Osteogenesis Imperfecta

2 researchers across 1 institution

2 Researchers
1 Institutions
0 Grant PIs
0 High Impact

Research in osteogenesis imperfecta (OI) investigates the genetic and molecular mechanisms underlying this brittle bone disorder. Studies examine the structure and function of collagen, a key protein in bone, and how mutations in collagen genes lead to bone fragility. Investigations also explore cellular and animal models to understand disease progression and identify potential therapeutic targets. This work addresses fundamental questions about bone development, maintenance, and the impact of genetic defects on skeletal integrity.

This research has relevance to Arkansas by contributing to the understanding of genetic disorders that affect bone health, a critical component of public health. Improved knowledge of OI can inform clinical care and support for individuals and families affected by rare genetic conditions within the state. Furthermore, research into bone metabolism and genetic disorders can align with Arkansas's growing healthcare sector and its focus on improving health outcomes for its citizens.

This area connects with metabolism and genetic disorders, genomics, and disease models. Collaborations often involve expertise in bone metabolism, collagen biology, and animal research, fostering a multidisciplinary approach to understanding and treating OI.

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Top Researchers

Name Institution h-index Citations Career Stage Badges
Milena Dimori UAMS 10 353
Jordan Fett UAMS 3 31
Metabolism And Genetic Disorders 2 Disease Models, Animal 1 Collagen Type I 1 Asthma And Respiratory Diseases 1 Bone Metabolism And Diseases 1 Genomics And Rare Diseases 1 Animal, Disease Models 1 Respiratory Support And Mechanisms 1 Molecular Biology Techniques And Applications 1 Medical Case Reports 1 Ehlers-Danlos Syndrome 1

Strategic Outlook

Global signals from OpenAlex for this research area: where the field is growing, how concentrated leadership is, and where Arkansas sits relative to the world's top-100 institutions. Descriptive only — surfaced as input to the conversation about where to place bets, not a recommendation. Signal confidence: LOW

Global trajectory
4,433 works in 2026
+1.5% CAGR 2018–2026
Leadership concentration
4.5% held by global top 5 institutions
Fragmented HHI 15
Arkansas position
Arkansas not in global top 100
No AR institution among the top-100 contributors to this topic over the 2018–2026 window.

Top US institutions in this area

  1. 1 Johns Hopkins University 1,144
  2. 2 Harvard University 1,139
  3. 3 University of Washington 848
  4. 4 Washington University in St. Louis 815
  5. 5 University of Pennsylvania 781
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