Spyridoula Maraka
Associate Professor
faculty
Internal Med, College of Medicine
Research Areas
Biography and Research Information
OverviewAI-generated summary
Spyridoula Maraka's research program focuses on patient-centered, evidence-based endocrine care, with a particular emphasis on subclinical hypothyroidism. Her work involves outcome analysis, evidence synthesis, decision-making processes, and health services delivery.
Her recent publications investigate the association between maternal thyroid function and pregnancy outcomes, including gestational hypertension and pre-eclampsia. She has also conducted systematic reviews and meta-analyses on levothyroxine use in the United States, the benefits and harms of different levothyroxine treatment regimens, and reference intervals for thyroid-stimulating hormone (TSH) and free thyroxine (FT4) during pregnancy. Other research areas include the association of thyroid function with suicidal behavior and the use of machine learning techniques for thyroid nodule classification.
Maraka is recognized as a highly cited researcher, with an h-index of 33 and 3,909 total citations across 137 publications. She leads a research group and collaborates with colleagues at the University of Arkansas for Medical Sciences, including Arwa Albashaireh, Richard R. Owen, Hooman Motahari, and Soumya Thumma.
Research Overview
Clinical Practice: General endocrinology with emphasis on thyroid disorders Research Interests: Promotion of patient-centered, evidence based endocrine care through a research program focusing on outcome analysis, evidence synthesis, decision making, and health services delivery. Main focus: subclinical hypothyroidism.
Metrics
- h-index: 32
- Publications: 136
- Citations: 3,913
Selected Publications
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A comparison of bilateral internal jugular vein sampling with bilateral inferior petrosal sinus sampling at Mayo Clinic for the subtype evaluation of corticotropin-dependent cushing syndrome (2025)
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Risk Factors for Thyroid Function Test Abnormalities During Pregnancy: A Systematic Review of the Literature to Validate Current Risk Factors and Identify Novel Ones (2025)
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Frequency and Determinants of Levothyroxine Therapy Initiation for Veterans with Subclinical Hypothyroidism (2024)
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Interventions to improve symptomatology in patients with hypothyroidism and persistent symptoms: A systematic review (2024)
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Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis (2024)
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Thyroid storm in pregnancy: a review (2024)
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Trends and Components of Thyroid Status Evaluation in Commercially Insured Adults in the United States, 2006-2020 (2023)
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Interventions to improve symptomatology in patients with hypothyroidism and persistent symptoms: A systematic review. (2023)
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Appropriateness of Levothyroxine Prescription: A Multicenter Retrospective Study (2023)
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Determinants for Thyroid Hormone Replacement Therapy in Subclinical Hypothyroidism: A Multicenter Electronic Health Records-Based Study (2023)
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Thyroid Cancer Risk Communication in Patients with Thyroid Nodules (2023)
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Appropriate Use of Telehealth Visits in Endocrinology: Policy Perspective of the Endocrine Society (2022)
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Intensive vs. conventional blood pressure goals in older patients with type 2 diabetes: a systematic review and meta-analysis (2022)
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TSH and FT4 Reference Intervals in Pregnancy: A Systematic Review and Individual Participant Data Meta-Analysis (2022)
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Under and overtreatment with thyroid hormone replacement during pregnancy (2022)
Research Interests
Research Interests: Promotion of patient-centered, evidence based endocrine care through a research program focusing on outcome analysis, evidence synthesis, decision making, and health services delivery. Main focus: subclinical hypothyroidism.
Grants & Funding
- Role of Natural Antibodies Against Oxidation Specific Epitopes in Bone Homeostasis VA Biomedical Laboratory Research and Development Merit Review Award Co-Investigator
- Discontinuation of levothyroxine therapy for patients with subclinical hypothyroidism: a pilot randomized, double-blinded, placebo-controlled study VA Health Services Research and Development Service Pilot Merit Review Award Principal Investigator
- Subclinical hypothyroidism: a research career development plan Arkansas Biosciences Institute Principal Investigator
- Correlation of Bone Mineral Density with Anti-oxidation Specific Epitopes (anti-OSEs) Antibody levels South Central VA Health Care Network Principal Investigator
Collaboration Network
Top Collaborators
- Levothyroxine Use in the United States, 2008-2018
- Benefits and Harms of Levothyroxine/L-Triiodothyronine Versus Levothyroxine Monotherapy for Adult Patients with Hypothyroidism: Systematic Review and Meta-Analysis
- Appropriate Use of Telehealth Visits in Endocrinology: Policy Perspective of the Endocrine Society
- Inappropriate use of thyroid ultrasound: a systematic review and meta-analysis
- Effect of metformin on microvascular outcomes in patients with type 2 diabetes: A systematic review and meta-analysis
Showing 5 of 19 shared publications
- Ultrasound Image Classification of Thyroid Nodules Using Machine Learning Techniques
- Development and pilot testing of a conversation aid to support the evaluation of patients with thyroid nodules
- Clinician Agreement on the Classification of Thyroid Nodules Ultrasound Features: A Survey of 2 Endocrine Societies
- Interventions to improve symptomatology in patients with hypothyroidism and persistent symptoms: A systematic review
- Determinants for Thyroid Hormone Replacement Therapy in Subclinical Hypothyroidism: A Multicenter Electronic Health Records-Based Study
Showing 5 of 10 shared publications
- Benefits and Harms of Levothyroxine/L-Triiodothyronine Versus Levothyroxine Monotherapy for Adult Patients with Hypothyroidism: Systematic Review and Meta-Analysis
- Inappropriate use of thyroid ultrasound: a systematic review and meta-analysis
