Eric R. Siegel
Biostatistician II
Also affiliated: Tufts University (1981); University of Maryland, Baltimore (2018); Greater Baltimore Medical Center (2018); St. Michael's Hospital (2012); Arkansas Children's Hospital (2026); Charleston Area Medical Center (2011); Johns Hopkins University (2018); University of Toronto (2012); New York Hall of Science (1998); University of Arkansas Medical Center (2003–2024); Johns Hopkins Medicine (2018); Princess Margaret Cancer Centre (2012); Yale University (2018); Central Arkansas Veterans Healthcare System (2001–2017); National Cancer Institute (2002); John L. McClellan Memorial Veterans Hospital (2005–2006); Hôpital d'Hautepierre (2020); Nortek (United States) (2007); University of Virginia (2023); University of Oklahoma (2003)
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Eric R. Siegel's research has focused on various aspects of cancer treatment and disease management, particularly in the context of hematological malignancies and gynecological cancers. He has investigated the thrombogenic activity of specific chemotherapy drugs, such as doxorubicin, in patients with multiple myeloma receiving thalidomide, and has explored the increased risk of deep-vein thrombosis associated with these treatments.
Siegel has also contributed to studies on the efficacy of different therapeutic regimens for uterine serous carcinomas, including randomized phase II trials comparing carboplatin-paclitaxel with carboplatin-paclitaxel-trastuzumab in cases overexpressing HER2/neu. His work includes analyses of autologous stem cell transplantation outcomes in multiple myeloma patients, with a particular focus on elderly patients and those with renal failure.
Beyond clinical oncology, Siegel's research has touched upon molecular mechanisms underlying stress resistance and longevity in model organisms, such as C. elegans mutants, by studying the modulation of lipid biosynthesis. With a career marked by extensive publication and high citation counts, he leads a research group and collaborates with several colleagues at the University of Arkansas for Medical Sciences.
Metrics
- h-index: 52
- Publications: 430
- Citations: 10,228
Positions
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Biostatistician II 2026–presentUniversity of Arkansas for Medical Sciences Biostatistics ORCID
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Biostatistics Project Manager 2017–2026University of Arkansas for Medical Sciences Biostatistics ORCID
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Research Associate 1999–2017University of Arkansas for Medical Sciences Biostatistics ORCID
Selected Publications
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Long-Term Follow-Up of Patients With Multiple Myeloma Treated on Earlier Total Therapy Protocols (2025)
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A phase 2 trial of pembrolizumab for recurrent Lynch-like versus sporadic endometrial cancers with microsatellite instability (NCT02899793): Updated survival and response analyses (2025)
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Does Patient Health Literacy Affect Patient Reported Outcome Measure Completion Method in Orthopaedic Patients? (2025)
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A customized bed based stand alone array of optically pumped magnetometers for fetal magnetocardiography measurements (2025)
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Prior exposure to belantamab mafodotin influences outcomes with idecabtagene vicleucel in patients with multiple myeloma (2025)
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N-acetylcysteine (NAC) supplementation improves dyspnea and may normalize von Willebrand plasma levels in gynecologic patients with Post-Acute-COVID-Sequela (PASC)/Long COVID (2025)
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Long-term follow-up of Total Therapy IV: a phase 3 clinical trial for standard-risk multiple myeloma (2024)
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Multi-omics reveal immune microenvironment alterations in multiple myeloma and its precursor stages (2024)
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Does Body Mass Index Affect the Success of Two-Stage Management of Periprosthetic Joint Infection? (2024)
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Younger and rural children are more likely to be hospitalized for SARS-CoV-2 infections (2024)
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Pediatric Off-Road Vehicle Injuries (2024)
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CB-839 induces reversible dormancy in lung tumor-cells (2024)
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Correlating maternal and cord-blood inflammatory markers and BDNF with human fetal brain activity recorded by magnetoencephalography: An exploratory study (2024)
