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Institution-verified
Presence
Current · Arkansas
Last published
2026
Sources
Institutional record
Refreshed
2026-10-09
E
Elena Ambrogini
Sourced from institutional research profiles (UAMS TRI or ARA).
Federal Grant PI
High Impact
Associate Professor
Also affiliated: University of Pisa (2002–2009); United States Department of Veterans Affairs (2024); University of Arkansas Medical Center (2024); Veterans Health Administration (2024); Central Arkansas Veterans Healthcare System (2009–2026); John L. McClellan Memorial Veterans Hospital (2024); Azienda Ospedaliera Universitaria Pisana (2005)
26 h-index
144 pubs
4,108 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Elena Ambrogini's research focuses on the molecular mechanisms underlying bone health and disease, particularly investigating the roles of oxidative stress and hormonal signaling in skeletal homeostasis. Her work has explored the impact of factors such as glucocorticoids, tumor necrosis factor α, and estrogen receptor-α on osteoblasts and osteoclasts.
Ambrogini has led investigations into the protective effects of FoxO-mediated defense against oxidative stress in osteoblasts, which has been shown to be indispensable for skeletal homeostasis in mice. Her research also examines how increased lipid oxidation contributes to oxidative stress and diminishes Wnt protein signaling in the skeleton. She received federal funding from the NIH for her project "Antibodies against Oxidized Phospholipids and Osteoporosis," serving as the Principal Investigator.
With an h-index of 26 and over 4,100 citations from 144 publications, Ambrogini is recognized as a highly cited researcher. She has a history of collaboration with researchers at the University of Arkansas for Medical Sciences, including Japneet Kaur, Aric Anloague, Sharmin Khan, and Charles A. O’Brien, with whom she shares numerous publications. Ambrogini leads a research group and has recently been active in research.
Metrics
- h-index: 26
- Publications: 144
- Citations: 4,108
Positions
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Associate Professor 2023–presentUniversity of Arkansas for Medical Sciences Orthopedics and Rehabilitation Institutional directory
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Director of the Division of Endocrinology and Metabolism 2021–presentUniversity of Arkansas for Medical Sciences Internal medicine ORCID
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Staff Endocrinologist (part time appointment) 2021–presentCentral Arkansas Veterans Healthcare System Internal medicine- Endocrinology ORCID
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Staff Endocrinologist (full time appointment) 2015–2021Central Arkansas Veterans Healthcare System Internal medicine ORCID
Selected Publications
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Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
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Additional file 1 of Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
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Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
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Additional file 1 of Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
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Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
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Deletion of the scavenger receptor Scarb1 in osteoblast progenitors and myeloid cells does not affect bone mass (2025)
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Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition (2025)
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Discontinuation of levothyroxine therapy in patients with subclinical hypothyroidism: a pilot randomized clinical trial (2025)
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Deletion of the scavenger receptor Scarb1 in osteoblast progenitors and myeloid cells does not affect bone mass (2025)
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Abstract 5099: Notch inhibition as a therapeutic approach to eliminate dormant cancer cells in multiple myeloma (2025)
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Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans (2025)
Federal Grants 1
VA
Contact PI
Oct 2019 - Dec 2027
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Center for Musculoskeletal Disease Research (CMDR) NIH/Nat. Inst. of General Medical Sciences
- Antibodies against oxidation-specific epitopes have an anabolic effect in murine bone Barton Endowment individual pilot study
- Antibodies against oxidation specific epitopes affect glucose metabolism UAMS Tobacco Funds and Translational Research Institute
- Role of subchondral bone osteocytes in post-traumatic osteoarthritis US Department of Defense
- Role of Natural Antibodies Against Oxidation Specific Epitopes in Bone Homeostasis NIH
- Atherosclerosis, osteoporosis, and innate immunity: a research career development plan UAMS Tobacco Funds and Translational Research Institute
Collaboration Network
Top Collaborators
Maria Almeida
Central Arkansas Veterans Healthcare System
15 shared publications
In database
- FoxO-Mediated Defense against Oxidative Stress in Osteoblasts Is Indispensable for Skeletal Homeostasis in Mice
- The Estrogen Receptor-α in Osteoclasts Mediates the Protective Effects of Estrogens on Cancellous But Not Cortical Bone
- Glucocorticoids and Tumor Necrosis Factor α Increase Oxidative Stress and Suppress Wnt Protein Signaling in Osteoblasts
- FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation
- Increased Lipid Oxidation Causes Oxidative Stress, Increased Peroxisome Proliferator-activated Receptor-γ Expression, and Diminished Pro-osteogenic Wnt Signaling in the Skeleton
Showing 5 of 15 shared publications
Stavros C. Manolagas
University of Arkansas for Medical Sciences
15 shared publications
In database
- The Estrogen Receptor-α in Osteoclasts Mediates the Protective Effects of Estrogens on Cancellous But Not Cortical Bone
- Glucocorticoids and Tumor Necrosis Factor α Increase Oxidative Stress and Suppress Wnt Protein Signaling in Osteoblasts
- Increased Lipid Oxidation Causes Oxidative Stress, Increased Peroxisome Proliferator-activated Receptor-γ Expression, and Diminished Pro-osteogenic Wnt Signaling in the Skeleton
- FOXOs attenuate bone formation by suppressing Wnt signaling
- Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERα
Showing 5 of 15 shared publications
Charles A. O’Brien
Central Arkansas Veterans Healthcare System
15 shared publications
In database
- FoxO-Mediated Defense against Oxidative Stress in Osteoblasts Is Indispensable for Skeletal Homeostasis in Mice
