A.C.W. Pike

High Impact

Researcher

UAMS

Also affiliated: Northeastern University (1992); Queensland Health (1999); Pennsylvania State University (1996); University of Miami (1994); The University of Texas at Dallas (2014); Novo Nordisk (Denmark) (1999); University of Arkansas Medical Center (2024); Discovery Centre (2023); Nuffield Foundation (2024); Nuffield Orthopaedic Centre (2024); Karolinska Institutet (2000–2005); University of Oxford (2006–2025); Karo Pharma (Sweden) (2000); Duke Medical Center (1994); Genomics England (2009–2023); Genomics (United Kingdom) (2006–2024); University of Bath (1993–1996); University of York (1997–2007); International Centre for Genetic Engineering and Biotechnology (2010)

Faculty Researcher

42 h-index 265 pubs 11,532 cited

Research Areas

Biomedical Subjects

Links

ORCID Lab Website Research Group

OverviewAI-generated summary

A.C.W. Pike's research focuses on elucidating the structural underpinnings of biological processes, particularly concerning membrane transport proteins and enzymes. Pike has published work detailing the structural basis of fatty acid elongation by ELOVL elongases, the mechanism and inhibition of human ceramide synthases, and the structure and function of the SIT1 proline transporter in complex with ACE2. Further investigations include the structural characterization of human urea transporters UT-A and UT-B and their inhibition, as well as the structural basis for the inhibition of the lysosomal two-pore channel TPC2 by small molecule antagonists.

Additional research areas include the extracellular modulation of TREK-2 activity using nanobodies to understand K2P channel regulation and the transport and inhibition mechanisms of the sphingosine-1-phosphate exporter SPNS2. Pike maintains an active research group and has collaborated with numerous researchers at the University of Arkansas for Medical Sciences, including Tatiana Wolfe and Clint Kilts.

With an h-index of 42, 265 total publications, and over 11,000 citations, Pike is recognized as a highly cited researcher. Their work contributes to a deeper understanding of molecular mechanisms in human health and disease.

Metrics

h-index: 42
Publications: 265
Citations: 11,532

Selected Publications

511 Functional link between myelination integrity in the connectome of the cingulum bundle and information processing speed in RRMS (2025)

DOI OpenAlex
423 Innovation in MS Patient Care: Linking Cognitive Health and Myelin Integrity (2024)

DOI OpenAlex