U Thaung Shwe

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UAMS

Also affiliated: National Institutes of Health (2012); University of Freiburg (2011); Heidelberg University (2012); National Institute of Environmental Health Sciences (2011–2012); Walther-Straub-Institut für Pharmakologie und Toxikologie (2011); Ludwig-Maximilians-Universität München (2011); Saarland University (2011–2012)

6 h-index 8 pubs 416 cited

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OverviewAI-generated summary

U Thaung Shwe's research investigates the role of canonical transient receptor potential (TRPC) channels in neurological disorders, particularly epilepsy. His work focuses on understanding how these ion channels contribute to neuronal hyperexcitability and cell death following seizures. Recent publications explore the function of TRPC3 channels in hippocampal excitability and seizure-induced neuronal damage, as well as the pharmacological differences between homomeric and heteromeric TRPC4 and TRPC1/4 channels in specific neurons. Shwe's studies also examine the impact of TRPC channel deficiencies, such as in TRPC1/4 double knockout mice, on susceptibility to pilocarpine-induced status epilepticus. His research collaborations include Fang Zheng at the University of Arkansas for Medical Sciences and Kevin D. Phelan at the University of Arkansas at Fayetteville, with whom he has co-authored multiple publications.

Metrics

h-index: 6
Publications: 8
Citations: 416

Selected Publications

Investigating Contributions of Canonical Transient Receptor Potential Channel 3 to Hippocampal Hyperexcitability and Seizure-Induced Neuronal Cell Death (2024)

International Journal of Molecular Sciences 8 citations DOI OpenAlex
Increased Susceptibility to Pilocarpine-Induced Status Epilepticus and Reduced Latency in TRPC1/4 Double Knockout Mice (2023)

Neurology International 1 citation DOI OpenAlex
Pharmacological Differences between Native Homomeric Transient Receptor Potential Canonical Type 4 Channels and Heteromeric Transient Receptor Potential Canonical Type 1/4 Channels in Lateral Septal Neurons (2023)

Pharmaceuticals 6 citations DOI OpenAlex
TRPC 3 channels play a critical role in the theta component of pilocarpine‐induced status epilepticus in mice (2016)

Epilepsia 37 citations DOI OpenAlex
Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale (2015)

Epilepsy Research 77 citations DOI OpenAlex
Critical role of canonical transient receptor potential channel 7 in initiation of seizures (2014)

Proceedings of the National Academy of Sciences 43 citations DOI OpenAlex
Canonical Transient Receptor Channel 5 (TRPC5) and TRPC1/4 Contribute to Seizure and Excitotoxicity by Distinct Cellular Mechanisms (2012)

Molecular Pharmacology 147 citations DOI OpenAlex
Heteromeric Canonical Transient Receptor Potential 1 and 4 Channels Play a Critical Role in Epileptiform Burst Firing and Seizure-Induced Neurodegeneration (2011)

Molecular Pharmacology 96 citations DOI OpenAlex