U Thaung Shwe
Researcher
Also affiliated: University of Freiburg (2011); Heidelberg University (2012); Universitätsklinikum des Saarlandes (2011); National Institute of Environmental Health Sciences (2011–2012); Health and Human Development (2HD) Research Network (2011); Saarland University (2011–2012)
Faculty Researcher
Research Areas
Biomedical Subjects
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Biography and Research Information
OverviewAI-generated summary
U Thaung Shwe's research investigates the role of canonical transient receptor potential (TRPC) channels in neurological disorders, particularly epilepsy. His work focuses on understanding how these ion channels contribute to neuronal hyperexcitability and cell death following seizures. Recent publications explore the function of TRPC3 channels in hippocampal excitability and seizure-induced neuronal damage, as well as the pharmacological differences between homomeric and heteromeric TRPC4 and TRPC1/4 channels in specific neurons. Shwe's studies also examine the impact of TRPC channel deficiencies, such as in TRPC1/4 double knockout mice, on susceptibility to pilocarpine-induced status epilepticus. His research collaborations include Fang Zheng at the University of Arkansas for Medical Sciences and Kevin D. Phelan at the University of Arkansas at Fayetteville, with whom he has co-authored multiple publications.
Metrics
- h-index: 6
- Publications: 8
- Citations: 414
Selected Publications
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Investigating Contributions of Canonical Transient Receptor Potential Channel 3 to Hippocampal Hyperexcitability and Seizure-Induced Neuronal Cell Death (2024)
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Increased Susceptibility to Pilocarpine-Induced Status Epilepticus and Reduced Latency in TRPC1/4 Double Knockout Mice (2023)
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Pharmacological Differences between Native Homomeric Transient Receptor Potential Canonical Type 4 Channels and Heteromeric Transient Receptor Potential Canonical Type 1/4 Channels in Lateral Septal Neurons (2023)
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<scp>TRPC</scp>3 channels play a critical role in the theta component of pilocarpine‐induced status epilepticus in mice (2016)
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Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale (2015)
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Critical role of canonical transient receptor potential channel 7 in initiation of seizures (2014)
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Canonical Transient Receptor Channel 5 (TRPC5) and TRPC1/4 Contribute to Seizure and Excitotoxicity by Distinct Cellular Mechanisms (2012)
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Heteromeric Canonical Transient Receptor Potential 1 and 4 Channels Play a Critical Role in Epileptiform Burst Firing and Seizure-Induced Neurodegeneration (2011)
Collaboration Network
Top Collaborators
- Pharmacological Differences between Native Homomeric Transient Receptor Potential Canonical Type 4 Channels and Heteromeric Transient Receptor Potential Canonical Type 1/4 Channels in Lateral Septal Neurons
- Investigating Contributions of Canonical Transient Receptor Potential Channel 3 to Hippocampal Hyperexcitability and Seizure-Induced Neuronal Cell Death
- Increased Susceptibility to Pilocarpine-Induced Status Epilepticus and Reduced Latency in TRPC1/4 Double Knockout Mice
- Pharmacological Differences between Native Homomeric Transient Receptor Potential Canonical Type 4 Channels and Heteromeric Transient Receptor Potential Canonical Type 1/4 Channels in Lateral Septal Neurons
- Investigating Contributions of Canonical Transient Receptor Potential Channel 3 to Hippocampal Hyperexcitability and Seizure-Induced Neuronal Cell Death
- Increased Susceptibility to Pilocarpine-Induced Status Epilepticus and Reduced Latency in TRPC1/4 Double Knockout Mice
- Investigating Contributions of Canonical Transient Receptor Potential Channel 3 to Hippocampal Hyperexcitability and Seizure-Induced Neuronal Cell Death
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