Richard C. Kurten

High Impact

Researcher

University of Arkansas for Medical Sciences

faculty

31 h-index 123 pubs 3,564 cited

Research Areas

Immune Response and Inflammation SARS-CoV-2 and COVID-19 Research Microbial infections and disease research Asthma and respiratory diseases Eosinophilic Esophagitis Protein Structure and Dynamics Cellular transport and secretion

Links

ORCID Lab Website

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OverviewAI-generated summary

Richard C. Kurten's research focuses on the molecular and cellular mechanisms underlying various human diseases, including respiratory conditions and inflammatory disorders. His work has investigated the role of specific proteins and signaling pathways in disease pathogenesis. For instance, he has studied the impact of mucins MUC5AC and MUC5B on cellular processes and the function of the cytokine TNFSF14/LIGHT in regulating inflammation and tissue remodeling in conditions like eosinophilic esophagitis. Kurten's research also extends to the characterization of the extracellular matrix proteome in esophageal diseases and the influence of ORMDL3 expression on airway smooth muscle cell behavior.

Further contributing to the understanding of respiratory illnesses, Kurten has explored the effects of viral infections on human airways. His recent publications include studies on how Rhinovirus C15 impacts airway relaxation and cAMP production, and the use of human precision-cut lung slices as a platform to study SARS-CoV-2 pathogenesis and antiviral efficacy. He has also investigated the potential of neurotransmitter system-targeting drugs in combating the growth of pathogens like Coxiella burnetii in human cells.

Kurten's scholarly output includes 123 publications, with a total of 3,564 citations, and an h-index of 31. He is recognized as a highly cited researcher. His collaborations at the University of Arkansas for Medical Sciences include work with Joshua L. Kennedy, Priyangi A. Malaviarachchi, Duah Alkam, and Srijon K. Banerjee.

Metrics

  • h-index: 31
  • Publications: 123
  • Citations: 3,564

Selected Publications

  • An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy (2024) DOI
  • Mechanotransduction-induced interplay between phospholamban and yes-activated protein induces smooth muscle cell hypertrophy (2024) DOI
  • Rhinovirus C15 Attenuates Relaxation and cAMP Production in Human Airways and Smooth Muscle (2023) DOI
  • An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy (2023) DOI
  • A Deficiency in the Cytokine TNFSF14/LIGHT Limits Inflammation and Remodeling in Murine Eosinophilic Esophagitis (2022) DOI
  • Mucin Expression in Human Precision-Cut Lung Slices (2022) DOI
  • Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules (2022) DOI
  • Reduced AIBP expression in bronchial epithelial cells of asthmatic patients: Potential therapeutic target (2022) DOI
  • Esophageal Fibroblasts are the Players in the Interferon Response in Eosinophilic Esophagitis (2022) DOI
  • LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms (2021) DOI
  • Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells (2021) DOI
  • ORMDL3 expression in ASM regulates hypertrophy, hyperplasia via TPM1 and TPM4, and contractility (2021) DOI
  • Integrative Proteomics and Phosphoproteomics of Asthmatic Airways following RV Infection (2021) DOI
  • A unique esophageal extracellular matrix proteome alters normal fibroblast function in severe eosinophilic esophagitis (2021) DOI

Collaborators

Researchers in the database who share publications

Joshua L. Kennedy University of Arkansas for Medical Sciences 4 shared publications Priyangi A. Malaviarachchi University of Arkansas for Medical Sciences 2 shared publications Duah Alkam University of Arkansas for Medical Sciences 2 shared publications Srijon K. Banerjee University of Arkansas for Medical Sciences 2 shared publications Daniel E. Voth University of Arkansas for Medical Sciences 1 shared publication Marissa S. Fullerton University of Arkansas for Medical Sciences 1 shared publication Punsiri M. Colonne University of Arkansas for Medical Sciences 1 shared publication Katelynn R. Brann University of Arkansas for Medical Sciences 1 shared publication

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