Fang Zheng
Professor
Also affiliated: National Institutes of Health (2012); State University of New York (2003); Emory University (1996–2003); Chiba University (2003); University of Freiburg (2011); National University of Singapore (2003); SUNY Downstate Health Sciences University (2003); Heidelberg University (2012); National Institute of Environmental Health Sciences (2011–2012); National Neuroscience Institute (2003); Walther-Straub-Institut für Pharmakologie und Toxikologie (2011); The University of Texas Medical Branch at Galveston (1991–1995); The University of Tokyo (2009); Ludwig-Maximilians-Universität München (2011); Saarland University (2011–2012)
Pharmacology & Toxicology, College of Medicine
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Fang Zheng's research focuses on understanding the molecular mechanisms underlying neurological disorders and the pharmacological interventions for these conditions. His work investigates the roles of ion channels, such as TRPC channels and NMDA receptors, in neuronal function and dysfunction. Zheng has received federal funding from the NIH/National Institute of Neurological Disorders and Stroke for a project examining the NPYR1-TRPC3-ET1 signaling axis in neurovascular coupling dysfunction.
His publications include studies on the control of NMDA receptor currents by zinc and protons, the contribution of TRPC5 and TRPC1/4 channels to seizures and excitotoxicity, and the development of selective muscarinic acetylcholine receptor antagonists for seizure reduction. Zheng also explores the impact of sleep deprivation on autophagy and apoptosis in hippocampal neurons, and the neuroprotective effects of modafinil. His work involves both animal models and human studies, contributing to the broader field of neuroscience and toxicology.
Metrics
- h-index: 20
- Publications: 40
- Citations: 1,988
Positions
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Professor publications 2003–2025University of Arkansas for Medical Sciences Pharmacology & Toxicology, College of Medicine Institutional directory
Selected Publications
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Increased luminal pressure in brain capillaries drives TRPC3-dependent depolarization and constriction of transitional pericytes (2025)
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Investigating Contributions of Canonical Transient Receptor Potential Channel 3 to Hippocampal Hyperexcitability and Seizure-Induced Neuronal Cell Death (2024)
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Increased Susceptibility to Pilocarpine-Induced Status Epilepticus and Reduced Latency in TRPC1/4 Double Knockout Mice (2023)
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Pharmacological Differences between Native Homomeric Transient Receptor Potential Canonical Type 4 Channels and Heteromeric Transient Receptor Potential Canonical Type 1/4 Channels in Lateral Septal Neurons (2023)
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Canonical Transient Receptor Potential Channel 3 Contributes to Cerebral Blood Flow Changes Associated with Cortical Spreading Depression in Mice (2023)
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Convulsant doses of abused synthetic cannabinoid receptor agonists AB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA and JWH-018 do not elicit electroencephalographic (EEG) seizures in male mice (2022)
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Canonical Transient Receptor Potential Channels as Novel Targets for Antiepileptic Drugs (2022)
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Leptin Activates Trpm7 Channels in the Carotid Body As a Mechanism of Obesity-Related Hypertension (2019)
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Elucidating the Involvement of Endothelial TRPC3 Channels in Neurovascular Coupling During Status Epilepticus (2018)
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TRPC Channels and Epilepsy (2017)
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TRPC 3 channels play a critical role in the theta component of pilocarpine‐induced status epilepticus in mice (2016)
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Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale (2015)
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The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity (2014)
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Critical role of canonical transient receptor potential channel 7 in initiation of seizures (2014)
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Genetic deletion of the TRPC3 channel blunts the development of angiotensin II‐induced hypertension in mice (2013)
Federal Grants 1 $372,745 total
The Role of the Endothelial NPYR1-TRPC3-ET1 Signaling Axis in Neurovascular Coupling Dysfunction
Research Interests
I have a long-standing interest in the pathophysiology of epilepsy and stroke. Initially trained as a channel biophysicist, I have also acquired experience and knowledge in molecular biology, biochemistry and pharmacology over the years. This allows me to adopt a multidisciplinary approach in my research. I have a equally long-standing interest in the functional roles of metabotropic glutamate receptor (mGluR), and this interest has led to my recent focus on transient receptor potential (TRPC) channels for the last 6 years. We have demonstrated the unique roles of various TRPC family members in seizure and excitotoxicity.
