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Confirmed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-10-08
Kevin D. Phelan
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
High Impact
Professor
Also affiliated: National Institutes of Health (2012); University of Freiburg (2011); Heidelberg University (2012); University of Arkansas Medical Center (1997–2019); National Institute of Environmental Health Sciences (2011–2012); Walther-Straub-Institut für Pharmakologie und Toxikologie (2011); The University of Texas Medical Branch at Galveston (1989–1996); University of Pennsylvania (1992); Ludwig-Maximilians-Universität München (2011); Michigan State University (1982–1991); Saarland University (2011–2012)
Neurobiology & Developmental Science, College of Medicine
26 h-index
81 pubs
2,380 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Kevin D. Phelan is a professor in the Department of Neurobiology & Developmental Science at the University of Arkansas at Fayetteville. His research focuses on neurological disorders and treatments, particularly investigating the roles of ion channels in neuronal excitability and cell death. He has studied the canonical transient receptor potential (TRPC) channels, examining their contribution to hippocampal hyperexcitability and seizure-induced neuronal death, as well as their pharmacological differences in various neuronal populations.
Phelan's work also extends to neuroinflammation and metabolic pathways. He has investigated ethanol's modulation of cerebellar neuroinflammation in a mouse model of fetal alcohol spectrum disorders and explored the effects of liraglutide on endoplasmic reticulum stress in hypothalamic neurons. His research group has explored the localization of MC4R at synaptic sites of hypothalamic neurons. Phelan has secured federal funding for outreach programs aimed at exposing high school students to health and data science technologies, including the ArkanSONO program funded by the NIH/National Institute of General Medical Sciences for $266,590 and the AR Tech-DaSH program funded by the NIH/National Institute of Allergy and Infectious Diseases for $241,655.
With a career marked by active research, Phelan has published 86 works, accumulating over 2,350 citations and an h-index of 26. He collaborates with researchers at the University of Arkansas for Medical Sciences, including Noor Akhter, Mohsin Syed, Fang Zheng, and U Thaung Shwe, on multiple publications.
Metrics
- h-index: 26
- Publications: 81
- Citations: 2,380
Positions
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Professor publications 1996–2025University of Arkansas for Medical Sciences Neurobiology & Developmental Science, College of Medicine Institutional directory
Selected Publications
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Ultrasonographic determination of bifurcation site of the tibial nerve at the tarsal tunnel (2025)
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MC4R Localizes at Excitatory Postsynaptic and Peri-Postsynaptic Sites of Hypothalamic Neurons in Primary Culture (2024)
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Investigating Contributions of Canonical Transient Receptor Potential Channel 3 to Hippocampal Hyperexcitability and Seizure-Induced Neuronal Cell Death (2024)
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Increased Susceptibility to Pilocarpine-Induced Status Epilepticus and Reduced Latency in TRPC1/4 Double Knockout Mice (2023)
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Improved Confidence and Clinical Application: The Effects of a Longitudinal Suture Curriculum for Medical Students (2023)
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Pharmacological Differences between Native Homomeric Transient Receptor Potential Canonical Type 4 Channels and Heteromeric Transient Receptor Potential Canonical Type 1/4 Channels in Lateral Septal Neurons (2023)
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Bridging the Technology Divide in the COVID-19 Era: Using Virtual Outreach to Expose Middle and High School Students to Imaging Technology (2022)
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Liraglutide Counteracts Endoplasmic Reticulum Stress in Palmitate-Treated Hypothalamic Neurons without Restoring Mitochondrial Homeostasis (2022)
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Bridging the Technology Divide in the COVID-19 Era: Using Virtual Outreach to Expose Middle and High School Students to Imaging Technology (2022)
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Retroaortic Left Renal Vein: An Incidental Finding During Cadaver Dissection (2022)
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Development of an Innovative Learning Model for Dietetic Interns Utilizing Gross Anatomy Lab Resources (2021)
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Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders (2021)
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Selective Survival of Sim1/MC4R Neurons in Diet-Induced Obesity (2020)
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Delivery of phosphatidylethanolamine blunts stress in hepatoma cells exposed to elevated palmitate by targeting the endoplasmic reticulum (2020)