- Effect of metformin on microvascular outcomes in patients with type 2 diabetes: A systematic review and meta-analysis
- Treatment burden and perceptions of glucose-lowering therapy among people living with diabetes
- De-implementing low-value care in endocrinology
Showing 5 of 8 shared publications
- Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia:a systematic review and individual-participant data meta-analysis
- Association of Thyroid Function with Suicidal Behavior: A Systematic Review and Meta-Analysis
- Determinants for Thyroid Hormone Replacement Therapy in Subclinical Hypothyroidism: A Multicenter Electronic Health Records-Based Study
- A Predictive Model for Graves’ Disease Recurrence After Antithyroid Drug Therapy: A Retrospective Multicenter Cohort Study
- Isolated Maternal Hypothyroxinemia Is Associated with Preterm Delivery
Showing 5 of 7 shared publications
- Benefits and Harms of Levothyroxine/L-Triiodothyronine Versus Levothyroxine Monotherapy for Adult Patients with Hypothyroidism: Systematic Review and Meta-Analysis
- Effect of metformin on microvascular outcomes in patients with type 2 diabetes: A systematic review and meta-analysis
- Treatment burden and perceptions of glucose-lowering therapy among people living with diabetes
- Determinants for Thyroid Hormone Replacement Therapy in Subclinical Hypothyroidism: A Multicenter Electronic Health Records-Based Study
- Intensive vs. conventional blood pressure goals in older patients with type 2 diabetes: a systematic review and meta-analysis
- Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia:a systematic review and individual-participant data meta-analysis
- TSH and FT4 Reference Intervals in Pregnancy: A Systematic Review and Individual Participant Data Meta-Analysis
- Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy: An Individual Participant Data Meta-Analysis
- Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis
- Association of gestational thyroid function and thyroid autoimmunity with gestational diabetes: a systematic review and individual participant meta-analysis
- Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia:a systematic review and individual-participant data meta-analysis
- TSH and FT4 Reference Intervals in Pregnancy: A Systematic Review and Individual Participant Data Meta-Analysis
- Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy: An Individual Participant Data Meta-Analysis
- Association of gestational thyroid function and thyroid autoimmunity with gestational diabetes: a systematic review and individual participant meta-analysis
- Risk Factors for Thyroid Function Test Abnormalities During Pregnancy: A Systematic Review of the Literature to Validate Current Risk Factors and Identify Novel Ones
- Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia:a systematic review and individual-participant data meta-analysis
- TSH and FT4 Reference Intervals in Pregnancy: A Systematic Review and Individual Participant Data Meta-Analysis
- Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy: An Individual Participant Data Meta-Analysis
- Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis
- Association of gestational thyroid function and thyroid autoimmunity with gestational diabetes: a systematic review and individual participant meta-analysis
- Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia:a systematic review and individual-participant data meta-analysis
- TSH and FT4 Reference Intervals in Pregnancy: A Systematic Review and Individual Participant Data Meta-Analysis
- Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy: An Individual Participant Data Meta-Analysis
- Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis
- Association of gestational thyroid function and thyroid autoimmunity with gestational diabetes: a systematic review and individual participant meta-analysis
- Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia:a systematic review and individual-participant data meta-analysis
- TSH and FT4 Reference Intervals in Pregnancy: A Systematic Review and Individual Participant Data Meta-Analysis
- Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy: An Individual Participant Data Meta-Analysis
- Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis
- Association of gestational thyroid function and thyroid autoimmunity with gestational diabetes: a systematic review and individual participant meta-analysis
- Pregnancy and Neonatal Outcomes With Levothyroxine Treatment in Women With Subclinical Hypothyroidism Based on New Diagnostic Criteria: A Systematic Review and Meta-Analysis
- Associations between Human Chorionic Gonadotropin, Maternal Free Thyroxine, and Gestational Diabetes Mellitus
- Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis
- Risk Factors for Thyroid Function Test Abnormalities During Pregnancy: A Systematic Review of the Literature to Validate Current Risk Factors and Identify Novel Ones
- Discontinuation of levothyroxine therapy in patients with subclinical hypothyroidism: a pilot randomized clinical trial
- Stopping Levothyroxine Therapy in Subclinical Hypothyroidism, Perhaps We Could Start a Trend
- Iron Deficiency Is Associated with Maternal Hypothyroxinemia in the Third Trimester of Pregnancy
- Thyroid Function Classification in Early Pregnancy Varies Considerably Across Repeated Testing Within an Interval of a Few Weeks
- Association of Thyroid Function with Suicidal Behavior: A Systematic Review and Meta-Analysis
- Frequency and Determinants of Levothyroxine Therapy Initiation for Veterans with Subclinical Hypothyroidism
- Discontinuation of levothyroxine therapy in patients with subclinical hypothyroidism: a pilot randomized clinical trial
- Association of Thyroid Function With Suicide Ideation/Attempt -A Systematic Review and Meta-analysis
- Levothyroxine Use in the United States, 2008-2018
- Determinants for Thyroid Hormone Replacement Therapy in Subclinical Hypothyroidism: A Multicenter Electronic Health Records-Based Study
- A Predictive Model for Graves’ Disease Recurrence After Antithyroid Drug Therapy: A Retrospective Multicenter Cohort Study
- Individualized Graves’ disease remission rates conversations: a videographic analysis of medical encounters
- Inappropriate use of thyroid ultrasound: a systematic review and meta-analysis
- Interventions to improve symptomatology in patients with hypothyroidism and persistent symptoms: A systematic review
- A Predictive Model for Graves’ Disease Recurrence After Antithyroid Drug Therapy: A Retrospective Multicenter Cohort Study
- Interventions to improve symptomatology in patients with hypothyroidism and persistent symptoms: A systematic review.
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