A.C.W. Pike

High Impact

Researcher

University of Arkansas for Medical Sciences

faculty

42 h-index 270 pubs 11,314 cited

Research Areas

Protein Structure and Dynamics Cellular transport and secretion SARS-CoV-2 and COVID-19 Research Metabolism and Genetic Disorders Molecular Biology Techniques and Applications Health and Medical Research Impacts

Links

ORCID Lab Website Research Group

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OverviewAI-generated summary

A.C.W. Pike's research focuses on elucidating the structural basis of biological mechanisms, particularly concerning membrane transport proteins and enzymes. Recent work has investigated the structural characteristics of human urea transporters UT-A and UT-B, their inhibition, and the structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2. Pike's group has also published on the structural basis for the inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist and the transport and inhibition of the sphingosine-1-phosphate exporter SPNS2.

Further investigations include the structural basis of fatty acid elongation by ELOVL elongases and the structural basis of the mechanism and inhibition of human ceramide synthases. The lab has also explored extracellular modulation of TREK-2 activity with nanobodies to gain insight into K2P channel regulation mechanisms. Pike leads a research group at the University of Arkansas for Medical Sciences and collaborates with researchers including Tatiana Wolfe, Clint Kilts, Laura B. Dunn, and Maegan Calvert, with whom multiple shared publications exist.

Metrics

  • h-index: 42
  • Publications: 270
  • Citations: 11,314

Selected Publications

  • 511 Functional link between myelination integrity in the connectome of the cingulum bundle and information processing speed in RRMS (2025) DOI
  • 423 Innovation in MS Patient Care: Linking Cognitive Health and Myelin Integrity (2024) DOI

Collaborators

Researchers in the database who share publications

Tatiana Wolfe University of Arkansas for Medical Sciences 3 shared publications Clint Kilts University of Arkansas for Medical Sciences 2 shared publications Laura B. Dunn University of Arkansas for Medical Sciences 1 shared publication Maegan Calvert University of Arkansas for Medical Sciences 1 shared publication G. Andrew James University of Arkansas for Medical Sciences 1 shared publication Jennifer Sue Kleiner University of Arkansas for Medical Sciences 1 shared publication Jennifer L. Gess University of Arkansas for Medical Sciences 1 shared publication Jennifer L. Gess University of Arkansas for Medical Sciences 1 shared publication

Similar Researchers

Based on overlapping research topics

Miah, Md Sayem University of Arkansas for Medical Sciences
Protein Structure and Dynamics Metabolism and Genetic Disorders Molecular Biology Techniques and Applications
Strong match 4 shared topics
Patience Okoto University of Arkansas at Fayetteville
Protein Structure and Dynamics SARS-CoV-2 and COVID-19 Research Metabolism and Genetic Disorders
Good match 5 shared topics
I. V. Pokrovskaya University of Arkansas for Medical Sciences
Protein Structure and Dynamics Cellular transport and secretion Molecular Biology Techniques and Applications
Good match 4 shared topics
Farhana Taher Sumya University of Arkansas for Medical Sciences
Protein Structure and Dynamics Cellular transport and secretion Metabolism and Genetic Disorders
Good match 4 shared topics
Michael L. Smith University of Arkansas for Medical Sciences
Protein Structure and Dynamics SARS-CoV-2 and COVID-19 Research Metabolism and Genetic Disorders
Good match 5 shared topics
Gaetane Ternier University of Arkansas at Fayetteville
Protein Structure and Dynamics Metabolism and Genetic Disorders Molecular Biology Techniques and Applications
Good match 4 shared topics