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Vascular smooth muscle TRPC3 channels facilitate the inverse hemodynamic response during status epilepticus (2020)
Federal Grants 2 $508,245 total
NIH
Contact PI
May 2024 - Mar 2025
AR Tech-DaSH: Arkansas Technology and Data Science in Health and Medicine
NIH
Contact PI
Aug 2018 - May 2024
ArkanSONO: A Technology Based Outreach Exposure Program for High School Students
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Lipid Stress and MC4R NIH Co-Investigator
- Dynamic neuroimmune interactions in the onset and progression of FASD NIH Co-Investigator
- MECHANISMS OF GABA-B INHIBITION AND EPILEPSY NIH Principal Investigator
- MHC CLASS I Expression and Function in Murine Cerebellum NIH/Nat. Inst. of Child Health & Human Development Principal Investigator
- Canonical Transient Receptor Potential Channels and Excitotoxicity NIH Co-Investigator
- METABOTROPIC GLUTAMATE RECEPTORS AND EXCITOTOXICITY NIH Co-Investigator
- The role of the endothelial NPYR1-TRPC3-ET1 signaling axis in neurovascular coupling dysfunction NIH Co-Investigator
- Microglia modulate ethanol impact on CNS development. NIH Co-Investigator
- Regulation of Neuroimmune Responses in FASD Models NIH Co-Investigator
- MHC CLASS I EXPRESSION AND FUNCTION IN MURINE CEREBELLUM NIH Principal Investigator
- Neuroinflammation: Role in FASD Cognitive Deficits NIH Co-Investigator
- ZINC-DEPENDENT APPARENT DESENSITIZATION OF NMDA RECEPTOR NIH Co-Investigator
Collaboration Network
Top Collaborators
Cynthia J.M. Kane
University of Arkansas for Medical Sciences
11 shared publications
In database
- Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders
- Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice
- Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists
- Effects of ethanol on immune response in the brain: region-specific changes in aged mice
- Neuroimmune mechanisms in fetal alcohol spectrum disorder
Showing 5 of 11 shared publications
Fang Zheng
University of Arkansas for Medical Sciences
10 shared publications
In database
- Canonical Transient Receptor Channel 5 (TRPC5) and TRPC1/4 Contribute to Seizure and Excitotoxicity by Distinct Cellular Mechanisms
- Heteromeric Canonical Transient Receptor Potential 1 and 4 Channels Play a Critical Role in Epileptiform Burst Firing and Seizure-Induced Neurodegeneration
- Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale
- The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity
- TRPC 3 channels play a critical role in the theta component of pilocarpine‐induced status epilepticus in mice
Showing 5 of 10 shared publications
Paul D. Drew
University of Arkansas for Medical Sciences
8 shared publications
In database
- Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders
- Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice
- Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists
- Effects of ethanol on immune response in the brain: region-specific changes in aged mice
- Neuroimmune mechanisms in fetal alcohol spectrum disorder
Showing 5 of 8 shared publications
Noor Akhter
University of Arkansas for Medical Sciences
7 shared publications
In database
- Medical gross anatomy: conversion of a traditional discipline‐based course to a briefer and more clinically focused foundational module in a revamped preclinical curriculum (532.1)
- Retroaortic Left Renal Vein: An Incidental Finding During Cadaver Dissection
- Bridging the Technology Divide in the COVID-19 Era: Using Virtual Outreach to Expose Middle and High School Students to Imaging Technology
- Multiple changes in teaching procedures increase student engagement and success in gross anatomy during revision of a medical curriculum
- Right to Left Crossed Fused Renal Ectopia: An Incidental Finding in Cadaveric Dissection
Showing 5 of 7 shared publications
Mohsin Syed
University of Arkansas for Medical Sciences
7 shared publications
In database
- Medical gross anatomy: conversion of a traditional discipline‐based course to a briefer and more clinically focused foundational module in a revamped preclinical curriculum (532.1)
- Retroaortic Left Renal Vein: An Incidental Finding During Cadaver Dissection
- Bridging the Technology Divide in the COVID-19 Era: Using Virtual Outreach to Expose Middle and High School Students to Imaging Technology
- Multiple changes in teaching procedures increase student engagement and success in gross anatomy during revision of a medical curriculum
- Right to Left Crossed Fused Renal Ectopia: An Incidental Finding in Cadaveric Dissection
Showing 5 of 7 shared publications
U Thaung Shwe
University of Arkansas for Medical Sciences
7 shared publications
In database
- Canonical Transient Receptor Channel 5 (TRPC5) and TRPC1/4 Contribute to Seizure and Excitotoxicity by Distinct Cellular Mechanisms
- Heteromeric Canonical Transient Receptor Potential 1 and 4 Channels Play a Critical Role in Epileptiform Burst Firing and Seizure-Induced Neurodegeneration
- Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale
- TRPC 3 channels play a critical role in the theta component of pilocarpine‐induced status epilepticus in mice
- Investigating Contributions of Canonical Transient Receptor Potential Channel 3 to Hippocampal Hyperexcitability and Seizure-Induced Neuronal Cell Death