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Fetal magnetocardiographic recordings with a prototype bed-based array system of optically-pumped magnetometers (2024)
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Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix (2024)
Collaboration Network
Top Collaborators
- Non-invasive detection and identification of brain activity patterns in the developing fetus
- Habituation of visual evoked responses in neonates and fetuses: A MEG study
- Neonatal and fetal response decrement of evoked responses: A MEG study
- Delayed maturation of auditory-evoked responses in growth-restricted fetuses revealed by magnetoencephalographic recordings
- Tracking the Changes in Synchrony of the Electrophysiological Activity as the Uterus Approaches Labor Using Magnetomyographic Technique
Showing 5 of 27 shared publications
- Randomized Phase II Trial of Carboplatin–Paclitaxel Compared with Carboplatin–Paclitaxel–Trastuzumab in Advanced (Stage III–IV) or Recurrent Uterine Serous Carcinomas that Overexpress Her2/Neu (NCT01367002): Updated Overall Survival Analysis
- Amplification of c‐erbB2 oncogene
- Human Papillomavirus Type 16 and 18 E7-Pulsed Dendritic Cell Vaccination of Stage IB or IIA Cervical Cancer Patients: a Phase I Escalating-Dose Trial
- Overexpression of Epithelial Cell Adhesion Molecule in Primary, Metastatic, and Recurrent/Chemotherapy-Resistant Epithelial Ovarian Cancer
- Overexpression of claudin‐3 and claudin‐4 receptors in uterine serous papillary carcinoma
Showing 5 of 24 shared publications
- Randomized Phase II Trial of Carboplatin–Paclitaxel Compared with Carboplatin–Paclitaxel–Trastuzumab in Advanced (Stage III–IV) or Recurrent Uterine Serous Carcinomas that Overexpress Her2/Neu (NCT01367002): Updated Overall Survival Analysis
- Amplification of c‐erbB2 oncogene
- Human Papillomavirus Type 16 and 18 E7-Pulsed Dendritic Cell Vaccination of Stage IB or IIA Cervical Cancer Patients: a Phase I Escalating-Dose Trial
- Overexpression of Epithelial Cell Adhesion Molecule in Primary, Metastatic, and Recurrent/Chemotherapy-Resistant Epithelial Ovarian Cancer
- Overexpression of claudin‐3 and claudin‐4 receptors in uterine serous papillary carcinoma
Showing 5 of 23 shared publications
- Preoperative Smoking and Narcotic, Benzodiazepine, and Tramadol Use are Risk Factors for Narcotic Use After Hip and Knee Arthroplasty
- Tranexamic Acid Reduces Blood Transfusions in Revision Total Hip Arthroplasty
- Social Needs of Patients Undergoing Total Joint Arthroplasty
- Streamlining Hospital Treatment of Prosthetic Joint Infection
- Patients With Hip or Knee Arthritis Underreport Narcotic Usage
Showing 5 of 16 shared publications
- Non-invasive detection and identification of brain activity patterns in the developing fetus
- Habituation of visual evoked responses in neonates and fetuses: A MEG study
- Neonatal and fetal response decrement of evoked responses: A MEG study
- Delayed maturation of auditory-evoked responses in growth-restricted fetuses revealed by magnetoencephalographic recordings
- Tracking the Changes in Synchrony of the Electrophysiological Activity as the Uterus Approaches Labor Using Magnetomyographic Technique
Showing 5 of 15 shared publications
- Non-invasive detection and identification of brain activity patterns in the developing fetus
- Habituation of visual evoked responses in neonates and fetuses: A MEG study
- Neonatal and fetal response decrement of evoked responses: A MEG study
- Delayed maturation of auditory-evoked responses in growth-restricted fetuses revealed by magnetoencephalographic recordings
- Correlation between fetal brain activity patterns and behavioral states: An exploratory fetal magnetoencephalography study
Showing 5 of 14 shared publications
- Randomized Phase II Trial of Carboplatin–Paclitaxel Compared with Carboplatin–Paclitaxel–Trastuzumab in Advanced (Stage III–IV) or Recurrent Uterine Serous Carcinomas that Overexpress Her2/Neu (NCT01367002): Updated Overall Survival Analysis
- Overexpression of Epithelial Cell Adhesion Molecule in Primary, Metastatic, and Recurrent/Chemotherapy-Resistant Epithelial Ovarian Cancer
- A phase 2 evaluation of pembrolizumab for recurrent Lynch‐like versus sporadic endometrial cancers with microsatellite instability
- A novel multiple biomarker panel for the early detection of high-grade serous ovarian carcinoma
- Eradication of chemotherapy‐resistant CD44+ human ovarian cancer stem cells in mice by intraperitoneal administration of clostridium perfringens enterotoxin
Showing 5 of 14 shared publications
