolytic Cleavage of Type I Collagen Generates an Autoantigen in Autoimmune Uveitis
- Suppression of complement activation by recombinant Crry inhibits experimental autoimmune anterior uveitis (EAAU)
- Role of Classical, Alternative and Lectin Pathways in the Induction of Experimental Autoimmune Anterior Uveitis (EAAU)
Showing 5 of 6 shared publications
- Adiponectin and Chemerin: Contrary Adipokines in Regulating Reproduction and Metabolic Disorders
- Role of adiponectin as a modulator of testicular function during aging in mice
- Protective role of adiponectin against testicular impairment in high-fat diet/streptozotocin-induced type 2 diabetic mice
- Direct actions of adiponectin on changes in reproductive, metabolic, and anti-oxidative enzymes status in the testis of adult mice
- Systemic adiponectin treatment reverses polycystic ovary syndrome-like features in an animal model
Showing 5 of 6 shared publications
- Complement Activation via Alternative Pathway Is Critical in the Development of Laser-Induced Choroidal Neovascularization: Role of Factor B and Factor H
- CD59, a Complement Regulatory Protein, Controls Choroidal Neovascularization in a Mouse Model of Wet-Type Age-Related Macular Degeneration
- Recombinant Membrane-targeted Form of CD59 Inhibits the Growth of Choroidal Neovascular Complex in Mice
- Expression of adiponectin in choroidal tissue and inhibition of laser induced choroidal neovascularization by adiponectin
- Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularization
- Complement Activation via Alternative Pathway Is Critical in the Development of Laser-Induced Choroidal Neovascularization: Role of Factor B and Factor H
- CD59, a Complement Regulatory Protein, Controls Choroidal Neovascularization in a Mouse Model of Wet-Type Age-Related Macular Degeneration
- The Complement System Plays a Critical Role in the Development of Experimental Autoimmune Anterior Uveitis
- Suppression of Complement Regulatory Proteins (CRPs) Exacerbates Experimental Autoimmune Anterior Uveitis (EAAU)
- Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularization
- Adiponectin and Chemerin: Contrary Adipokines in Regulating Reproduction and Metabolic Disorders
- Systemic adiponectin treatment reverses polycystic ovary syndrome-like features in an animal model
- Direct action of adiponectin ameliorates increased androgen synthesis and reduces insulin receptor expression in the polycystic ovary
- Therapeutic Advancement of Adiponectin in Age-Related Macular Degeneration and Other Metabolic Disorders.
- Role of Adiponectin in the Treatment of Age-Related Macular Degeneration and Other Metabolic Disorders
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