Showing 5 of 7 shared publications
Giulia Baldini
University of Arkansas for Medical Sciences
7 shared publications
In database
- The melanocortin pathway and control of appetite-progress and therapeutic implications
- Delivery of phosphatidylethanolamine blunts stress in hepatoma cells exposed to elevated palmitate by targeting the endoplasmic reticulum
- Injury to hypothalamic Sim1 neurons is a common feature of obesity by exposure to high‐fat diet in male and female mice
- Selective Survival of Sim1/MC4R Neurons in Diet-Induced Obesity
- Liraglutide Counteracts Endoplasmic Reticulum Stress in Palmitate-Treated Hypothalamic Neurons without Restoring Mitochondrial Homeostasis
Showing 5 of 7 shared publications
James C. Douglas
University of Arkansas for Medical Sciences
6 shared publications
In database
- Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders
- Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice
- Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists
- Effects of ethanol on immune response in the brain: region-specific changes in aged mice
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
Showing 5 of 6 shared publications
David Lewis Davies
University of Arkansas for Medical Sciences
5 shared publications
In database
- Heterogeneity of astroglia cultured from adult human temporal lobe
- Medical gross anatomy: conversion of a traditional discipline‐based course to a briefer and more clinically focused foundational module in a revamped preclinical curriculum (532.1)
- Retroaortic Left Renal Vein: An Incidental Finding During Cadaver Dissection
- Multiple changes in teaching procedures increase student engagement and success in gross anatomy during revision of a medical curriculum
- Right to Left Crossed Fused Renal Ectopia: An Incidental Finding in Cadaveric Dissection
Haven Griffin
University of Arkansas for Medical Sciences
5 shared publications
In database
- Delivery of phosphatidylethanolamine blunts stress in hepatoma cells exposed to elevated palmitate by targeting the endoplasmic reticulum
- Selective Survival of Sim1/MC4R Neurons in Diet-Induced Obesity
- Liraglutide Counteracts Endoplasmic Reticulum Stress in Palmitate-Treated Hypothalamic Neurons without Restoring Mitochondrial Homeostasis
- MC4R Localizes at Excitatory Postsynaptic and Peri-Postsynaptic Sites of Hypothalamic Neurons in Primary Culture
- Obesity by High Fat Diet Decreases the Abundance of MC4R Protein in the Paraventricular Nucleus of the Hypothalamus without Reducing the Number of MC4R Neurons
Jason Y. Chang
University of Arkansas for Medical Sciences (US)
4 shared publications
- Neurotoxicity of 25-OH-Cholesterol on NGF-Differentiated PC12 Cells
- Neurotoxicity of 25-OH-Cholesterol on Sympathetic Neurons
- Transforming growth factor-?2 selectively alters the developmental expression of the fast transient A-current in cultured rat superior cervical ganglion neurons
- Establishment of Two Morphologically Distinct PC12 Cell Lines Resistant to 25-OH-Cholesterol Toxicity
Jennifer W. Johnson
University of Arkansas for Medical Sciences
4 shared publications
In database
- Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders
- Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice
- Effects of ethanol on immune response in the brain: region-specific changes in aged mice
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
Hong Wu
University of Arkansas for Medical Sciences (US)
4 shared publications
- Canonical Transient Receptor Channel 5 (TRPC5) and TRPC1/4 Contribute to Seizure and Excitotoxicity by Distinct Cellular Mechanisms
- TRPC 3 channels play a critical role in the theta component of pilocarpine‐induced status epilepticus in mice
- Vascular smooth muscle TRPC3 channels facilitate the inverse hemodynamic response during status epilepticus
- Investigating Contributions of Canonical Transient Receptor Potential Channel 3 to Hippocampal Hyperexcitability and Seizure-Induced Neuronal Cell Death
Lutz Birnbaumer
Pontificia Universidad Católica Argentina (AR)
4 shared publications
- Canonical Transient Receptor Channel 5 (TRPC5) and TRPC1/4 Contribute to Seizure and Excitotoxicity by Distinct Cellular Mechanisms
- Heteromeric Canonical Transient Receptor Potential 1 and 4 Channels Play a Critical Role in Epileptiform Burst Firing and Seizure-Induced Neurodegeneration
- TRPC 3 channels play a critical role in the theta component of pilocarpine‐induced status epilepticus in mice
- Vascular smooth muscle TRPC3 channels facilitate the inverse hemodynamic response during status epilepticus
Eugene Nyamugenda
University of Arkansas Medical Center (US)
4 shared publications
- Delivery of phosphatidylethanolamine blunts stress in hepatoma cells exposed to elevated palmitate by targeting the endoplasmic reticulum
- Injury to hypothalamic Sim1 neurons is a common feature of obesity by exposure to high‐fat diet in male and female mice
- Selective Survival of Sim1/MC4R Neurons in Diet-Induced Obesity
- Obesity by High Fat Diet Decreases the Abundance of MC4R Protein in the Paraventricular Nucleus of the Hypothalamus without Reducing the Number of MC4R Neurons
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