- Randomized Phase II Trial of Carboplatin–Paclitaxel Compared with Carboplatin–Paclitaxel–Trastuzumab in Advanced (Stage III–IV) or Recurrent Uterine Serous Carcinomas that Overexpress Her2/Neu (NCT01367002): Updated Overall Survival Analysis
- Overexpression of Epithelial Cell Adhesion Molecule in Primary, Metastatic, and Recurrent/Chemotherapy-Resistant Epithelial Ovarian Cancer
- A phase 2 evaluation of pembrolizumab for recurrent Lynch‐like versus sporadic endometrial cancers with microsatellite instability
- A novel multiple biomarker panel for the early detection of high-grade serous ovarian carcinoma
- Eradication of chemotherapy‐resistant CD44+ human ovarian cancer stem cells in mice by intraperitoneal administration of clostridium perfringens enterotoxin
Showing 5 of 14 shared publications
- Randomized Phase II Trial of Carboplatin–Paclitaxel Compared with Carboplatin–Paclitaxel–Trastuzumab in Advanced (Stage III–IV) or Recurrent Uterine Serous Carcinomas that Overexpress Her2/Neu (NCT01367002): Updated Overall Survival Analysis
- A phase 2 evaluation of pembrolizumab for recurrent Lynch‐like versus sporadic endometrial cancers with microsatellite instability
- A novel multiple biomarker panel for the early detection of high-grade serous ovarian carcinoma
- Serum amyloid A (SAA): a novel biomarker for uterine serous papillary cancer
- A phase II evaluation of pembrolizumab in recurrent microsatellite instability-high (MSI-H) endometrial cancer patients with Lynch-like versus MLH-1 methylated characteristics (NCT02899793)
Showing 5 of 14 shared publications
- Results of autologous stem cell transplant in multiple myeloma patients with renal failure
- Autologous stem cell transplantation in elderly multiple myeloma patients over the age of 70 years
- Mobilization of CD34+ cells in elderly patients (≥ 70 years) with multiple myeloma: influence of age, prior therapy, platelet count and mobilization regimen
- Hypothyroidism in patients with multiple myeloma following treatment with thalidomide
- Improved Outcome of Allogeneic Transplantation in High-Risk Multiple Myeloma Patients After Nonmyeloablative Conditioning
Showing 5 of 14 shared publications
- In vivo liquid biopsy using Cytophone platform for photoacoustic detection of circulating tumor cells in patients with melanoma
- Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects
- Bevacizumab and Erlotinib in Previously Untreated Inoperable and Metastatic Hepatocellular Carcinoma
- Moving a Carbohydrate Mimetic Peptide into the clinic
- Dantrolene Attenuates Cardiotoxicity of Doxorubicin Without Reducing its Antitumor Efficacy in a Breast Cancer Model
Showing 5 of 13 shared publications
- Social Needs of Patients Undergoing Total Joint Arthroplasty
- Streamlining Hospital Treatment of Prosthetic Joint Infection
- Narcotic Refills and Patient Satisfaction With Pain Control After Total Joint Arthroplasty
- The Alpha-Defensin Prosthetic Joint Infection Test Has Poor Validity for Native Knee Joint Infection
- Does Patient Health Literacy Affect Patient Reported Outcome Measure Completion Method in Orthopaedic Patients?
Showing 5 of 12 shared publications
- Botulinum Toxin Infiltration for Pain Control After Mastectomy and Expander Reconstruction
- Correlation of magnetic resonance imaging and pathologic size of infiltrating lobular carcinoma of the breast
- The receptor expression pattern in ductal carcinoma in situ predicts recurrence
- Prevention of nausea and vomiting following breast surgery
- Dantrolene Attenuates Cardiotoxicity of Doxorubicin Without Reducing its Antitumor Efficacy in a Breast Cancer Model
Showing 5 of 11 shared publications
- Results of autologous stem cell transplant in multiple myeloma patients with renal failure
- Autologous stem cell transplantation in elderly multiple myeloma patients over the age of 70 years
- Mobilization of CD34+ cells in elderly patients (≥ 70 years) with multiple myeloma: influence of age, prior therapy, platelet count and mobilization regimen
- Hypothyroidism in patients with multiple myeloma following treatment with thalidomide
- Improved Outcome of Allogeneic Transplantation in High-Risk Multiple Myeloma Patients After Nonmyeloablative Conditioning
Showing 5 of 11 shared publications
- Recording and quantifying fetal magnetocardiography signals using a flexible array of optically-pumped magnetometers
- Characterizing pelvic floor muscles activities using magnetomyography
- Studying the Effect of Maternal Pregestational Diabetes on Fetal Neurodevelopment Using Magnetoencephalography
- Selection of Reference Channels Based on Mutual Information for Frequency-Dependent Subtraction Method Applied to Fetal Biomagnetic Signals
- Fetal magnetocardiographic recordings with a prototype bed-based array system of optically-pumped magnetometers
Showing 5 of 11 shared publications
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