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- The role of TRPC3 channels in neurovascular coupling and peri-infarct depression UAMS College of Medicine Principal Investigator
- The role of TRPC3 channels in periinfarct depression and stroke UAMS Stroke - Foundation Principal Investigator
- The Role of Endothelial TRPC3 Channels in Neurovascular Coupling NIH Principal Investigator
- ZINC-DEPENDENT APPARENT DESENSITIZATION OF NMDA RECEPTOR NIH Principal Investigator
- Neuroscience Research Center Core Facility at UAMS NIH Co-Investigator
- MODULATION OF NMDA RECEPTORS BY TYROSINE KINASES NIH Principal Investigator
- Canonical Transient Receptor Potential Channels and Excitotoxicity NIH Principal Investigator
- METABOTROPIC GLUTAMATE RECEPTORS AND EXCITOTOXICITY NIH Principal Investigator
Collaboration Network
Top Collaborators
- Canonical Transient Receptor Channel 5 (TRPC5) and TRPC1/4 Contribute to Seizure and Excitotoxicity by Distinct Cellular Mechanisms
- Heteromeric Canonical Transient Receptor Potential 1 and 4 Channels Play a Critical Role in Epileptiform Burst Firing and Seizure-Induced Neurodegeneration
- Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale
- Critical role of canonical transient receptor potential channel 7 in initiation of seizures
- The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity
Showing 5 of 10 shared publications
- Canonical Transient Receptor Channel 5 (TRPC5) and TRPC1/4 Contribute to Seizure and Excitotoxicity by Distinct Cellular Mechanisms
- Heteromeric Canonical Transient Receptor Potential 1 and 4 Channels Play a Critical Role in Epileptiform Burst Firing and Seizure-Induced Neurodegeneration
- Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale
- Critical role of canonical transient receptor potential channel 7 in initiation of seizures
- TRPC 3 channels play a critical role in the theta component of pilocarpine‐induced status epilepticus in mice
Showing 5 of 8 shared publications
- Canonical Transient Receptor Channel 5 (TRPC5) and TRPC1/4 Contribute to Seizure and Excitotoxicity by Distinct Cellular Mechanisms
- Heteromeric Canonical Transient Receptor Potential 1 and 4 Channels Play a Critical Role in Epileptiform Burst Firing and Seizure-Induced Neurodegeneration
- Critical role of canonical transient receptor potential channel 7 in initiation of seizures
- TRPC 3 channels play a critical role in the theta component of pilocarpine‐induced status epilepticus in mice
- Increased luminal pressure in brain capillaries drives TRPC3-dependent depolarization and constriction of transitional pericytes
Showing 5 of 6 shared publications
- Canonical Transient Receptor Channel 5 (TRPC5) and TRPC1/4 Contribute to Seizure and Excitotoxicity by Distinct Cellular Mechanisms
- Critical role of canonical transient receptor potential channel 7 in initiation of seizures
- TRPC 3 channels play a critical role in the theta component of pilocarpine‐induced status epilepticus in mice
- Phenylephrine‐induced current and vasoconstriction are blunted in mesenteric arteries of TRPC3 knockout mice
- Leptin Activates Trpm7 Channels in the Carotid Body As a Mechanism of Obesity-Related Hypertension
- Phenylephrine‐induced current and vasoconstriction are blunted in mesenteric arteries of TRPC3 knockout mice
- Elucidating the Involvement of Endothelial TRPC3 Channels in Neurovascular Coupling During Status Epilepticus
- Genetic deletion of the TRPC3 channel blunts the development of angiotensin II‐induced hypertension in mice
- Canonical Transient Receptor Channel 5 (TRPC5) and TRPC1/4 Contribute to Seizure and Excitotoxicity by Distinct Cellular Mechanisms
- TRPC 3 channels play a critical role in the theta component of pilocarpine‐induced status epilepticus in mice
- Investigating Contributions of Canonical Transient Receptor Potential Channel 3 to Hippocampal Hyperexcitability and Seizure-Induced Neuronal Cell Death
- Canonical Transient Receptor Channel 5 (TRPC5) and TRPC1/4 Contribute to Seizure and Excitotoxicity by Distinct Cellular Mechanisms
- Elucidating the Involvement of Endothelial TRPC3 Channels in Neurovascular Coupling During Status Epilepticus
- Canonical Transient Receptor Channel 5 (TRPC5) and TRPC1/4 Contribute to Seizure and Excitotoxicity by Distinct Cellular Mechanisms
- Heteromeric Canonical Transient Receptor Potential 1 and 4 Channels Play a Critical Role in Epileptiform Burst Firing and Seizure-Induced Neurodegeneration
- Canonical Transient Receptor Channel 5 (TRPC5) and TRPC1/4 Contribute to Seizure and Excitotoxicity by Distinct Cellular Mechanisms
- Heteromeric Canonical Transient Receptor Potential 1 and 4 Channels Play a Critical Role in Epileptiform Burst Firing and Seizure-Induced Neurodegeneration
- Heteromeric Canonical Transient Receptor Potential 1 and 4 Channels Play a Critical Role in Epileptiform Burst Firing and Seizure-Induced Neurodegeneration
- Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale
- Heteromeric Canonical Transient Receptor Potential 1 and 4 Channels Play a Critical Role in Epileptiform Burst Firing and Seizure-Induced Neurodegeneration
- TRPC 3 channels play a critical role in the theta component of pilocarpine‐induced status epilepticus in mice
- TRPC 3 channels play a critical role in the theta component of pilocarpine‐induced status epilepticus in mice
- Elucidating the Involvement of Endothelial TRPC3 Channels in Neurovascular Coupling During Status Epilepticus
- Phenylephrine‐induced current and vasoconstriction are blunted in mesenteric arteries of TRPC3 knockout mice
- Genetic deletion of the TRPC3 channel blunts the development of angiotensin II‐induced hypertension in mice
- Molecular Determinants of Proton-Sensitive N-Methyl-d-aspartate Receptor Gating
- Molecular Determinants of Proton-Sensitive N-Methyl-d-aspartate Receptor Gating
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