Biography and Research Information

OverviewAI-generated summary

J. Leung's research investigates molecular mechanisms underlying cancer, with a focus on radioresistance and DNA damage response pathways. Their work includes the discovery of a novel driver of radioresistance in pancreatic cancer, identified through genome-wide RNA-sequencing. Leung has secured federal funding to lead studies on the chromatin-based DNA damage response pathway and the mechanistic characterization of cell cycle-dependent DNA repair pathways. Additionally, Leung is a co-PI on a grant examining RNA modifications by paternal exposure to arsenic and its intergenerational effects on sperm quality, funded by the NIH/National Institute of Environmental Health Sciences.

Collaborative efforts include work with Alan Tackett at the University of Arkansas for Medical Sciences, with whom Leung has shared publications. Leung maintains an active lab website to disseminate research findings.

Metrics

  • Publications: 1

Selected Publications

  • Discovery of a Novel Driver of Radioresistance in Pancreatic Cancer (PC) Using Genome-Wide RNA-Seq (2022) DOI

Federal Grants 3 $900,659 total

NIH/National Institute of Environmental Health Sciences Co-PI Apr 2022 - Jan 2027

RNA modifications by paternal exposure to arsenic and intergenerational effects on sperm quality

National Institute of Environmental Health Sciences $468,131 R01
NIH/National Cancer Institute Contact PI Mar 2021 - Dec 2022

Mechanistic characterization of the cell cycle-dependent DNA repair pathway- Resubmission

National Cancer Institute $52,528 R01
NIH/National Institute of General Medical Sciences Contact PI Sep 2020 - Aug 2025

Deciphering the chromatin-based DNA damage response pathway

National Institute of General Medical Sciences $380,000 R35

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