Stephanie D. Byrum

High Impact

Researcher

UAMS

Last publication 2026 Last refreshed 2026-05-16

faculty

33 h-index 291 pubs 4,396 cited

Research Areas

Links

ORCID Lab Website Research Group UAMS TRI Profile

OverviewAI-generated summary

Stephanie D. Byrum's research focuses on molecular mechanisms underlying cancer development and potential therapeutic strategies. Her work investigates the role of protein complexes and epigenetic modifications in cellular processes that can lead to disease. She has published research on how phase separation affects chromatin looping and contributes to cancer progression, and how specific enzymes like CDK8 and CDK19 regulate gene transcription. Additionally, her group has explored targeted therapies, including PROTACs (proteolysis-targeting chimeras), to suppress oncogenic pathways, such as those involving NSD3 and c-Myc. Other areas of her research include the engagement of histone modifications like H3K9me3 in silencing endogenous retroviruses and the impact of PCSK9 on endothelial cell function and vascular aging.

Byrum is also involved in developing and applying proteomic techniques. She has contributed to the development of a package for quantitative proteomics, proteoDA. Her research network includes extensive collaboration with colleagues at the University of Arkansas for Medical Sciences, including Samuel G. Mackintosh, Alan J. Tackett, Charity L. Washam, and Aaron J. Storey, with whom she has co-authored numerous publications. Her work has been recognized with a designation as a highly cited researcher, evidenced by an h-index of 33 and over 4,300 citations across her 284 publications.

Metrics

h-index: 33
Publications: 291
Citations: 4,396

Selected Publications

Gonadotrope Remodeling in Sustained Low Estrogen States: Single-Cell Transcriptomic Analysis Reveals Gonadotrope Subtypes and Activation of Stem Cell Populations. (2026)

DOI OpenAlex
Guanylate-binding proteins balance iNOS/Arg-1 in myeloid cells during L. major infection and promote host defense to infection (2026)

DOI OpenAlex
SAT-001 Impact of VCD-induced Menopause on Gonadotrope Transcriptomics Reveals Estrogen-dependent Genes in the GnRH Signaling Pathway (2025)

DOI OpenAlex
Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG (2025)

3 citations DOI OpenAlex
High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes (2025)

DOI OpenAlex
Guanylate-Binding Proteins Promote Host Defense Against Leishmania major by Balancing iNOS/Arg-1 in Myeloid Cells (2025)

DOI OpenAlex
Protective effects of factor XI inhibition by abelacimab in a baboon model of live Staphylococcus aureus sepsis (2025)

2 citations DOI OpenAlex
Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB (2025)

DOI OpenAlex
BRCA1 influences whole body metabolism in humanized mice (2025)

2 citations DOI OpenAlex
Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice (2025)

3 citations DOI OpenAlex
The phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators (2025)

18 citations DOI OpenAlex
Staphylococcus aureus Proteins Implicated in the Reduced Virulence of sarA and sarA/agr Mutants in Osteomyelitis (2025)

5 citations DOI OpenAlex
Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants (2024)

1 citation DOI OpenAlex
8572 A 30% Maternal Caloric Restriction Alters Expression of Musashi Targets in the Neonatal and Adult Pituitary Proteomes of FVB Mice (2024)

DOI OpenAlex
A three-dimensional valve-on-chip microphysiological system implicates cell cycle progression, cholesterol metabolism and protein homeostasis in early calcific aortic valve disease progression (2024)

8 citations DOI OpenAlex