Elena Ambrogini

Sourced from institutional research profiles (UAMS TRI or ARA).

Federal Grant PI High Impact

Associate Professor

UAMS

Also affiliated: University of Pisa (2002–2009); United States Nuclear Regulatory Commission (2003); Central Arkansas Veterans Healthcare System (2009–2026); Max Planck Institute for Metabolism Research (2007); John L. McClellan Memorial Veterans Hospital (2024); Azienda Ospedaliera Universitaria Pisana (2005)

Faculty Researcher

26 h-index 141 pubs 4,058 cited

Research Areas

Biomedical Subjects

Links

ORCID Research Group UAMS TRI Profile

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OverviewAI-generated summary

Elena Ambrogini's research focuses on the mechanisms underlying bone loss and the cellular changes associated with aging and disease. Her work investigates the role of specific molecular signaling pathways and cell types, such as osteocytes and senescent cells, in contributing to conditions like age-related bone loss, post-denosumab rebound resorption, and bone destruction in the context of breast cancer metastasis and multiple myeloma.

Her recent publications explore the impact of reduced osteoprotegerin expression on bone resorption, the protective effects of neutralizing oxidized phospholipids against age-associated bone loss in mice, and the function of Piezo1 in opposing cortical bone loss. Ambrogini has also investigated the role of senescent osteocytes in triggering bone destruction in breast cancer metastasis and identified novel signaling axes, including NOTCH3-CXCL12 and CCL3-HMGB1, that regulate osteocyte activity in multiple myeloma.

Ambrogini leads a research group and has a significant publication record, with 141 total publications and over 4,000 citations, reflected in her h-index of 26. She is recognized as a highly cited researcher and collaborates extensively with colleagues at the University of Arkansas for Medical Sciences, including Charles A. O’Brien, Hayley M. Sabol, Japneet Kaur, and Aric Anloague.

Metrics

h-index: 26
Publications: 141
Citations: 4,058

Selected Publications

Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)

Figshare DOI OpenAlex
Additional file 1 of Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)

Figshare DOI OpenAlex
Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)

Figshare DOI OpenAlex
Additional file 1 of Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)

Open MIND DOI OpenAlex
Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)

Journal of Experimental & Clinical Cancer Research DOI OpenAlex
Deletion of the scavenger receptor Scarb1 in osteoblast progenitors and myeloid cells does not affect bone mass (2025)

PLoS ONE DOI OpenAlex
Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition (2025)

Experimental Hematology and Oncology 3 citations DOI OpenAlex
Discontinuation of levothyroxine therapy in patients with subclinical hypothyroidism: a pilot randomized clinical trial (2025)

Endocrine 7 citations DOI OpenAlex
Deletion of the scavenger receptor <i>Scarb1</i> in osteoblast progenitors and myeloid cells does not affect bone mass (2025)

bioRxiv (Cold Spring Harbor Laboratory) DOI OpenAlex
Abstract 5099: Notch inhibition as a therapeutic approach to eliminate dormant cancer cells in multiple myeloma (2025)

Cancer Research DOI OpenAlex
Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans (2025)

Scientific Reports 1 citation DOI OpenAlex

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Federal Grants 1

VA Contact PI Oct 2019 - Dec 2027

Antibodies against Oxidized Phospholipids and Osteoporosis

Administered by Central Arkansas Veterans Healthcare System I01

Grants & Funding

As listed on this researcher's institutional profile. Federal awards with verified records are shown above.

Center for Musculoskeletal Disease Research (CMDR) NIH/Nat. Inst. of General Medical Sciences
Antibodies against oxidation-specific epitopes have an anabolic effect in murine bone Barton Endowment individual pilot study
Antibodies against oxidation specific epitopes affect glucose metabolism UAMS Tobacco Funds and Translational Research Institute
Role of subchondral bone osteocytes in post-traumatic osteoarthritis US Department of Defense
Role of Natural Antibodies Against Oxidation Specific Epitopes in Bone Homeostasis NIH
Atherosclerosis, osteoporosis, and innate immunity: a research career development plan UAMS Tobacco Funds and Translational Research Institute