Chia Y. Lee
Professor
Also affiliated: University of Nebraska–Lincoln (2010); Tufts University (2010); University of Kansas Medical Center (1991–2005); New York University (2015); University of Nebraska Medical Center (2010)
Faculty Researcher
Microbiology & Immunology, College of Medicine
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Chia Y. Lee's research focuses on the molecular mechanisms underlying *Staphylococcus aureus* infections, particularly the regulation of virulence factors and the formation of bacterial biofilms. Lee has received federal funding from the National Institute of Allergy and Infectious Diseases (NIAID) for two grant awards totaling $457,500. One award supports research into the characterization of a novel *S. aureus* biofilm polysaccharide, while the other investigates the modulation of the Agr system by the ClpC chaperone in *S. aureus*.
Published work includes studies on the characterization of an *N*-acetylgalactosamine-containing surface polysaccharide in *S. aureus*, the development of a rat model for orthopedic implant-associated infections to identify staphylococcal biofilm proteins, and the regulation of the staphylococcal capsule by SarZ, which was found to be SigA-dependent. Lee's scholarship metrics include an h-index of 37, with 63 total publications and over 4,855 citations. Key collaborators at the University of Arkansas for Medical Sciences include Mei G. Lei, Ravi Kr. Gupta, Matthew A. Jorgenson, and Emily J. Robbs.
Metrics
- h-index: 37
- Publications: 63
- Citations: 4,893
Selected Publications
-
Characterization of Ssc, an <i>N</i> -acetylgalactosamine-containing <i>Staphylococcus aureus</i> surface polysaccharide (2024)
-
Regulation of Staphylococcal Capsule by SarZ is SigA-Dependent (2022)
-
A Rat Model of Orthopedic Implant-Associated Infection for Identification of Staphylococcal Biofilm Proteins (2021)
-
MgrA Activates Staphylococcal Capsule via SigA-Dependent Promoter (2020)
-
MgrA Negatively Impacts Staphylococcus aureus Invasion by Regulating Capsule and FnbA (2019)
-
Contribution of <i>hla</i> Regulation by SaeR to Staphylococcus aureus USA300 Pathogenesis (2019)
-
Repression of Capsule Production by XdrA and CodY in Staphylococcus aureus (2018)
-
Proteomics of Staphylococcus aureus biofilm matrix in a rat model of orthopedic implant-associated infection (2017)
-
Minimum Information about a Biosynthetic Gene cluster (2015)
-
RNAIII of the <i>Staphylococcus aureus agr</i> system activates global regulator MgrA by stabilizing mRNA (2015)
-
Comparative impact of diverse regulatory loci on <i>Staphylococcus aureus</i> biofilm formation (2015)
-
SaeRS-Dependent Inhibition of Biofilm Formation in Staphylococcus aureus Newman (2015)
-
Recombination-mediated remodelling of host–pathogen interactions during Staphylococcus aureus niche adaptation (2015)
-
RbsR Activates Capsule but Represses the <i>rbsUDK</i> Operon in Staphylococcus aureus (2015)
-
Trapping and Identification of Cellular Substrates of the Staphylococcus aureus ClpC Chaperone (2014)
Federal Grants 2 $457,500 total
Characterization of a novel S. aureus biofilm polysaccharide
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Regulation of biofilm formation in clinical isolates of Staphylococcus aureus NIH Co-Investigator
- Proteomic analysis of S aureus biofilm in vivo NIH Principal Investigator
- STAPHYLOCOCCAL CAPSULE AND VIRULENCE NIH Principal Investigator
- Global regulation by mgr in S. aureus NIH Principal Investigator
- Virulence gene regulation in Staphylococcus aureus NIH Select
- Capsule regulatory network in S. aureus pathogenesis NIH Principal Investigator
- Regulation of Staphylococcus aureus biofilm by Rbf NIH Principal Investigator
Collaboration Network
Top Collaborators
- Characterization of Ssc, an <i>N</i> -acetylgalactosamine-containing <i>Staphylococcus aureus</i> surface polysaccharide
- A Rat Model of Orthopedic Implant-Associated Infection for Identification of Staphylococcal Biofilm Proteins
- Regulation of Staphylococcal Capsule by SarZ is SigA-Dependent
- A Rat Model of Orthopedic Implant-Associated Infection for Identification of Staphylococcal Biofilm Proteins
- Characterization of Ssc, an <i>N</i> -acetylgalactosamine-containing <i>Staphylococcus aureus</i> surface polysaccharide
- Characterization of Ssc, an <i>N</i> -acetylgalactosamine-containing <i>Staphylococcus aureus</i> surface polysaccharide
- Characterization of Ssc, an <i>N</i> -acetylgalactosamine-containing <i>Staphylococcus aureus</i> surface polysaccharide
- Characterization of Ssc, an <i>N</i> -acetylgalactosamine-containing <i>Staphylococcus aureus</i> surface polysaccharide
- Characterization of Ssc, an <i>N</i> -acetylgalactosamine-containing <i>Staphylococcus aureus</i> surface polysaccharide
- Characterization of Ssc, an <i>N</i> -acetylgalactosamine-containing <i>Staphylococcus aureus</i> surface polysaccharide
Similar Researchers
Based on overlapping research topics