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Presence Current · Arkansas
Last published 2026
Sources OpenAlex · ORCID
Refreshed 2026-10-01

Todd J. Spears

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1 h-index 4 pubs 29 cited

  • Pyroptosis
  • Bacterial Infections
  • Humans
  • Macrophages
  • Neutrophils
  • Gram-Negative Bacterial Infections
  • Inflammasomes
  • Cytidine Deaminase
  • DNA
  • Proto-Oncogene Proteins c-myc
  • Proto-Oncogene Proteins c-bcl-2
  • Animals
  • Epithelial Cells
  • Gram-Negative Bacteria
  • Immunity, Innate

Biography and Research Information

OverviewAI-generated summary

Todd J. Spears researches the mechanisms of host defense against pathogenic bacteria, with a particular focus on inflammasome-mediated pyroptosis. His work investigates how these cellular processes contribute to the immune system's response to bacterial infections. Spears has also explored the role of DNA secondary structures in gene regulation, specifically examining how these structures in genes like BCL2 and MYC can influence the binding and activity of cytidine deaminase. His earlier publications include work on the manipulation of apoptosis by ascoviruses for viral replication and transmission, indicating a broader interest in host-pathogen interactions and cellular death pathways.

Metrics

  • h-index: 1
  • Publications: 4
  • Citations: 29

Selected Publications

  • DNA secondary structures in BCL2 and MYC elicit activation-induced cytidine deaminase binding and activity (2026)
    Nucleic Acids Research 1 citation DOI OpenAlex
  • Inflammasome‐mediated pyroptosis in defense against pathogenic bacteria (2024)
    Immunological Reviews 28 citations DOI OpenAlex

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Collaboration Network

10 Collaborators 3 Institutions 1 Country

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