- The Estrogen Receptor-α in Osteoclasts Mediates the Protective Effects of Estrogens on Cancellous But Not Cortical Bone
- FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation
- Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual
- FOXOs attenuate bone formation by suppressing Wnt signaling
Showing 5 of 15 shared publications
Michela Palmieri
Central Arkansas Veterans Healthcare System
14 shared publications
In database
- Reduced osteoprotegerin expression by osteocytes may contribute to rebound resorption after denosumab discontinuation
- Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice
- A Neutralizing Antibody Targeting Oxidized Phospholipids Promotes Bone Anabolism in Chow-Fed Young Adult Mice
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
- Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis
Showing 5 of 14 shared publications
Robert L. Jilka
University of Arkansas for Medical Sciences
13 shared publications
In database
- FoxO-Mediated Defense against Oxidative Stress in Osteoblasts Is Indispensable for Skeletal Homeostasis in Mice
- The Estrogen Receptor-α in Osteoclasts Mediates the Protective Effects of Estrogens on Cancellous But Not Cortical Bone
- FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation
- Increased Lipid Oxidation Causes Oxidative Stress, Increased Peroxisome Proliferator-activated Receptor-γ Expression, and Diminished Pro-osteogenic Wnt Signaling in the Skeleton
- Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual
Showing 5 of 13 shared publications
Hayley M. Sabol
University of Arkansas for Medical Sciences
11 shared publications
In database
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
- A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma
- Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis
- Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition
- Senolytics deplete senescent osteocytes and improve bone health in metastatic breast cancer
Showing 5 of 11 shared publications
Aric Anloague
University of Arkansas for Medical Sciences
11 shared publications
In database
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
- A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma
- Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis
- Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition
- Senolytics deplete senescent osteocytes and improve bone health in metastatic breast cancer
Showing 5 of 11 shared publications
Jesús Delgado‐Calle
University of Arkansas for Medical Sciences
10 shared publications
In database
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
- A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma
- Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis
- Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition
- Senolytics deplete senescent osteocytes and improve bone health in metastatic breast cancer
Showing 5 of 10 shared publications
Robert S. Weinstein
Central Arkansas Veterans Healthcare System (US)
9 shared publications
- FoxO-Mediated Defense against Oxidative Stress in Osteoblasts Is Indispensable for Skeletal Homeostasis in Mice
- The Estrogen Receptor-α in Osteoclasts Mediates the Protective Effects of Estrogens on Cancellous But Not Cortical Bone
- Glucocorticoids and Tumor Necrosis Factor α Increase Oxidative Stress and Suppress Wnt Protein Signaling in Osteoblasts
- FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation
- Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual
Showing 5 of 9 shared publications
Ha‐Neui Kim
University of Arkansas for Medical Sciences
9 shared publications
In database
- FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation
- Increased marrow adipogenesis does not contribute to age‐dependent appendicular bone loss in female mice
- A Neutralizing Antibody Targeting Oxidized Phospholipids Promotes Bone Anabolism in Chow-Fed Young Adult Mice
- RETRACTED: Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass
- Deletion of the Scavenger Receptor Scarb1 in Myeloid Cells Does Not Affect Bone Mass
Showing 5 of 9 shared publications
Horacio Gómez-Acevedo
University of Arkansas for Medical Sciences
8 shared publications
In database
- Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice
- A Neutralizing Antibody Targeting Oxidized Phospholipids Promotes Bone Anabolism in Chow-Fed Young Adult Mice
- Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass
- RETRACTED: Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass
- Deletion of the Scavenger Receptor Scarb1 in Myeloid Cells Does Not Affect Bone Mass
Showing 5 of 8 shared publications
Carolina Schinke
University of Arkansas for Medical Sciences
8 shared publications
In database
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
- A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma
- Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition
- Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells
- Additional file 1 of Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells
Showing 5 of 8 shared publications
Han Li
Central Arkansas Veterans Healthcare System (US)
7 shared publications
- FoxO-Mediated Defense against Oxidative Stress in Osteoblasts Is Indispensable for Skeletal Homeostasis in Mice
- The Estrogen Receptor-α in Osteoclasts Mediates the Protective Effects of Estrogens on Cancellous But Not Cortical Bone
- Glucocorticoids and Tumor Necrosis Factor α Increase Oxidative Stress and Suppress Wnt Protein Signaling in Osteoblasts
- FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation
- Increased Lipid Oxidation Causes Oxidative Stress, Increased Peroxisome Proliferator-activated Receptor-γ Expression, and Diminished Pro-osteogenic Wnt Signaling in the Skeleton
Showing 5 of 7 shared publications
Stavros C. Manolagas
University of Arkansas for Medical Sciences
7 shared publications
In database
- FoxO-Mediated Defense against Oxidative Stress in Osteoblasts Is Indispensable for Skeletal Homeostasis in Mice
- FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation
- Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual
- Oxidative Stress Stimulates Apoptosis and Activates NF-κB in Osteoblastic Cells via a PKCβ/p66shc Signaling Cascade: Counter Regulation by Estrogens or Androgens
- Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans
Showing 5 of 7 shared publications
Intawat Nookaew
Winthrop Rockefeller Foundation
7 shared publications
In database
- Reduced osteoprotegerin expression by osteocytes may contribute to rebound resorption after denosumab discontinuation
- Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
- Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis
- Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition
Showing 5 of 7 shared publications
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