Spyridoula Maraka
Associate Professor
Also affiliated: Mayo Clinic (2014–2025); University of Connecticut (2012–2016); University of Arkansas Medical Center (2020–2022); WinnMed (2014–2018); Arkansas Cardiology (2020–2024); Central Arkansas Veterans Healthcare System (2017–2026); Mayo Clinic in Arizona (2015–2025); Mayo Clinic in Florida (2015–2025); Arkansas Department of Agriculture (2019–2025); Institute of Nutrition, Metabolism and Diabetes (2021–2022)
Faculty Researcher
Internal Med, College of Medicine
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Spyridoula Maraka's research program focuses on patient-centered, evidence-based endocrine care, with a particular emphasis on outcome analysis, evidence synthesis, decision-making, and health services delivery. Her work extensively investigates subclinical hypothyroidism and its implications across various patient populations.
Her publications include a systematic review and meta-analysis on the association between maternal thyroid function and the risk of gestational hypertension and pre-eclampsia, as well as research on levothyroxine use in the United States. Maraka has also published on the benefits and harms of different levothyroxine therapies for adult hypothyroidism, reference intervals for thyroid-stimulating hormone and free thyroxine during pregnancy, and the outcomes of levothyroxine treatment in women with subclinical hypothyroidism based on new diagnostic criteria. Further research explores the association of thyroid function with suicidal behavior and the relationship between thyroid antibodies and thyroid function in pregnancy.
Maraka holds an h-index of 33 and has authored 137 publications with nearly 4,000 citations. She leads a research group and collaborates with several colleagues at the University of Arkansas for Medical Sciences, including Arwa Albashaireh and Richard R. Owen.
Research Overview
Clinical Practice: General endocrinology with emphasis on thyroid disorders Research Interests: Promotion of patient-centered, evidence based endocrine care through a research program focusing on outcome analysis, evidence synthesis, decision making, and health services delivery. Main focus: subclinical hypothyroidism.
Metrics
- h-index: 33
- Publications: 137
- Citations: 4,034
Selected Publications
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American Thyroid Association 2026 Guidelines for Thyroid Disease in Preconception, Pregnancy, and Postpartum (2026)
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Use of a capillary blood collection device to monitor exposure to per- and polyfluoroalkyl substances (PFAS) in Veterans living in proximity to potential sources of environmental contamination (2026)
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A comparison of bilateral internal jugular vein sampling with bilateral inferior petrosal sinus sampling at Mayo Clinic for the subtype evaluation of corticotropin-dependent cushing syndrome (2025)
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Do all superheroes wear capes? A case–control study of the highest grossing superhero movies (2025)
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Discontinuation of levothyroxine therapy in patients with subclinical hypothyroidism: a pilot randomized clinical trial (2025)
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Levothyroxine in Pregnancy: Protective Neurodevelopmental Role Beyond Cognitive Outcomes? (2025)
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Risk Factors for Thyroid Function Test Abnormalities During Pregnancy: A Systematic Review of the Literature to Validate Current Risk Factors and Identify Novel Ones (2025)
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Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans (2025)
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Frequency and Determinants of Levothyroxine Therapy Initiation for Veterans with Subclinical Hypothyroidism (2024)
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Subclinical Hypothyroidism and Thyroid Autoimmunity in Pregnancy (2024)
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Interventions to improve symptomatology in patients with hypothyroidism and persistent symptoms: A systematic review (2024)
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Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis (2024)
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Thyroid storm in pregnancy: a review (2024)
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Trends and Components of Thyroid Status Evaluation in Commercially Insured Adults in the United States, 2006-2020 (2023)
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Interventions to improve symptomatology in patients with hypothyroidism and persistent symptoms: A systematic review. (2023)
Federal Grants 2
Research Interests
Research Interests: Promotion of patient-centered, evidence based endocrine care through a research program focusing on outcome analysis, evidence synthesis, decision making, and health services delivery. Main focus: subclinical hypothyroidism.
