G-Quadruplexes

Researchers investigate G-quadruplexes, unique four-stranded DNA structures that form in guanine-rich regions of the genome. This work explores how these structures influence fundamental biological processes, including DNA replication, repair, and gene expression. Studies employ biophysical techniques to characterize G-quadruplex formation and stability, alongside molecular biology methods to assess their roles in cellular function and dysfunction. Specific areas of focus include understanding how G-quadruplexes interact with proteins, such as helicases and viral proteins, and their implications in disease states.

This research has relevance to Arkansas's public health sector by contributing to a deeper understanding of diseases where G-quadruplexes may play a role, such as cancer and viral infections. Insights gained can inform the development of novel therapeutic strategies. Furthermore, the study of nucleic acid structures is foundational to the biotechnology and pharmaceutical industries, sectors with growing potential in Arkansas, supporting innovation and economic development.

This area is highly interdisciplinary, drawing connections to molecular biology, biochemistry, genetics, and virology. Research efforts engage with related fields such as DNA repair mechanisms, DNA replication, and host-pathogen interactions, fostering a comprehensive approach to understanding these complex nucleic acid structures.