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Role of Natural Antibodies Against Oxidation Specific Epitopes in Bone Homeostasis VA Biomedical Laboratory Research and Development Merit Review Award Co-Investigator
- Subclinical hypothyroidism: a research career development plan Arkansas Biosciences Institute Principal Investigator
- Correlation of Bone Mineral Density with Anti-oxidation Specific Epitopes (anti-OSEs) Antibody levels South Central VA Health Care Network Principal Investigator
Collaboration Network
Top Collaborators
- Levothyroxine Use in the United States, 2008-2018
- Benefits and Harms of Levothyroxine/L-Triiodothyronine Versus Levothyroxine Monotherapy for Adult Patients with Hypothyroidism: Systematic Review and Meta-Analysis
- Appropriate Use of Telehealth Visits in Endocrinology: Policy Perspective of the Endocrine Society
- Inappropriate use of thyroid ultrasound: a systematic review and meta-analysis
- Effect of metformin on microvascular outcomes in patients with type 2 diabetes: A systematic review and meta-analysis
Showing 5 of 17 shared publications
- Benefits and Harms of Levothyroxine/L-Triiodothyronine Versus Levothyroxine Monotherapy for Adult Patients with Hypothyroidism: Systematic Review and Meta-Analysis
- Inappropriate use of thyroid ultrasound: a systematic review and meta-analysis
- Effect of metformin on microvascular outcomes in patients with type 2 diabetes: A systematic review and meta-analysis
- Treatment burden and perceptions of glucose-lowering therapy among people living with diabetes
- De-implementing low-value care in endocrinology
Showing 5 of 8 shared publications
- Ultrasound Image Classification of Thyroid Nodules Using Machine Learning Techniques
- Development and pilot testing of a conversation aid to support the evaluation of patients with thyroid nodules
- Clinician Agreement on the Classification of Thyroid Nodules Ultrasound Features: A Survey of 2 Endocrine Societies
- Interventions to improve symptomatology in patients with hypothyroidism and persistent symptoms: A systematic review
- Determinants for Thyroid Hormone Replacement Therapy in Subclinical Hypothyroidism: A Multicenter Electronic Health Records-Based Study
Showing 5 of 8 shared publications
- Benefits and Harms of Levothyroxine/L-Triiodothyronine Versus Levothyroxine Monotherapy for Adult Patients with Hypothyroidism: Systematic Review and Meta-Analysis
- Effect of metformin on microvascular outcomes in patients with type 2 diabetes: A systematic review and meta-analysis
- Treatment burden and perceptions of glucose-lowering therapy among people living with diabetes
- Determinants for Thyroid Hormone Replacement Therapy in Subclinical Hypothyroidism: A Multicenter Electronic Health Records-Based Study
- Intensive vs. conventional blood pressure goals in older patients with type 2 diabetes: a systematic review and meta-analysis
- Association of Thyroid Function with Suicidal Behavior: A Systematic Review and Meta-Analysis
- Determinants for Thyroid Hormone Replacement Therapy in Subclinical Hypothyroidism: A Multicenter Electronic Health Records-Based Study
- Isolated Maternal Hypothyroxinemia Is Associated with Preterm Delivery
- Frequency and Determinants of Levothyroxine Therapy Initiation for Veterans with Subclinical Hypothyroidism
- Pregnancy and Neonatal Outcomes With Levothyroxine Treatment in Women With Subclinical Hypothyroidism Based on New Diagnostic Criteria: A Systematic Review and Meta-Analysis
- Associations between Human Chorionic Gonadotropin, Maternal Free Thyroxine, and Gestational Diabetes Mellitus
- Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis
- Risk Factors for Thyroid Function Test Abnormalities During Pregnancy: A Systematic Review of the Literature to Validate Current Risk Factors and Identify Novel Ones
- Benefits and Harms of Levothyroxine/L-Triiodothyronine Versus Levothyroxine Monotherapy for Adult Patients with Hypothyroidism: Systematic Review and Meta-Analysis
- Effect of metformin on microvascular outcomes in patients with type 2 diabetes: A systematic review and meta-analysis
- Treatment burden and perceptions of glucose-lowering therapy among people living with diabetes
- Intensive vs. conventional blood pressure goals in older patients with type 2 diabetes: a systematic review and meta-analysis
- Appropriateness of Levothyroxine Prescription: A Multicenter Retrospective Study
- Interventions to improve symptomatology in patients with hypothyroidism and persistent symptoms: A systematic review
- Individualized Graves’ disease remission rates conversations: a videographic analysis of medical encounters
- Interventions to improve symptomatology in patients with hypothyroidism and persistent symptoms: A systematic review.
- Stopping Levothyroxine Therapy in Subclinical Hypothyroidism, Perhaps We Could Start a Trend
- Iron Deficiency Is Associated with Maternal Hypothyroxinemia in the Third Trimester of Pregnancy
- Thyroid Function Classification in Early Pregnancy Varies Considerably Across Repeated Testing Within an Interval of a Few Weeks
- Association of Thyroid Function with Suicidal Behavior: A Systematic Review and Meta-Analysis
- A novel MEN1 gene mutation associated with a pancreatic neuroendocrine tumor co-producing insulin and vasoactive intestinal polypeptide
- Association of Thyroid Function With Suicide Ideation/Attempt -A Systematic Review and Meta-analysis
- Association of Thyroid Function with Suicidal Behavior: A Systematic Review and Meta-Analysis
- Frequency and Determinants of Levothyroxine Therapy Initiation for Veterans with Subclinical Hypothyroidism
- Association of Thyroid Function With Suicide Ideation/Attempt -A Systematic Review and Meta-analysis
- Levothyroxine Use in the United States, 2008-2018
- Determinants for Thyroid Hormone Replacement Therapy in Subclinical Hypothyroidism: A Multicenter Electronic Health Records-Based Study
- Individualized Graves’ disease remission rates conversations: a videographic analysis of medical encounters
- Inappropriate use of thyroid ultrasound: a systematic review and meta-analysis
- Interventions to improve symptomatology in patients with hypothyroidism and persistent symptoms: A systematic review
- Interventions to improve symptomatology in patients with hypothyroidism and persistent symptoms: A systematic review.
- TSH and FT4 Reference Intervals in Pregnancy: A Systematic Review and Individual Participant Data Meta-Analysis
- Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy: An Individual Participant Data Meta-Analysis
- Risk Factors for Thyroid Function Test Abnormalities During Pregnancy: A Systematic Review of the Literature to Validate Current Risk Factors and Identify Novel Ones
- TSH and FT4 Reference Intervals in Pregnancy: A Systematic Review and Individual Participant Data Meta-Analysis
- Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy: An Individual Participant Data Meta-Analysis
- Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis
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